| TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model. | TLR5-deficiency controls dendritic cell subset development in an autoimmune diabetes-susceptible model.
Pearson JA, Hu Y, Peng J, Wong FS, Wen L., Free PMC Article | 03/18/2024 |
| Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model. | Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model.
Alajoleen RM, Oakland DN, Estaleen R, Shakeri A, Lu R, Appiah M, Sun S, Neumann J, Kawauchi S, Cecere TE, McMillan RP, Reilly CM, Luo XM., Free PMC Article | 02/20/2024 |
| Mucosal TLR5 activation controls healthspan and longevity. | Mucosal TLR5 activation controls healthspan and longevity.
Lim JS, Jeon EJ, Go HS, Kim HJ, Kim KY, Nguyen TQT, Lee DY, Kim KS, Pietrocola F, Hong SH, Lee SE, Kim KS, Park TS, Choi DH, Jeong YJ, Park JH, Kim HS, Min JJ, Kim YS, Park JT, Cho JH, Lee GW, Lee JH, Choy HE, Park SC, Lee CH, Rhee JH, Serrano M, Cho KA., Free PMC Article | 01/9/2024 |
| Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food. | Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food.
Kemter AM, Patry RT, Arnold J, Hesser LA, Campbell E, Ionescu E, Mimee M, Wang S, Nagler CR., Free PMC Article | 11/8/2023 |
| Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome. | Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
Kamada H, Emura K, Yamamoto R, Kawahara K, Uto S, Minami T, Ito S, Matsumoto KI, Okuda-Ashitaka E., Free PMC Article | 10/30/2023 |
| Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation. | Toll-like receptor 5 tunes hepatic and pancreatic stellate cells activation.
Di Fazio P, Mielke S, Böhm IT, Buchholz M, Matrood S, Schuppan D, Wissniowski T., Free PMC Article | 07/13/2023 |
| Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice. | Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice.
Golonka RM, Yeoh BS, Saha P, Gohara A, Tummala R, Stepkowski S, Tiwari AK, Joe B, Gonzalez FJ, Gewirtz AT, Vijay-Kumar M., Free PMC Article | 05/31/2023 |
| Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation. | Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation.
Mallaret G, Lashermes A, Meleine M, Boudieu L, Barbier J, Aissouni Y, Gelot A, Chassaing B, Gewirtz AT, Ardid D, Carvalho FA., Free PMC Article | 10/8/2022 |
| Toll-Like Receptor 5 Promotes the Neurogenesis From Embryonic Stem Cells and Adult Hippocampal Neural Stem Cells in Mice. | Toll-Like Receptor 5 Promotes the Neurogenesis From Embryonic Stem Cells and Adult Hippocampal Neural Stem Cells in Mice.
Seong KJ, Choi S, Lee HG, Rhee JH, Lee JH, Koh JT, Kim SH, Choi WS, Jung JY, Kim WJ. | 04/9/2022 |
| Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock. | Role of TLR5 in the Translocation and Dissemination of Commensal Bacteria in the Intestine after Traumatic Hemorrhagic Shock.
Zhang Y, Zhang J, Xu T, Zhang C, Yu WQ, Wei T, Zhang B, Chen Q, Qiu JY, Li HJ, Liang TB., Free PMC Article | 03/12/2022 |
| Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice. | Bacteroides uniformis CECT 7771 alleviates inflammation within the gut-adipose tissue axis involving TLR5 signaling in obese mice.
Fabersani E, Portune K, Campillo I, López-Almela I, la Paz SM, Romaní-Pérez M, Benítez-Páez A, Sanz Y., Free PMC Article | 12/4/2021 |
| TLR5 is expressed in Paneth cells and this sensitizes them to TNF-mediated cell death in the context of XIAP-deficiency. TLR5 is also expressed on type II dendritic cells within the small intestine, and this also sensitizes them to cell death. | XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
Wahida A, Müller M, Hiergeist A, Popper B, Steiger K, Branca C, Tschurtschenthaler M, Engleitner T, Donakonda S, De Coninck J, Öllinger R, Pfautsch MK, Müller N, Silva M, Usluer S, Thiele Orberg E, Böttcher JP, Pfarr N, Anton M, Slotta-Huspenina JB, Nerlich AG, Madl T, Basic M, Bleich A, Berx G, Ruland J, Knolle PA, Rad R, Adolph TE, Vandenabeele P, Kanegane H, Gessner A, Jost PJ, Yabal M. | 11/15/2021 |
| TLR5 Activation Exacerbates Airway Inflammation in Asthma. | TLR5 Activation Exacerbates Airway Inflammation in Asthma.
