| Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures. | Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures.
Jubelin C, Muñoz-Garcia J, Ollivier E, Cochonneau D, Vallette F, Heymann MF, Oliver L, Heymann D. | 03/5/2024 |
| Chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4[+] helper and CD8[+] effector T cells. | Chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4(+) helper and CD8(+) effector T cells.
Azevedo-Pouly AC, Appell LE, Burdine L, Rogers LJ, Morehead LC, Fil D, Barker M, Rainwater RR, Waldrip ZJ, Koss B, Burdine MS., | 08/3/2023 |
| Up-regulation of PRKDC was associated with poor renal dysfunction after renal transplantation: A multi-centre analysis. | Up-regulation of PRKDC was associated with poor renal dysfunction after renal transplantation: A multi-centre analysis.
Cao Z, Jiang H, Zhao C, Zhou H, Ma Z, Xu C, Zhang J, Jiang M, Wang Z., Free PMC Article | 05/17/2023 |
| FAP is critical for ovarian cancer cell survival by sustaining NF-kappaB activation through recruitment of PRKDC in lipid rafts. | FAP is critical for ovarian cancer cell survival by sustaining NF-κB activation through recruitment of PRKDC in lipid rafts.
Li B, Ding Z, Calbay O, Li Y, Li T, Jin L, Huang S., Free PMC Article | 04/19/2023 |
| DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma. | DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma.
Taffoni C, Marines J, Chamma H, Guha S, Saccas M, Bouzid A, Valadao AC, Maghe C, Jardine J, Park MK, Polak K, De Martino M, Vanpouille-Box C, Del Rio M, Gongora C, Gavard J, Bidère N, Song MS, Pineau D, Hugnot JP, Kissa K, Fontenille L, Blanchet FP, Vila IK, Laguette N., Free PMC Article | 04/6/2023 |
| DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism. | DNA-PKcs and ATM modulate mitochondrial ADP-ATP exchange as an oxidative stress checkpoint mechanism.
Chen WM, Chiang JC, Shang Z, Palchik G, Newman C, Zhang Y, Davis AJ, Lee H, Chen BP., Free PMC Article | 03/22/2023 |
| DNA-PK hyperactivation occurs in deletion 11q chronic lymphocytic leukemia and is both a biomarker and therapeutic target for drug-resistant disease. | DNA-PK hyperactivation occurs in deletion 11q chronic lymphocytic leukemia and is both a biomarker and therapeutic target for drug-resistant disease.
Kost SEF, Saleh A, Yuan SH, Kuzio B, Gibson SB, Yang L, Banerji V, Johnston JB, Katyal S., Free PMC Article | 02/4/2023 |
| Structural analysis of the basal state of the Artemis:DNA-PKcs complex. | Structural analysis of the basal state of the Artemis:DNA-PKcs complex.
Watanabe G, Lieber MR, Williams DR., Free PMC Article | 07/30/2022 |
| Potential value of PRKDC as a therapeutic target and prognostic biomarker in pan-cancer. | Potential value of PRKDC as a therapeutic target and prognostic biomarker in pan-cancer.
Yang X, Yang F, Lan L, Wen N, Li H, Sun X., Free PMC Article | 07/16/2022 |
| PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA. | PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA.
Fan Y, Liang Y, Liu Y, Fan H., Free PMC Article | 04/30/2022 |
| DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury. | DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury.
Wang S, Zhu H, Li R, Mui D, Toan S, Chang X, Zhou H. | 04/9/2022 |
| Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer. | Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer.
Pálinkás HL, Pongor L, Balajti M, Nagy Á, Nagy K, Békési A, Bianchini G, Vértessy BG, Győrffy B., Free PMC Article | 02/26/2022 |
| Opposite effects of the triple target (DNA-PK/PI3K/mTOR) inhibitor PI-103 on the radiation sensitivity of glioblastoma cell lines proficient and deficient in DNA-PKcs. | Opposite effects of the triple target (DNA-PK/PI3K/mTOR) inhibitor PI-103 on the radiation sensitivity of glioblastoma cell lines proficient and deficient in DNA-PKcs.
