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    PROC protein C, inactivator of coagulation factors Va and VIIIa [ Homo sapiens (human) ]

    Gene ID: 5624, updated on 24-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Analysis of PROC mutations and clinical features in 22 unrelated families with inherited protein C deficiency.

    Analysis of PROC mutations and clinical features in 22 unrelated families with inherited protein C deficiency.
    Xu F, Zhang K, Xu Q, Ye L, Zeng M, Jin Y, Wang M, Yang L.

    02/1/2024
    Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C.

    Computational analysis of the functional and structural impact of the most deleterious missense mutations in the human Protein C.
    Farajzadeh-Dehkordi M, Mafakher L, Harifi A, Samiee-Rad F, Rahmani B., Free PMC Article

    01/31/2024
    Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3.

    Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3.
    Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV.

    01/3/2024
    Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3.

    Design and characterization of novel activated protein C variants for the proteolysis of cytotoxic extracellular histone H3.
    Huckriede JB, Beurskens DMH, Wildhagen KCCA, Reutelingsperger CPM, Wichapong K, Nicolaes GAF.

    12/15/2023
    Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.

    Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.
    Li X, Song X, Mahmood DFD, Sim MMS, Bidarian SJ, Wood JP.,

    10/10/2023
    APC ameliorates idiopathic membranous nephropathy by affecting podocyte apoptosis through the ERK1/2/YB-1/PLA2R1 axis.

    APC ameliorates idiopathic membranous nephropathy by affecting podocyte apoptosis through the ERK1/2/YB-1/PLA2R1 axis.
    Ke B, Shen W, Liao Y, Hu J, Tu W, Fang X., Free PMC Article

    08/9/2023
    Protein C and S levels in patients with Thalassemia intermedia.

    Protein C and S levels in patients with Thalassemia intermedia.
    Mohammed NS., Free PMC Article

    01/14/2023
    Pediatric Retinal Detachment in Homozygous Protein C Deficiency: Genetic and Phenotypic Description of a Single Family.

    Pediatric Retinal Detachment in Homozygous Protein C Deficiency: Genetic and Phenotypic Description of a Single Family.
    Alotaibi MD, Albakri AS, Alsulaiman SM.

    05/28/2022
    [Clinical phenotype and gene mutation analysis of 12 patients with hereditary protein C deficiency in different families].

    [Clinical phenotype and gene mutation analysis of 12 patients with hereditary protein C deficiency in different families].
    Xu QY, Yang LL, Xie HX, Jin YH, Li XL, Zhou XX, Liu MN, Wang MS., Free PMC Article

    03/5/2022
    Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2.

    Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2.
    Xue M, Lin H, Zhao R, Fryer C, March L, Jackson CJ., Free PMC Article

    02/19/2022
    How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen.

    How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen.
    Peacock RB, McGrann T, Zaragoza S, Komives EA., Free PMC Article

    02/19/2022
    Protein C Promotor Haplotypes Associated with Large-Artery Atherosclerosis Stroke in Iranian Population.

    Protein C Promotor Haplotypes Associated with Large-Artery Atherosclerosis Stroke in Iranian Population.
    Meshkani SE, Fasihi A, Badakhshan F, Zahedi M, Goudarzian M, Ramazi S.

    02/5/2022
    The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis.

    The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis.
    Catenacci V, Sheikh F, Patel K, Fox-Robichaud AE., Free PMC Article

    01/29/2022
    Two heterozygous mutations associated with type I protein C deficiency in two Chinese independent families.

    Two heterozygous mutations associated with type I protein C deficiency in two Chinese independent families.
    Xu Q, Wang M, Jin Y, Liu S, Luo S, Yang L.

    01/22/2022
    Association between Circulating Protein C Levels and Incident Dementia: The Atherosclerosis Risk in Communities Study.

