| FERMT1 promotes cell migration and invasion in non-small cell lung cancer via regulating PKP3-mediated activation of p38 MAPK signaling. | FERMT1 promotes cell migration and invasion in non-small cell lung cancer via regulating PKP3-mediated activation of p38 MAPK signaling.
Liu B, Feng Y, Xie N, Yang Y, Yang D., Free PMC Article | 01/16/2024 |
| FERMT1 Is a Prognostic Marker Involved in Immune Infiltration of Pancreatic Adenocarcinoma Correlating with m[6]A Modification and Necroptosis. | FERMT1 Is a Prognostic Marker Involved in Immune Infiltration of Pancreatic Adenocarcinoma Correlating with m(6)A Modification and Necroptosis.
Wu Q, Li J, Wang P, Peng Q, Kang Z, Deng Y, Li J, Yan D, Ge F, Chen Y., Free PMC Article | 03/30/2023 |
| Characterization of Amino Acid Substitutions and Deletions in Kindlin-1 FERM Domain: Relevance for Precision Medicine. | Characterization of Amino Acid Substitutions and Deletions in Kindlin-1 FERM Domain: Relevance for Precision Medicine.
Yilmaz P, Marek SJ, Valari M, He Y, Has C. | 08/27/2022 |
| Kindlin-1 modulates the EGFR pathway and predicts sensitivity to EGFR inhibitors across cancer types. | Kindlin-1 modulates the EGFR pathway and predicts sensitivity to EGFR inhibitors across cancer types.
Azorin P, Bonin F, Tariq Z, Petitalot A, Coussy F, Marangoni E, Becette V, Denoux Y, Vincent-Salomon A, Le Tourneau C, Larbi Cherif L, Klijanienko J, Kamal M, Bièche I, Lidereau R, Driouch K., Free PMC Article | 05/7/2022 |
| FERMT1 knockdown inhibits oral squamous cell carcinoma cell epithelial-mesenchymal transition by inactivating the PI3K/AKT signaling pathway. | FERMT1 knockdown inhibits oral squamous cell carcinoma cell epithelial-mesenchymal transition by inactivating the PI3K/AKT signaling pathway.
Wang X, Chen Q., Free PMC Article | 12/18/2021 |
| FERMT1 promotes gastric cancer progression by activating the NF-kappaB pathway and predicts poor prognosis. | FERMT1 promotes gastric cancer progression by activating the NF-κB pathway and predicts poor prognosis.
Fan H, Zhang S, Zhang Y, Liang W, Cao B., Free PMC Article | 10/23/2021 |
| Examination of FERMT1 expression in placental chorionic villi and its role in HTR8-SVneo cell invasion. | Examination of FERMT1 expression in placental chorionic villi and its role in HTR8-SVneo cell invasion.
Kawamura E, Hamilton GB, Miskiewicz EI, MacPhee DJ. | 09/4/2021 |
| Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions. | Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions.
Orré T, Joly A, Karatas Z, Kastberger B, Cabriel C, Böttcher RT, Lévêque-Fort S, Sibarita JB, Fässler R, Wehrle-Haller B, Rossier O, Giannone G., Free PMC Article | 06/19/2021 |
| A novel pathogenic FERMT1 variant in four families with Kindler syndrome in Argentina. | A novel pathogenic FERMT1 variant in four families with Kindler syndrome in Argentina.
Valinotto LE, Natale MI, Lusso SB, Cella E, Gutiérrez O, Sebastiani F, Manzur GB. | 04/17/2021 |
| Study shows that skin and keratinocytes from Kindler syndrome patients have significantly reduced expression levels of the EGFR, resulting in defective EGF-dependent signaling and cell migration. Kindlin-1 can associate directly with EGFR in vitro and in keratinocytes in an EGF-dependent manner and formation of this complex protect EGFR from lysosomal-mediated degradation and required for EGF-dependent migration. | Kindlin-1 Regulates Epidermal Growth Factor Receptor Signaling.
Michael M, Begum R, Chan GK, Whitewood AJ, Matthews DR, Goult BT, McGrath JA, Parsons M., Free PMC Article | 01/4/2020 |
| indicate that FERMT1 acts as an oncogene and is negatively regulated by miR-24 | The Effect of FERMT1 Regulated by miR-24 on the Growth and Radiation Resistance of Esophageal Cancer.
