| Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability. | Dephosphorylation of the EGFR protein by calcineurin at serine 1046/1047 enhances its stability.
Masaki T, Habara M, Shibutani S, Hanaki S, Sato Y, Tomiyasu H, Shimada M. | 01/21/2023 |
| TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA. | TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
Wang Z, Li H, Wang H, Li X, Zhang Q, Wang H, Li K, Qiu Y., Free PMC Article | 04/23/2022 |
| Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter? | Immunosuppression Affects Neutrophil Functions: Does Calcineurin-NFAT Signaling Matter?
Vymazal O, Bendíčková K, De Zuani M, Vlková M, Hortová-Kohoutková M, Frič J., Free PMC Article | 02/19/2022 |
| PPP3CA truncating variants clustered in the regulatory domain cause early-onset refractory epilepsy. | PPP3CA truncating variants clustered in the regulatory domain cause early-onset refractory epilepsy.
Panneerselvam S, Wang J, Zhu W, Dai H, Pappas JG, Rabin R, Low KJ, Rosenfeld JA, Emrick L, Xiao R, Xia F, Yang Y, Eng CM, Anderson A, Chau V, Soler-Alfonso C, Streff H, Lalani SR, Mercimek-Andrews S, Undiagnosed Diseases Network, DDD Study, Bi W. | 01/1/2022 |
| Calcineurin regulates the stability and activity of estrogen receptor alpha. | Calcineurin regulates the stability and activity of estrogen receptor α.
Masaki T, Habara M, Sato Y, Goshima T, Maeda K, Hanaki S, Shimada M., Free PMC Article | 12/25/2021 |
| Calcineurin. | Calcineurin.
Creamer TP., Free PMC Article | 09/16/2021 |
| Regulation of the Ca(2+)-activated chloride channel Anoctamin-1 (TMEM16A) by Ca(2+)-induced interaction with FKBP12 and calcineurin. | Regulation of the Ca(2+)-activated chloride channel Anoctamin-1 (TMEM16A) by Ca(2+)-induced interaction with FKBP12 and calcineurin.
Sánchez-Solano A, Corral N, Segura-Covarrubias G, Guzmán-Hernández ML, Arechiga-Figueroa I, Cruz-Rangel S, Pérez-Cornejo P, Arreola J. | 08/7/2021 |
| Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder. | Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder.
Kunii Y, Hino M, Matsumoto J, Nagaoka A, Nawa H, Kakita A, Akatsu H, Hashizume Y, Yabe H., Free PMC Article | 11/21/2020 |
| Calcineurin functions as a positive and negative modulator of gene transcription. | Calcineurin controls gene transcription following stimulation of a Gαq-coupled designer receptor.
Langfermann DS, Schmidt T, Rössler OG, Thiel G. | 07/4/2020 |
| Solution NMR shows that the P84A calcineurin Aalpha mutant exists in two forms, compatible with cis-trans isomers, while the P309A mutant is predominantly in the trans conformation | Cis-trans proline isomers in the catalytic domain of calcineurin.
Teixeira JMC, Guasch A, Biçer A, Aranguren-Ibáñez Á, Chashmniam S, Paniagua JC, Pérez-Riba M, Fita I, Pons M. | 05/2/2020 |
| Bmp2 is a downstream target of the calcineurin/NFAT pathway in lung endothelium, potently inhibiting cancer cell growth by stimulating differentiation. | Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2.
Hendrikx S, Coso S, Prat-Luri B, Wetterwald L, Sabine A, Franco CA, Nassiri S, Zangger N, Gerhardt H, Delorenzi M, Petrova TV. | 03/14/2020 |
| Overexpression of a constitutively active PPP3CA form, but not its catalytically inactive counterpart, inhibited HIF activity and expression of HIF target genes but did not affect HIF-1alpha or HIF-2alpha expression | Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity.
Karagiota A, Mylonis I, Simos G, Chachami G. | 02/15/2020 |
| CN is significantly upregulated in ovarian cancer tissues with later-stage CN levels may be investigated for use as a prognostic biomarker for risk assessment in unique subtype of ovarian cancer patients. | Higher expression of calcineurin predicts poor prognosis in unique subtype of ovarian cancer.
Xin B, Ji KQ, Liu YS, Zhao XD., Free PMC Article | 01/11/2020 |
| Gln442Ter mutation causes epilepsy, constitutive enzyme activation and downregulation of protein expression. | Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression.