    Association between Circulating Protein C Levels and Incident Dementia: The Atherosclerosis Risk in Communities Study.
    Tin A, Walker KA, Bressler J, Windham BG, Griswold M, Sullivan K, Wu A, Gottesman R, Fornage M, Coresh J, Sharrett AR, Folsom AR, Mosley TH., Free PMC Article

    11/6/2021
    MiR-124 and miR-506 are involved in the decline of protein C in children with extra-hepatic portal vein obstruction.

    MiR-124 and miR-506 are involved in the decline of protein C in children with extra-hepatic portal vein obstruction.
    Zhang JS, Li L., Free PMC Article

    10/23/2021
    Severe Protein C Deficiency due to Novel Biallelic Variants in PROC and Their Phenotype Correlation.

    Severe Protein C Deficiency due to Novel Biallelic Variants in PROC and Their Phenotype Correlation.
    Barg AA, Dardik R, Levin C, Koren A, Levy-Mendelovich S, Pode-Shakked B, Kenet G.

    08/14/2021
    Genotype-Phenotype Relationships in a Large French Cohort of Subjects with Inherited Protein C Deficiency.

    Genotype-Phenotype Relationships in a Large French Cohort of Subjects with Inherited Protein C Deficiency.
    Alhenc-Gelas M, Plu-Bureau G, Mauge L, Gandrille S, Présot I, GFHT Study Group on Genetic Thrombophilia.

    07/31/2021
    Protein C deficiency; PROC gene variants in a Danish population.

    Protein C deficiency; PROC gene variants in a Danish population.
    Winther-Larsen A, Kjaergaard AD, Larsen OH, Hvas AM, Nissen PH.

    07/17/2021
    Burden of rare exome sequence variants in PROC gene is associated with venous thromboembolism: a population-based study.

    Burden of rare exome sequence variants in PROC gene is associated with venous thromboembolism: a population-based study.
    Tang W, Stimson MR, Basu S, Heckbert SR, Cushman M, Pankow JS, Folsom AR, Pankratz N., Free PMC Article

    06/19/2021
    Recurrent PROC and novel PROS1 mutations in Vietnamese patients diagnosed with idiopathic deep venous thrombosis.

    Recurrent PROC and novel PROS1 mutations in Vietnamese patients diagnosed with idiopathic deep venous thrombosis.
    Do MD, Pham DV, Le LP, Gia Le LH, Minh Tran LB, Dang Huynh MD, Do QM, Vu HA, Nguyen NH, Mai TP.

    06/12/2021
    Ile73Asn mutation in protein C introduces a new N-linked glycosylation site on the first EGF-domain of protein C and causes thrombosis.

    Ile73Asn mutation in protein C introduces a new N-linked glycosylation site on the first EGF-domain of protein C and causes thrombosis.
    Lu Y, Mehta-D'souza P, Biswas I, Villoutreix BO, Wang X, Ding Q, Rezaie AR., Free PMC Article

    05/8/2021
    [Genetic and Clinical Characteristics of A Family with Combined PROC and PROS1 Genetic Variants].

    [Genetic and Clinical Characteristics of A Family with Combined PROC and PROS1 Genetic Variants].
    Wang X, Sheng GY, Zhang W, Zhao YX, Xia LJ, Jiang M.

    04/13/2021
    Increase of Neutrophil Activation Markers in Venous Thrombosis-Contribution of Circulating Activated Protein C.

    Increase of Neutrophil Activation Markers in Venous Thrombosis-Contribution of Circulating Activated Protein C.
    Martos L, Oto J, Fernández-Pardo Á, Plana E, Solmoirago MJ, Cana F, Hervás D, Bonanad S, Ferrando F, España F, Navarro S, Medina P., Free PMC Article

    02/20/2021
    Compound heterozygous protein C variants undetectable by common laboratory testing causing purpura fulminans after the neonatal period.

    Compound heterozygous protein C variants undetectable by common laboratory testing causing purpura fulminans after the neonatal period.
    MacQuarrie KL, Williams O, Friedman KD, Bercovitz RS.

    12/5/2020
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