| Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer. | Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer.
Arai H, Xiao Y, Millstein J, Wang J, Battaglin F, Kawanishi N, Jayachandran P, Soni S, Zhang W, Mancao C, Salhia B, Mumenthaler SM, Parikh AR, Lenz HJ., Free PMC Article | 02/26/2022 |
| the 1.85 A crystal structure of a large N-terminal segment of human Timeless, spanning amino acids 1-463, is presented and this region of human Timeless harbours a partial binding site for Tipin. | Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.
Holzer S, Degliesposti G, Kilkenny ML, Maslen SL, Matak-Vinkovíc D, Skehel M, Pellegrini L., Free PMC Article | 09/23/2017 |
| TIPIN is important for the maintenance of DNA replication and represents a potential treatment target for the worst prognosis associated breast cancers, such as Triple-negative breast cancer. | TIPIN depletion leads to apoptosis in breast cancer cells.
Baldeyron C, Brisson A, Tesson B, Némati F, Koundrioukoff S, Saliba E, De Koning L, Martel E, Ye M, Rigaill G, Meseure D, Nicolas A, Gentien D, Decaudin D, Debatisse M, Depil S, Cruzalegui F, Pierré A, Roman-Roman S, Tucker GC, Dubois T., Free PMC Article | 08/20/2016 |
| Tim-Tipin complex (or Tim alone) is able to associate with DNA polymerase epsilon bound to a 40-/80-mer DNA ligand. | The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.
Aria V, De Felice M, Di Perna R, Uno S, Masai H, Syväoja JE, van Loon B, Hübscher U, Pisani FM., Free PMC Article | 07/13/2013 |
| Tim-Tipin complex might play a role in coupling DNA unwinding and DNA synthesis by directly affecting the catalytic activities of replication fork proteins. | Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.
Cho WH, Kang YH, An YY, Tappin I, Hurwitz J, Lee JK., Free PMC Article | 04/13/2013 |
| We now show that cellular DNA replication fork pausing and protection factors Timeless (Tim) and Tipin (Timeless-interacting protein) accumulate at OriP during S phase of the cell cycle. | The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus.
Dheekollu J, Lieberman PM., Free PMC Article | 08/6/2011 |
| RPA-covered ssDNA not only supports recruitment and activation of ATR but also, through Tipin and Claspin, it plays an important role in the action of ATR on its critical downstream target Chk1 | Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.
Kemp MG, Akan Z, Yilmaz S, Grillo M, Smith-Roe SL, Kang TH, Cordeiro-Stone M, Kaufmann WK, Abraham RT, Sancar A, Unsal-Kaçmaz K., Free PMC Article | 06/28/2010 |
| The results suggest that Timeless-Tipin functions as a replication fork stabilizer that couples DNA replication with sister chromatid cohesion established at replication forks. | Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion.
Leman AR, Noguchi C, Lee CY, Noguchi E., Free PMC Article | 05/31/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.
Utge SJ, Soronen P, Loukola A, Kronholm E, Ollila HM, Pirkola S, Porkka-Heiskanen T, Partonen T, Paunio T., Free PMC Article | 04/7/2010 |
| observation explains the similar checkpoint phenotypes observed in both Tipin- and Timeless-depleted cells | Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.
Chou DM, Elledge SJ., Free PMC Article | 01/21/2010 |
| These findings indicate that the Tim-Tipin complex mediates the UV-induced intra-S checkpoint, Tim is needed to maintain DNA replication fork movement, Tipin interacts with RPA on DNA. | The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.
Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK., Free PMC Article | 01/21/2010 |
| Tipin is a checkpoint mediator that cooperates with Tim and may regulate the nuclear relocation of Claspin in response to replication checkpoint | Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint.
Yoshizawa-Sugata N, Masai H. | 01/21/2010 |
| TIM and Tipin are functional orthologs of their replisome-associated yeast counterparts capable of coordinating replication with genotoxic stress responses, and distinguishes mammalian TIM from the circadian-specific paralogs. | Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.
Gotter AL, Suppa C, Emanuel BS., Free PMC Article | 01/21/2010 |