Whitehead GS, Hussain S, Fannin R, Trempus CS, Innes CL, Schurman SH, Cook DN, Garantziotis S., Free PMC Article | 07/24/2021 |
| Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety. | Toll-like receptor 5 knock-out mice exhibit a specific low level of anxiety.
Hamieh AM, Mallaret G, Meleine M, Lashermes A, Roumeau S, Boudieu L, Barbier J, Aissouni Y, Ardid D, Gewirtz AT, Carvalho FA, Marchand F. | 06/12/2021 |
| Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice. | Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice.
Ma ZG, Kong CY, Wu HM, Song P, Zhang X, Yuan YP, Deng W, Tang QZ., Free PMC Article | 06/5/2021 |
| Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury. | Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury.
Ifuku M, Hinkelmann L, Kuhrt LD, Efe IE, Kumbol V, Buonfiglioli A, Krüger C, Jordan P, Fulde M, Noda M, Kettenmann H, Lehnardt S., Free PMC Article | 06/5/2021 |
| TLR5 activation in hepatocytes alleviates the functional suppression of intrahepatic CD8(+) T cells. | TLR5 activation in hepatocytes alleviates the functional suppression of intrahepatic CD8(+) T cells.
Yan H, Zhong M, Yang J, Guo J, Yu J, Yang Y, Ma Z, Zhao B, Zhang Y, Wang J, Wu C, Dittmer U, Yang D, Lu M, Zhang E, Yan H., Free PMC Article | 05/29/2021 |
| Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver. | Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver.
Yiu JHC, Chan KS, Cheung J, Li J, Liu Y, Wang Y, Fung WWL, Cai J, Cheung SWM, Dorweiler B, Wan EYF, Tso P, Xu A, Woo CW., Free PMC Article | 05/22/2021 |
| TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury. | TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.
Hussain S, Johnson CG, Sciurba J, Meng X, Stober VP, Liu C, Cyphert-Daly JM, Bulek K, Qian W, Solis A, Sakamachi Y, Trempus CS, Aloor JJ, Gowdy KM, Foster WM, Hollingsworth JW, Tighe RM, Li X, Fessler MB, Garantziotis S., Free PMC Article | 04/24/2021 |
| TLR5 is a new reporter for triple-negative breast cancer indicated by radioimmunoimaging and fluorescent staining. | TLR5 is a new reporter for triple-negative breast cancer indicated by radioimmunoimaging and fluorescent staining.
Shi D, Liu W, Zhao S, Zhang C, Liang T, Hou G., Free PMC Article | 09/26/2020 |
| TLR5: A prognostic and monitoring indicator for triple-negative breast cancer. | TLR5: A prognostic and monitoring indicator for triple-negative breast cancer.
Shi D, Zhao S, Jiang W, Zhang C, Liang T, Hou G., Free PMC Article | 09/12/2020 |
| Fermentable fiber-induced cholestasis is characterized with modest macro- and micronutrient deficiencies that may further contribute to hepatic biliary disease. | Fermentable fibers induce rapid macro- and micronutrient depletion in Toll-like receptor 5-deficient mice.
Golonka RM, San Yeoh B, Li Y, Saha P, Abokor AA, Cheng X, Xiao X, Chandrashekar DS, Varambally S, Gonzalez DJ, Ross AC, Vijay-Kumar M., Free PMC Article | 08/1/2020 |
| Activation of the TLR5-Nox4 cascade plays an important role in the formation of neointimal atherosclerotic plaques. | The flagellin-TLR5-Nox4 axis promotes the migration of smooth muscle cells in atherosclerosis.
Kim J, Yoo JY, Suh JM, Park S, Kang D, Jo H, Bae YS., Free PMC Article | 06/27/2020 |
| The authors conclude that detection of Escherichia coli FliC through TLR5 triggers rapid IL-10 synthesis in the bladder. | Rapid Bladder Interleukin-10 Synthesis in Response to Uropathogenic Escherichia coli Is Part of a Defense Strategy Triggered by the Major Bacterial Flagellar Filament FliC and Contingent on TLR5.
Acharya D, Sullivan MJ, Duell BL, Goh KGK, Katupitiya L, Gosling D, Chamoun MN, Kakkanat A, Chattopadhyay D, Crowley M, Crossman DK, Schembri MA, Ulett GC., Free PMC Article | 06/6/2020 |
| The findings demonstrate a novel role of TLR5 and provide new insights into the mechanism underlying inflammation and tissue damage after intestinal I/R injury. | Role of TLR5 in inflammation and tissue damage after intestinal ischemia-reperfusion injury.
Ito H, Sadatomo A, Inoue Y, Yamada N, Aizawa E, Hishida E, Kamata R, Karasawa T, Kimura H, Watanabe S, Komada T, Horie H, Kitayama J, Sata N, Takahashi M. | 05/30/2020 |