| CHOP upregulation and dysregulation of the mature form of the SNAT2 amino acid transporter in the placentas from small for gestational age newborns. | CHOP upregulation and dysregulation of the mature form of the SNAT2 amino acid transporter in the placentas from small for gestational age newborns.
Barroso E, Díaz M, Reguera AC, Peyman M, Balsinde J, Jurado-Aguilar J, Zhang M, Rostami A, Palomer X, Ibáñez L, Vázquez-Carrera M., Free PMC Article | 11/29/2023 |
| Hsa_circRNA_001859 regulates pancreatic cancer progression and epithelial-mesenchymal transition through the miR-21-5p/SLC38A2 pathway. | Hsa_circRNA_001859 regulates pancreatic cancer progression and epithelial-mesenchymal transition through the miR-21-5p/SLC38A2 pathway.
Li L, Wang N, Wang J, Li J., Free PMC Article | 05/17/2023 |
| Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma. | Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma.
Wan Y, Chen M, Li X, Han X, Zhong L, Xiao F, Liu J, Xiang J, Jiang J, Chen X, Liu J, Li H, Li B, Huang H, Hou J. | 05/1/2023 |
| Comprehensive analysis of the biological function and immune infiltration of SLC38A2 in gastric cancer. | Comprehensive analysis of the biological function and immune infiltration of SLC38A2 in gastric cancer.
Zhu L, Wang Z, Han W, Xu A., Free PMC Article | 03/22/2023 |
| SNAT2/SLC38A2 Confers the Stemness of Gastric Cancer Cells via Regulating Glutamine Level. | SNAT2/SLC38A2 Confers the Stemness of Gastric Cancer Cells via Regulating Glutamine Level.
Nie K, Cai M. | 07/2/2022 |
| LAT1 and SNAT2 Protein Expression and Membrane Localization of LAT1 Are Not Acutely Altered by Dietary Amino Acids or Resistance Exercise Nor Positively Associated with Leucine or Phenylalanine Incorporation in Human Skeletal Muscle. | LAT1 and SNAT2 Protein Expression and Membrane Localization of LAT1 Are Not Acutely Altered by Dietary Amino Acids or Resistance Exercise Nor Positively Associated with Leucine or Phenylalanine Incorporation in Human Skeletal Muscle.
Mazzulla M, Hodson N, Lees M, Scaife PJ, Smith K, Atherton PJ, Kumbhare D, Moore DR., Free PMC Article | 12/18/2021 |
| SLC38A2 Overexpression Induces a Cancer-like Metabolic Profile and Cooperates with SLC1A5 in Pan-cancer Prognosis. | SLC38A2 Overexpression Induces a Cancer-like Metabolic Profile and Cooperates with SLC1A5 in Pan-cancer Prognosis.
Huang MS, Chang JH, Lin WC, Cheng YH, Li FA, Suen CS, Hwang MJ, Chang CK, Mou KY. | 05/22/2021 |
| Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer. | Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer.
Morotti M, Zois CE, El-Ansari R, Craze ML, Rakha EA, Fan SJ, Valli A, Haider S, Goberdhan DCI, Green AR, Harris AL., Free PMC Article | 04/17/2021 |
| Functional Consequences of Low Activity of Transport System A for Neutral Amino Acids in Human Bone Marrow Mesenchymal Stem Cells. | Functional Consequences of Low Activity of Transport System A for Neutral Amino Acids in Human Bone Marrow Mesenchymal Stem Cells.
Chiu M, Taurino G, Bianchi MG, Dander E, Fallati A, Giuliani N, D'Amico G, Bussolati O., Free PMC Article | 12/5/2020 |
| We describe how Slc38a2 senses amino acid availability and passes this onto intracellular signaling pathways and how it regulates protein synthesis, cellular proliferation and apoptosis through the mechanistic (mammalian) target of rapamycin (mTOR) and general control nonderepressible 2 (GCN2) pathways--{REVIEW} | Multifaceted regulation of the system A transporter Slc38a2 suggests nanoscale regulation of amino acid metabolism and cellular signaling.
Menchini RJ, Chaudhry FA. | 07/18/2020 |
| findings show a switch in the regulation of SNAT2 between ERalpha and HIF-1alpha, leading to endocrine resistance in hypoxia | Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.
Morotti M, Bridges E, Valli A, Choudhry H, Sheldon H, Wigfield S, Gray N, Zois CE, Grimm F, Jones D, Teoh EJ, Cheng WC, Lord S, Anastasiou D, Haider S, McIntyre A, Goberdhan DCI, Buffa F, Harris AL., Free PMC Article | 04/11/2020 |
| nutrient ingestion during repeated 30-s bouts of sprint exercise induces expression of the amino acid transporter SNAT2 and stimulates Akt/mTOR signaling and most likely the rate of muscle protein synthesis | Influence of nutrient ingestion on amino acid transporters and protein synthesis in human skeletal muscle after sprint exercise.