Yan Q, Chen T, Yang H, Yu H, Zheng Y, He T, Wang J. | 06/15/2019 |
| Kindlin-1 is mainly expressed in the cytoplasm of normal esophageal squamous epithelium and Esophageal cancer (EC) cells. Kindlin-1 expression is positively correlated with tumor cell differentiation and is higher in stage I tumors. Kindlin-1 expression is higher in non-smoker patients than in smoker patients, and in patients with a family history of EC. | Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology.
Wang P, Zhan J, Song J, Wang Y, Fang W, Liu Z, Zhang H. | 07/14/2018 |
| Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin. | Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin.
Gao J, Huang M, Lai J, Mao K, Sun P, Cao Z, Hu Y, Zhang Y, Schulte ML, Jin C, Wang J, White GC, Xu Z, Ma YQ., Free PMC Article | 06/16/2018 |
| we demonstrated that Kindlin-1 promotes CRC progression by recruiting SARA and Smad3 to TbetaRI and thereby activates TGF-beta/Smad3 signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta/Smad3 signaling and may also be a potential target for CRC therapeutics. | Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells.
Kong J, Du J, Wang Y, Yang M, Gao J, Wei X, Fang W, Zhan J, Zhang H., Free PMC Article | 02/10/2018 |
| Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions | Two novel mutations in KIND1 in Indian patients with Kindler syndrome.
Kantheti P, Kubba A, Prabhu A, Batrani M, Hiremagalore R. | 02/10/2018 |
| KS patients' periodontal disease activity could be taken under control with regular follow-up. | Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree.
Yıldırım TT, Kaya FA, Taşkesen M, Dündar S, Bozoğlan A, Tekin GG, Akdeniz S. | 12/9/2017 |
| these data define a novel role for Kin1 in microtubule acetylation and stability | Kindlin1 regulates microtubule function to ensure normal mitosis.
Patel H, Stavrou I, Shrestha RL, Draviam V, Frame MC, Brunton VG., Free PMC Article | 09/30/2017 |
| keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding. | Kindlin-1 Regulates Keratinocyte Electrotaxis.
Zhang G, Gu Y, Begum R, Chen H, Gao X, McGrath JA, Parsons M, Song B., Free PMC Article | 09/16/2017 |
| FERMT1 activates the beta-catenin transcriptional activity to promote EMT in CC metastasis. | FERMT1 mediates epithelial-mesenchymal transition to promote colon cancer metastasis via modulation of β-catenin transcriptional activity.
Liu CC, Cai DL, Sun F, Wu ZH, Yue B, Zhao SL, Wu XS, Zhang M, Zhu XW, Peng ZH, Yan DW. | 09/2/2017 |
| KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage. | KIND1 Loss Sensitizes Keratinocytes to UV-Induced Inflammatory Response and DNA Damage.
Zhang X, Luo S, Wu J, Zhang L, Wang WH, Degan S, Erdmann D, Hall R, Zhang JY., Free PMC Article | 07/22/2017 |
| We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 overexpression has no compensatory effect. | UV-B-induced cutaneous inflammation and prospects for antioxidant treatment in Kindler syndrome.
Maier K, He Y, Wölfle U, Esser PR, Brummer T, Schempp C, Bruckner-Tuderman L, Has C. | 06/10/2017 |
| These results indicate that Kindlin-1 is essential in EGF-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF in the treatment of acute wounds. | Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing.
Shen C, Sun L, Zhu N, Qi F., Free PMC Article | 04/29/2017 |
| KS is caused by mutations in the FERMT1 gene. Including the present, more than 60 mutations in FERMT1 have been identified since 2003. In spite of the expanding FERMT1 mutation database, there seems to be a lack of a clear genotype-phenotype correlation in KS | A novel mutation in the FERMT1 gene in Turkish siblings with Kindler syndrome.
Kartal D, Borlu M, Has C, Fölster-Holst R. | 04/29/2017 |
| A nonsense mutation in Exon 5 of KIND1 Gene in an Iranian Family may lead to incomplete and non-functional protein products and is pathogenic and has meaningful implications for the diagnosis of patients with Kindler syndrome. | A Novel Nonsense Mutation in Exon 5 of KIND1 Gene in an Iranian Family with Kindler Syndrome.
Heidari MM, Khatami M, Kargar S, Azari M, Hoseinzadeh H, Fallah H. | 03/4/2017 |
| we show that a certain number of KS patients may harbor FERMT1 transcriptional regulatory mutations which are not routinely detected. | FERMT1 promoter mutations in patients with Kindler syndrome.
Has C, Chmel N, Levati L, Neri I, Sonnenwald T, Pigors M, Godbole K, Dudhbhate A, Bruckner-Tuderman L, Zambruno G, Castiglia D. | 05/14/2016 |