| Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype. | Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype.
Sarró E, Durán M, Rico A, Bou-Teen D, Fernández-Majada V, Croatt AJ, Nath KA, Salcedo MT, Gundelach JH, Batlle D, Bram RJ, Meseguer A., Free PMC Article | 08/14/2021 |
| Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication. | Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication.
Ma-Lauer Y, Zheng Y, Malešević M, von Brunn B, Fischer G, von Brunn A., Free PMC Article | 10/3/2020 |
| findings suggested that CypB silencing may suppress the proliferation, invasion, migration and angiogenesis of A549 cells via inhibiting STAT3 pathway. | Cyclophilin B promotes cell proliferation, migration, invasion and angiogenesis via regulating the STAT3 pathway in non-small cell lung cancer.
Teng MR, Huang JA, Zhu ZT, Li H, Shen JF, Chen Q. | 01/11/2020 |
| Results provide novel structural information on how PPIB interacts with other components of the P3H1 complex and indicate that the integrity of P3H1 complex is required for proper collagen formation. | Characterization of PPIB interaction in the P3H1 ternary complex and implications for its pathological mutations.
Wu J, Zhang W, Xia L, Feng L, Shu Z, Zhang J, Ye W, Zeng N, Zhou A., Free PMC Article | 10/19/2019 |
| A graphene-based nanocarrier modified with death receptor 4 (DR4) antibody and AKT siRNA has been developed, which can synergistically strengthen death receptor-mediated apoptosis and enhance the cancer therapeutic effect in vivo. | A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis.
Pan W , Gong S , Li Y , Zhang H , Li N , Tang B . | 12/22/2018 |
| Data show that Cyclophilin B is present on the erythrocytes and binds strongly to merozoites. | Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum.
Prakash P, Zeeshan M, Saini E, Muneer A, Khurana S, Kumar Chourasia B, Deshmukh A, Kaur I, Dabral S, Singh N, Anam Z, Chaurasiya A, Kaushik S, Dahiya P, Kalamuddin M, Kumar Thakur J, Mohmmed A, Ranganathan A, Malhotra P., Free PMC Article | 09/29/2018 |
| cyclophilin B (CYPB) functions in protecting cells against aldosterone-induced oxidative stress, endoplasmic reticulum stress (ERS) and tubular cell injury via its peptidyl-prolyl cis-trans isomerase (PPIase) activity. | Overexpressed cyclophilin B suppresses aldosterone-induced proximal tubular cell injury both in vitro and in vivo.
Wang B, Lin L, Wang H, Guo H, Gu Y, Ding W., Free PMC Article | 02/24/2018 |
| PPIB mutations and their associated phenotypes | Two novel mutations in the PPIB gene cause a rare pedigree of osteogenesis imperfecta type IX.
Jiang Y, Pan J, Guo D, Zhang W, Xie J, Fang Z, Guo C, Fang Q, Jiang W, Guo Y. | 01/6/2018 |
| observed changes in activity of six rER-resident PPIases, cyclophilin B (encoded by the PPIB gene), FKBP13 (FKBP2), FKBP19 (FKBP11), FKBP22 (FKBP14), FKBP23 (FKBP7), and FKBP65 (FKBP10), due to posttranslational modifications of proline residues in the substrate. | Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline.
Ishikawa Y, Mizuno K, Bächinger HP., Free PMC Article | 06/10/2017 |
| The data suggest that overexpressed CypB protects neuronal cells from MPP+-induced dopaminergic neuronal cell death | Cyclophilin B protects SH-SY5Y human neuroblastoma cells against MPP(+)-induced neurotoxicity via JNK pathway.
Oh Y, Jeong K, Kim K, Lee YS, Jeong S, Kim SS, Yoon KS, Ha J, Kang I, Choe W. | 06/3/2017 |
| This study enhances our knowledge about the mutational pattern of the LEPRE1, CRTAP, and PPIB genes. LEPRE1 should be the first gene analyzed in mutation detection studies in patients with recessive OI. | Mutational characterization of the P3H1/CRTAP/CypB complex in recessive osteogenesis imperfecta.
Barbirato C, Trancozo M, Almeida MG, Almeida LS, Santos TO, Duarte JC, Rebouças MR, Sipolatti V, Nunes VR, Paula F. | 09/17/2016 |
| Over-expression of CypB enhances HIV infection by increasing nuclear import of viral DNA. | Cyclophilin B enhances HIV-1 infection.