Djuzenova CS, Fischer T, Katzer A, Sisario D, Korsa T, Steussloff G, Sukhorukov VL, Flentje M., Free PMC Article | 02/26/2022 |
| HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia. | HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia.
Yang Y, Lu H, Chen C, Lyu Y, Cole RN, Semenza GL., Free PMC Article | 02/19/2022 |
| Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Liu L, Chen X, Li J, Wang H, Buehl CJ, Goff NJ, Meek K, Yang W, Gellert M., Free PMC Article | 02/19/2022 |
| DUSP6 regulates radiosensitivity in glioblastoma by modulating the recruitment of phosphorylated DNAPKcs at DNA double-strand breaks. | DUSP6 regulates radiosensitivity in glioblastoma by modulating the recruitment of phosphorylated DNAPKcs at DNA double-strand breaks.
Nair J, Basha Syed S, Mahaddalkar T, Ketkar M, Thorat R, Sastri Goda J, Dutt S. | 02/5/2022 |
| X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. | X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology.
Hammel M, Tainer JA., Free PMC Article | 02/5/2022 |
| DNA repair proteins cooperate with SOX2 in regulating the transition of human embryonic stem cells to neural progenitor cells. | DNA repair proteins cooperate with SOX2 in regulating the transition of human embryonic stem cells to neural progenitor cells.
Chen W, Chen X, Zhang X, Chen C, Dan S, Hu J, Kang B, Wang YJ. | 01/15/2022 |
| The depletion of Circ-PRKDC enhances autophagy and apoptosis in T-cell acute lymphoblastic leukemia via microRNA-653-5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway. | The depletion of Circ-PRKDC enhances autophagy and apoptosis in T-cell acute lymphoblastic leukemia via microRNA-653-5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway.
Ling Z, Fang ZG, Wu JY, Liu JJ. | 01/8/2022 |
| miRNA-218-5p increases cell sensitivity by inhibiting PRKDC activity in radiation-resistant lung carcinoma cells. | miRNA-218-5p increases cell sensitivity by inhibiting PRKDC activity in radiation-resistant lung carcinoma cells.
Chen X, Xu Y, Jiang L, Tan Q., Free PMC Article | 12/25/2021 |
| Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80. | Kinetochore protein MAD1 participates in the DNA damage response through ataxia-telangiectasia mutated kinase-mediated phosphorylation and enhanced interaction with KU80.
Xiao M, Li X, Su Y, Liu Z, Han Y, Wang S, Zeng Q, Liu H, Hao J, Xu B., Free PMC Article | 12/4/2021 |
| DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. | DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells.
Waldrip ZJ, Burdine L, Harrison DK, Azevedo-Pouly AC, Storey AJ, Moffett OG, Mackintosh SG, Burdine MS., Free PMC Article | 11/27/2021 |
| Role of DNA-Dependent Protein Kinase in Mediating Cyst Growth in Autosomal Dominant Polycystic Kidney Disease. | Role of DNA-Dependent Protein Kinase in Mediating Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.
Chandra AN, Saravanabavan S, Rangan GK., Free PMC Article | 11/6/2021 |
| DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy. | DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
Puustinen P, Keldsbo A, Corcelle-Termeau E, Ngoei K, Sønder SL, Farkas T, Kaae Andersen K, Oakhill JS, Jäättelä M., Free PMC Article | 10/2/2021 |
| Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses. | Inhibition of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) stimulates osteoblastogenesis by potentiating bone morphogenetic protein 2 (BMP2) responses.
Farhat T, Dudakovic A, Chung JH, van Wijnen AJ, St-Arnaud R., Free PMC Article | 09/11/2021 |