Rydzanicz M, Wachowska M, Cook EC, Lisowski P, Kuźniewska B, Szymańska K, Diecke S, Prigione A, Szczałuba K, Szybińska A, Koppolu A, Murcia Pienkowski V, Kosińska J, Wiweger M, Kostrzewa G, Brzozowska M, Domańska-Pakieła D, Jurkiewicz E, Stawiński P, Gromadka A, Zielenkiewicz P, Demkow U, Dziembowska M, Kuźnicki J, Creamer TP, Płoski R., Free PMC Article | 04/13/2019 |
| Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders. | Loss-of-function and gain-of-function mutations in PPP3CA cause two distinct disorders.
Mizuguchi T, Nakashima M, Kato M, Okamoto N, Kurahashi H, Ekhilevitch N, Shiina M, Nishimura G, Shibata T, Matsuo M, Ikeda T, Ogata K, Tsuchida N, Mitsuhashi S, Miyatake S, Takata A, Miyake N, Hata K, Kaname T, Matsubara Y, Saitsu H, Matsumoto N. | 02/9/2019 |
| The underlying mechanism forAT1-autoantibody induced podocyte damage might involve activation of the TRPC6 -calcium/calcineurin pathway. | Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6- Calcium/Calcineurin Pathway in Pre-Eclampsia.
Yu Y, Zhang L, Xu G, Wu Z, Li Q, Gu Y, Niu J. | 01/12/2019 |
| A short-linear interaction motif between residues 337-343 of AKAP79 is the sole PP2B-anchoring determinant sustaining these diverse topologies. | Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity.
Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD., Free PMC Article | 06/9/2018 |
| Mutation in PPP3CA gene is associated with Severe Neurodevelopmental Disease with Seizures. | De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures.
Myers CT, Stong N, Mountier EI, Helbig KL, Freytag S, Sullivan JE, Ben Zeev B, Nissenkorn A, Tzadok M, Heimer G, Shinde DN, Rezazadeh A, Regan BM, Oliver KL, Ernst ME, Lippa NC, Mulhern MS, Ren Z, Poduri A, Andrade DM, Bird LM, Bahlo M, Berkovic SF, Lowenstein DH, Scheffer IE, Sadleir LG, Goldstein DB, Mefford HC, Heinzen EL., Free PMC Article | 10/21/2017 |
| identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)LAVP(465), which competitively inhibits substrate dephosphorylation. In vitro and cell-based assays revealed that the CNAbeta1-containing holoenzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD and LAVP, which block substrate access to the substrate-binding groove. | The unique C terminus of the calcineurin isoform CNAβ1 confers non-canonical regulation of enzyme activity by Ca(2+) and calmodulin.
Bond R, Ly N, Cyert MS., Free PMC Article | 10/14/2017 |
| Studies indicate the importance of the AKAP79/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 region of the hippocampus. | Regulation of the phosphatase PP2B by protein-protein interactions.
Nygren PJ, Scott JD., Free PMC Article | 07/15/2017 |
| Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons. | Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.
Yao JJ, Zhao QR, Liu DD, Chow CW, Mei YA., Free PMC Article | 05/7/2017 |
| CN-A and nephrin were clearly reduced in the kidneys of a 10-year-old boy who had relapsing steroid-resistant nephrotic syndrome. | Role of calcineurin (CN) in kidney glomerular podocyte: CN inhibitor ameliorated proteinuria by inhibiting the redistribution of CN at the slit diaphragm.
Wakamatsu A, Fukusumi Y, Hasegawa E, Tomita M, Watanabe T, Narita I, Kawachi H., Free PMC Article | 10/1/2016 |
| that KIF1Bbeta affects mitochondrial dynamics through calcineurin-dependent dephosphorylation of Dynamin-related protein 1 (DRP1), causing mitochondrial fission and apoptosis | The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.
Li S, Fell SM, Surova O, Smedler E, Wallis K, Chen ZX, Hellman U, Johnsen JI, Martinsson T, Kenchappa RS, Uhlén P, Kogner P, Schlisio S. | 06/4/2016 |
| for Aspergillus fumigatus, activation of macrophage calcineurin-NFAT occurs via a phagosomal TLR9-dependent and Bruton's tyrosine kinase-dependent signalling pathway that is independent of MyD88 | Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.
Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell MA, Saijo S, Mostowy S, Shaunak S, Armstrong-James D., Free PMC Article | 11/7/2015 |
| Data indicate that both nuclear factors of activated T cells (NFATs) motifs partially compete for binding but do not fully displace each other on the calcineurin (Cn) epitope. | The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.
Gal M, Li S, Luna RE, Takeuchi K, Wagner G., Free PMC Article | 05/16/2015 |