| Structural and biochemical characterization of active sites mutant in human inorganic pyrophosphatase. | Structural and biochemical characterization of active sites mutant in human inorganic pyrophosphatase.
Zheng S, Zheng C, Chen S, Guo J, Huang L, Huang Z, Xu S, Wu Y, Li S, Lin J, You Y, Hu F. | 04/10/2024 |
| PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis. | PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis.
Kirkbride JA, Nilsson GY, Kim JI, Takeya K, Tanaka Y, Tokumitsu H, Suizu F, Eto M., Free PMC Article | 01/3/2024 |
| Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer. | Inorganic pyrophosphatase 1 activates the phosphatidylinositol 3-kinase/Akt signaling to promote tumorigenicity and stemness properties in colorectal cancer.
Niu T, Zhu J, Dong L, Yuan P, Zhang L, Liu D. | 06/15/2023 |
| Crystallographic and modeling study of the human inorganic pyrophosphatase 1: A potential anti-cancer drug target. | Crystallographic and modeling study of the human inorganic pyrophosphatase 1: A potential anti-cancer drug target.
Niu H, Zhu J, Qu Q, Zhou X, Huang X, Du Z. | 01/8/2022 |
| Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity. | Basolateral protein Scribble binds phosphatase PP1 to establish a signaling network maintaining apicobasal polarity.
Troyanovsky RB, Indra I, Kato R, Mitchell BJ, Troyanovsky SM., Free PMC Article | 12/18/2021 |
| PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression. | PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression.
Saidy B, Kotecha S, Butler A, Rakha EA, Ellis IO, Green AR, Martin SG, Storr SJ., Free PMC Article | 10/2/2021 |
| The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture. | The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture.
Bresch AM, Yerich N, Wang R, Sperry AO., Free PMC Article | 07/31/2021 |
| Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells. | Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.
Verdugo-Sivianes EM, Rojas AM, Muñoz-Galván S, Otero-Albiol D, Carnero A., Free PMC Article | 07/24/2021 |
| PP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20. | PP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20.
Bancroft J, Holder J, Geraghty Z, Alfonso-Pérez T, Murphy D, Barr FA, Gruneberg U., Free PMC Article | 06/12/2021 |
| PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore. | PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore.
Smith RJ, Cordeiro MH, Davey NE, Vallardi G, Ciliberto A, Gross F, Saurin AT., Free PMC Article | 09/5/2020 |
| CDK1-counteracting phosphatases PP1 and PP2A-B55, together with Aurora and Polo kinases, contribute to the temporal regulation and order of events in the different stages of mitotic exit from anaphase to cytokinesis. (Review) | Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A.
Holder J, Poser E, Barr FA. | 06/20/2020 |
| PP1-NIPP1 expression resulted in the build up of RNA-DNA hybrids (R-loops), enhanced chromatin compaction and a diminished repair of DNA double-strand breaks. | Overexpression of PP1-NIPP1 limits the capacity of cells to repair DNA double-strand breaks.
Winkler C, Rouget R, Wu D, Beullens M, Van Eynde A, Bollen M. | 11/23/2019 |
| Study identified phosphorylation of RV[S/T]F motifs in known and previously unidentified PP1 regulatory proteins as a cell cycle-dependent event and shows that Aurora B was the primary kinase responsible for this phosphorylation event during mitosis. | Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.
Nasa I, Rusin SF, Kettenbach AN, Moorhead GB., Free PMC Article | 10/19/2019 |
| The p37 controls cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently of Galphai, the kinase Aurora A, and the phosphatase PP2A. | p37/UBXN2B regulates spindle orientation by limiting cortical NuMA recruitment via PP1/Repo-Man.
Lee BH, Schwager F, Meraldi P, Gotta M., Free PMC Article | 12/22/2018 |
| Proteomic profiling identifies the inorganic pyrophosphatase (PPA1) protein as a potential biomarker of metastasis in laryngeal squamous cell carcinoma. | Proteomic profiling identifies the inorganic pyrophosphatase (PPA1) protein as a potential biomarker of metastasis in laryngeal squamous cell carcinoma.