Rundqvist HC, Esbjörnsson M, Rooyackers O, Österlund T, Moberg M, Apro W, Blomstrand E, Jansson E. | 06/23/2019 |
| there is a disulfide bond between Cys245 and Cys279 in SNAT2 which has no effect on cell surface trafficking, as well as transporter function | Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification.
Chen C, Wang J, Cai R, Yuan Y, Guo Z, Grewer C, Zhang Z., Free PMC Article | 07/22/2017 |
| In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport. | Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.
Bröer A, Rahimi F, Bröer S., Free PMC Article | 11/19/2016 |
| Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2. | Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2.
Rosario FJ, Dimasuay KG, Kanai Y, Powell TL, Jansson T., Free PMC Article | 07/2/2016 |
| Decreased placental mTOR activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR. | Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR.
Chen YY, Rosario FJ, Shehab MA, Powell TL, Gupta MB, Jansson T., Free PMC Article | 12/26/2015 |
| GADD34 promotes cell survival and adaptation to increased extracellular osmolarity by increasing the uptake of small neutral amino acids via the amino acid transporter SNAT2. | Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity.
Krokowski D, Jobava R, Guan BJ, Farabaugh K, Wu J, Majumder M, Bianchi MG, Snider MD, Bussolati O, Hatzoglou M., Free PMC Article | 10/17/2015 |
| Increased availability of unsaturated fatty acids can compromise the stress-induced induction/adaptation in SNAT2 expression. | Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability.
Nardi F, Hoffmann TM, Stretton C, Cwiklinski E, Taylor PM, Hundal HS., Free PMC Article | 06/6/2015 |
| SLC38A1 and SLC38A2 transcript levels are altered in placental malaria with intervillositis. | Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport.
Boeuf P, Aitken EH, Chandrasiri U, Chua CL, McInerney B, McQuade L, Duffy M, Molyneux M, Brown G, Glazier J, Rogerson SJ., Free PMC Article | 09/6/2014 |
| SNAT2 mRNA levels were significantly decreased in intrauterine growth-restricted placentas with reduced umbilical blood flows. | SNAT2 expression and regulation in human growth-restricted placentas.
Mandò C, Tabano S, Pileri P, Colapietro P, Marino MA, Avagliano L, Doi P, Bulfamante G, Miozzo M, Cetin I. | 03/1/2014 |
| Placental mRNA expression of system A transporter isoforms SLC38A1 and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants. | Effect of maternal age and growth on placental nutrient transport: potential mechanisms for teenagers' predisposition to small-for-gestational-age birth?
Hayward CE, Greenwood SL, Sibley CP, Baker PN, Challis JR, Jones RL., Free PMC Article | 02/18/2012 |
| findings show methylation status of rRNA differentially influenced the mechanism of 80S complex formation on IRES elements from SNAT2)versus the hepatitis C virus mRNA | Requirement of rRNA methylation for 80S ribosome assembly on a cohort of cellular internal ribosome entry sites.
Basu A, Das P, Chaudhuri S, Bevilacqua E, Andrews J, Barik S, Hatzoglou M, Komar AA, Mazumder B., Free PMC Article | 12/24/2011 |
| Proteomic analysis of TAP-tag purified SNAT2 fusion proteins identified two novel SNAT2-interacting proteins that may potentially function in conjunction with SNAT2 transceptor to regulate signalling pathways influencing protein turnover and cell growth | SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?
Pinilla J, Aledo JC, Cwiklinski E, Hyde R, Taylor PM, Hundal HS. | 10/15/2011 |
| Lower placental system A activity in women who reported strenuous exercise and had a lower arm muscle area may reflect an adaptation in placental function which protects maternal resources in those with lower nutrient reserves. | Maternal muscle mass may influence system A activity in human placenta.
Lewis RM, Greenwood SL, Cleal JK, Crozier SR, Verrall L, Inskip HM, Cameron IT, Cooper C, Sibley CP, Hanson MA, Godfrey KM. | 08/9/2010 |
| we have identified a novel regulatory pathway involving increased gene expression of the SNAT2 isoform mediated by a STAT-dependent pathway, which links IL-6 to increased activity of amino acid transporter system A | IL-6 stimulates system A amino acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2.
Jones HN, Jansson T, Powell TL. | 01/21/2010 |