DeBoer J, Madson CJ, Belshan M., Free PMC Article | 07/16/2016 |
| Cyclophilin B has a high diagnostic value for stomach cancer and its downregulation can effectively inhibit the growth of stomach cancer cells. Thus, cyclophilin B may be a potential therapeutic target for stomach cancer treatment | Expression and role of cyclophilin B in stomach cancer.
Meng DQ, Li PL, Xie M. | 04/16/2016 |
| The extracellular portion of cyclophilin B probably plays an important role in human diseases associated with acute or chronic inflammation | Functional aspects of extracellular cyclophilins.
Hoffmann H, Schiene-Fischer C. | 04/18/2015 |
| Findings demonstrate that CypB prevents hypoxia-induced cell death through modulation of ubiquitin-mediated CHOP protein degradation, suggesting that CypB may have an important role in the tight regulation of CHOP under hypoxia. | Cyclophilin B is involved in p300-mediated degradation of CHOP in tumor cell adaptation to hypoxia.
Jeong K, Kim H, Kim K, Kim SJ, Hahn BS, Jahng GH, Yoon KS, Kim SS, Ha J, Kang I, Choe W., Free PMC Article | 01/17/2015 |
| These findings establish cyclophilin C as an ER cyclophilin, demonstrate the novel involvement of cyclophilins B and C in ER redox homeostasis | Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis.
Stocki P, Chapman DC, Beach LA, Williams DB., Free PMC Article | 12/20/2014 |
| Cyclophilin B is a novel MDM2 interacting partner. | A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2.
Nicholson J, Scherl A, Way L, Blackburn EA, Walkinshaw MD, Ball KL, Hupp TR. | 11/29/2014 |
| cyclophilin B (CypB) is a prolyl isomerase residing in the endoplasmic reticulum (ER), that provides an essential survival signal in glioblastoma multiforme cells through myc and mutant p53 | Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells.
Choi JW, Schroeder MA, Sarkaria JN, Bram RJ., Free PMC Article | 03/22/2014 |
| An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro. | An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1·cartilage-associated protein·cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro.
Ishikawa Y, Bächinger HP., Free PMC Article | 01/4/2014 |
| Cyclophilin B activity regulated secretion and activity of ADAMTS13. | Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat).
Hershko K, Simhadri VL, Blaisdell A, Hunt RC, Newell J, Tseng SC, Hershko AY, Choi JW, Sauna ZE, Wu A, Bram RJ, Komar AA, Kimchi-Sarfaty C., Free PMC Article | 03/30/2013 |
| CypB has an essential function in protecting hepatoma cells against oxidative stress through binding to CD147 and regulating the ERK pathway | Release of overexpressed CypB activates ERK signaling through CD147 binding for hepatoma cell resistance to oxidative stress.
Kim K, Kim H, Jeong K, Jung MH, Hahn BS, Yoon KS, Jin BK, Jahng GH, Kang I, Ha J, Choe W. | 10/20/2012 |
| these findings suggest an unexpected role for cyclophilin B in attenuation of the responses of proinflammatory macrophages | Cyclophilin B attenuates the expression of TNF-α in lipopolysaccharide-stimulated macrophages through the induction of B cell lymphoma-3.
Marcant A, Denys A, Melchior A, Martinez P, Deligny A, Carpentier M, Allain F. | 10/20/2012 |
| CypB interacts with these proteins and is involved in ribosome biogenesis and RNA transcription. | Spatiotemporal behavior of nuclear cyclophilin B indicates a role in RNA transcription.
Dieriks B, Van Oostveldt P. | 08/4/2012 |
| Cyclophilin B is a candidate pancreatic cancer biomarker. | Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker.
Ray P, Rialon-Guevara KL, Veras E, Sullenger BA, White RR., Free PMC Article | 06/30/2012 |
| First report of a unique, multicomponent, high-capacity milk fat reservoir of prolactin as a bilayer-bound complex with cyclophilins A and B in human milk. | A major prolactin-binding complex on human milk fat globule membranes contains cyclophilins A and B: the complex is not the prolactin receptor.
Lorenson MY, Ueda EK, Chen KE, Walker AM. | 04/14/2012 |