| UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1. | UBQLN1 deficiency mediates telomere shortening and IPF through interacting with RPA1.
Zhou H, Xie C, Xie Y, He Y, Chen Y, Zhang C, Zhang Y, Zhao Y, Liu H., Free PMC Article | 08/4/2023 |
| Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury. | Hepatocyte CD36 modulates UBQLN1-mediated proteasomal degradation of autophagic SNARE proteins contributing to septic liver injury.
Li Y, Xu J, Chen W, Wang X, Zhao Z, Li Y, Zhang L, Jiao J, Yang Q, Ding Q, Yang P, Wei L, Chen Y, Chen Y, Ruan XZ, Zhao L., Free PMC Article | 08/3/2023 |
| GABAA Receptor-Stabilizing Protein Ubqln1 Affects Hyperexcitability and Epileptogenesis after Traumatic Brain Injury and in a Model of In Vitro Epilepsy in Mice. | GABA(A) Receptor-Stabilizing Protein Ubqln1 Affects Hyperexcitability and Epileptogenesis after Traumatic Brain Injury and in a Model of In Vitro Epilepsy in Mice.
Kürten T, Ihbe N, Ueberbach T, Distler U, Sielaff M, Tenzer S, Mittmann T., Free PMC Article | 04/23/2022 |
| miR-337-5p promotes the development of cardiac hypertrophy by targeting Ubiquilin-1 (UBQLN1). | miR-337-5p promotes the development of cardiac hypertrophy by targeting Ubiquilin-1 (UBQLN1).
Ding Y, Wang J, Lu J., Free PMC Article | 01/22/2022 |
| Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD. | Overexpression of UBQLN1 reduces neuropathology in the P497S UBQLN2 mouse model of ALS/FTD.
Wang S, Tatman M, Monteiro MJ., Free PMC Article | 06/5/2021 |
| The results of this study revealed that hypoxia-ischemic decreased the expression of Ubqln, thus may provide a novel understanding of role of Ubqln in neonatal hypoxic ischemic encephalopathy. | Decreased expression of ubiquilin‑1 following neonatal hypoxia‑ischemic brain injury in mice.
Luo L, Liu Y, Tu X, Ren X, Zhao W, Liu J, Zhang L, Chen W, Zhang P, Wang W, Lü L, Wang M., Free PMC Article | 08/31/2019 |
| Post-ischemic overexpression of Ubqln1 significantly promoted functional recovery. | Enhanced Proteostasis in Post-ischemic Stroke Mouse Brains by Ubiquilin-1 Promotes Functional Recovery.
Liu Y, Qiao F, Wang H., Free PMC Article | 07/14/2018 |
| This study provide strong evidence showing that Ubqln1 plays a crucial role in modulating learning and memory function in different cohorts of transgenic mice. | Overexpression of Ubiquilin-1 Alleviates Alzheimer's Disease-Caused Cognitive and Motor Deficits and Reduces Amyloid-β Accumulation in Mice.
Adegoke OO, Qiao F, Liu Y, Longley K, Feng S, Wang H., Free PMC Article | 04/14/2018 |
| Reduced body weight gain in mice, overexpressing Ubqln1 was associated with upregulation of SIRT1 and AMPK. | Reduced body weight gain in ubiquilin-1 transgenic mice is associated with increased expression of energy-sensing proteins.
Qiao F, Longley KR, Feng S, Schnack S, Gao H, Li Y, Schlenker EH, Wang H., Free PMC Article | 02/3/2018 |
| Results suggest that ubiquilin-1 may mechanistically participate in Alzheimer's disease molecular pathogenesis by affecting BACE1 and thereby APP processing and Abeta accumulation | Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KMA, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M. | 09/24/2016 |
| propose a model in which UBQLN1 recognizes Mycobacterium tuberculosis and in turn recruits the autophagy machinery thereby promoting intracellular control of Mycobacterium tuberculosis | Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of Mycobacterium tuberculosis.
Sakowski ET, Koster S, Portal Celhay C, Park HS, Shrestha E, Hetzenecker SE, Maurer K, Cadwell K, Philips JA., Free PMC Article | 04/9/2016 |
| Ubqln protects mice from oxidative stress and ischemic stroke-caused neuronal injury through facilitating removal of damaged proteins | Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice.
Liu Y, Lü L, Hettinger CL, Dong G, Zhang D, Rezvani K, Wang X, Wang H., Free PMC Article | 04/12/2014 |
| results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions | Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.
Rutherford NJ, Lewis J, Clippinger AK, Thomas MA, Adamson J, Cruz PE, Cannon A, Xu G, Golde TE, Shaw G, Borchelt DR, Giasson BI., Free PMC Article | 03/15/2014 |
| Interactions between UBQLN1 and SPEM1 suggest a role in the regulation of protein ubiquitination during spermiogenesis. | UBQLN1 interacts with SPEM1 and participates in spermiogenesis.
Bao J, Zhang J, Zheng H, Xu C, Yan W., Free PMC Article | 01/22/2011 |
| UBQLN1-transfected cells did not show increased starvation-induced cell death | PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.
N'Diaye EN, Kajihara KK, Hsieh I, Morisaki H, Debnath J, Brown EJ., Free PMC Article | 01/21/2010 |
| Described results suggest that ubiquilin proteins play an important role in regulating presenilin 2 (PS2) protein levels in cells. | Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins.
Massey LK, Mah AL, Ford DL, Miller J, Liang J, Doong H, Monteiro MJ. | 04/20/2005 |