Bodnar M, Luczak M, Bednarek K, Szylberg L, Marszalek A, Grenman R, Szyfter K, Jarmuz-Szymczak M, Giefing M., Free PMC Article | 12/9/2017 |
| Results show that PPA1 expression is significantly higher in many tumors, especially those of lung and ovarian origin, which suggests that PPA1 plays an important role in carcinogenesis and in the development of some tumors. | Clinical significance and functional validation of PPA1 in various tumors.
Luo D, Wang G, Shen W, Zhao S, Zhou W, Wan L, Yuan L, Yang S, Xiang R., Free PMC Article | 11/18/2017 |
| PPA1 serves as a potential prognostic biomarker for patients with Ovarian serous carcinoma. | Expression of Inorganic Pyrophosphatase (PPA1) Correlates with Poor Prognosis of Epithelial Ovarian Cancer.
Li H, Xiao N, Li Z, Wang Q. | 04/8/2017 |
| enhanced NEK2 expression in hepatocellular carcinoma (HCC) promotes HCC progression and drug resistance by promoting PP1/Akt and Wnt pathway activation, which may represent a new therapeutic target for HCC. | Increased NEK2 in hepatocellular carcinoma promotes cancer progression and drug resistance by promoting PP1/Akt and Wnt activation.
Wen S, Liu Y, Yang M, Yang K, Huang J, Feng D. | 03/11/2017 |
| Thus, the Ska complex, specifically the Ska1 C-terminal domain, recruits PP1 to kinetochores to oppose spindle checkpoint signaling kinases and promote anaphase onset. | The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores.
Sivakumar S, Janczyk PŁ, Qu Q, Brautigam CA, Stukenberg PT, Yu H, Gorbsky GJ., Free PMC Article | 01/14/2017 |
| PPA1 may serve as a potential biomarker of poor prognosis in patients with gastric cancer | Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer.
Yang Y, Cai J, Yin J, Wang D, Bai Z, Zhang J, Wang K, Yu G, Zhang Z., Free PMC Article | 10/8/2016 |
| PP-1 and Akt have roles in AR-v7 protein expression and activities when AR is functionally blocked | AR-v7 protein expression is regulated by protein kinase and phosphatase.
Li Y, Xie N, Gleave ME, Rennie PS, Dong X., Free PMC Article | 08/27/2016 |
| The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a, which is mediated by continual activation of PKR and degradation of PP1. | Regulation of de novo translation of host cells by manipulation of PERK/PKR and GADD34-PP1 activity during Newcastle disease virus infection.
Liao Y, Gu F, Mao X, Niu Q, Wang H, Sun Y, Song C, Qiu X, Tan L, Ding C. | 08/27/2016 |
| Measles virus binding to DC-SIGN leads to inhibition of PP1 phosphatase activity and hence inhibition of RIG-I and Mda5 dephosphorylation. | Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.
Mesman AW, Zijlstra-Willems EM, Kaptein TM, de Swart RL, Davis ME, Ludlow M, Duprex WP, Gack MU, Gringhuis SI, Geijtenbeek TB., Free PMC Article | 08/29/2015 |
| The human PP1 interaction with the measles V protein is mediated by a conserved PP1-binding motif in the C-terminal region of the V protein. | Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.
Davis ME, Wang MK, Rennick LJ, Full F, Gableske S, Mesman AW, Gringhuis SI, Geijtenbeek TB, Duprex WP, Gack MU., Free PMC Article | 08/29/2015 |
| Results identify PP1 as a novel regulator of Cl(-)-HCO3(-) anion exchangers activity which, in concert with CFTR, coordinates events at both apical and basolateral membranes, crucial for efficient HCO3(-) secretion from Calu-3 cells. | Protein phosphatase 1 coordinates CFTR-dependent airway epithelial HCO3- secretion by reciprocal regulation of apical and basolateral membrane Cl(-)-HCO3- exchangers.
Garnett JP, Hickman E, Tunkamnerdthai O, Cuthbert AW, Gray MA., Free PMC Article | 07/25/2015 |