| PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer. | PARD3 drives tumorigenesis through activating Sonic Hedgehog signalling in tumour-initiating cells in liver cancer.
Wu J, Tan HY, Chan YT, Lu Y, Feng Z, Yuan H, Zhang C, Feng Y, Wang N., Free PMC Article | 03/11/2024 |
| Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer. | Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer.
Gunji D, Narumi R, Muraoka S, Isoyama J, Ikemoto N, Ishida M, Tomonaga T, Sakai Y, Obama K, Adachi J. | 09/27/2023 |
| Polarity protein Par3 sensitizes breast cancer to paclitaxel by promoting cell cycle arrest. | Polarity protein Par3 sensitizes breast cancer to paclitaxel by promoting cell cycle arrest.
Zhao Y, Peng H, Liang L, Li Y, Hu X, Wang B, Xu Y, Chen S. | 02/19/2022 |
| Par-3 family proteins in cell polarity & adhesion. | Par-3 family proteins in cell polarity & adhesion.
Thompson BJ., Free PMC Article | 02/19/2022 |
| The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma. | The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma.
Dadras MS, Caja L, Mezheyeuski A, Liu S, Gélabert C, Gomez-Puerto MC, Gallini R, Rubin CJ, Ten Dijke P, Heldin CH, Moustakas A., Free PMC Article | 02/5/2022 |
| Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex. | Plakophilin 3 and Par3 facilitate desmosomes' association with the apical junctional complex.
Indra I, Troyanovsky RB, Green KJ, Troyanovsky SM., Free PMC Article | 01/29/2022 |
| Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl. | Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl.
Tocan V, Hayase J, Kamakura S, Kohda A, Ohga S, Kohjima M, Sumimoto H., Free PMC Article | 01/29/2022 |
| Par3/integrin beta1 regulates embryo adhesion via changing endometrial luminal epithelium polaritydagger. | Par3/integrin β1 regulates embryo adhesion via changing endometrial luminal epithelium polarity†.
Peng J, Li X, Zhang Y, Hu J, Shang Y, Yin Y, Xiao Z. | 01/8/2022 |
| High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma. | High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma.
Li S, Huang J, Yang F, Zeng H, Tong Y, Li K., Free PMC Article | 11/6/2021 |
| Par3 and ZO-1 Membrane Clustering is an Indicator of Poor Prognosis in Lung Squamous Cell Carcinoma. | Par3 and ZO-1 Membrane Clustering is an Indicator of Poor Prognosis in Lung Squamous Cell Carcinoma.
Nito M, Takekoshi S, Kitatani K, Matsuzaki T, Yagasaki H, Tsuboi T, Nakano K, Shioyama K, Masuda R, Iwazaki M. | 10/30/2021 |
| Loss of polarity protein Par3 is mediated by transcription factor Sp1 in breast cancer. | Loss of polarity protein Par3 is mediated by transcription factor Sp1 in breast cancer.
Zhao Y, Yao D, Li Y, Zhang S, Tao Z, Zhang L, Hu X, Wang B, Chen S. | 09/18/2021 |
| Loss of polarity protein Par3, via transcription factor Snail, promotes bladder cancer metastasis. | Loss of polarity protein Par3, via transcription factor Snail, promotes bladder cancer metastasis.
Wang S, Cai J, Zhang S, Dong M, Zhang L, Xu Y, Shen B, Chen S., Free PMC Article | 07/10/2021 |
| RAS-mediated suppression of PAR3 and its effects on SCC initiation and tissue architecture occur independently of hyperplasia. | RAS-mediated suppression of PAR3 and its effects on SCC initiation and tissue architecture occur independently of hyperplasia.
Ling J, Sckaff M, Tiwari M, Chen Y, Li J, Jones J, Sen GL., Free PMC Article | 07/10/2021 |
| Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death. | Adenoviral protein E4orf4 interacts with the polarity protein Par3 to induce nuclear rupture and tumor cell death.
Dziengelewski C, Rodrigue MA, Caillier A, Jacquet K, Boulanger MC, Bergeman J, Fuchs M, Lambert H, Laprise P, Richard DE, Bordeleau F, Huot MÉ, Lavoie JN., Free PMC Article | 01/2/2021 |
| The current study demonstrates that the SLCO4A1-AS1/miR-508-3p/PARD3/autophagy pathway play a critical role in colorectal cancer cell proliferatio | LncRNA SLCO4A1-AS1 promotes colorectal cancer cell proliferation by enhancing autophagy via miR-508-3p/PARD3 axis.
Wang Z, Jin J., Free PMC Article | 08/12/2020 |
| these findings identify RhoA as a novel target of Pard3 in gliomas and substantiate a novel regulatory role for Pard3 in glioma progression. | Pard3 suppresses glioma invasion by regulating RhoA through atypical protein kinase C/NF-κB signaling.
Li J, Xu H, Wang Q, Fu P, Huang T, Anas O, Zhao H, Xiong N., Free PMC Article | 07/4/2020 |
| The authors report here that the homophilic receptor PTPRK is stabilized at cell-cell contacts in epithelial cells. PTPRK directly and selectively dephosphorylates at least five substrates, including Afadin, PARD3 and delta-catenin family members, which are all important cell-cell adhesion regulators. | The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion.
Fearnley GW, Young KA, Edgar JR, Antrobus R, Hay IM, Liang WC, Martinez-Martin N, Lin W, Deane JE, Sharpe HJ., Free PMC Article | 03/21/2020 |
| PAR-3 controls microtubule stability via inhibition of GSK3beta in a dose-dependent manner. The dose-dependent effect of PAR-3 on GSK3beta phosphorylation is due to antagonism between the aPKC/PAR-3 and the aPKC/GSK3beta complexes. | PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow.
Hikita T, Mirzapourshafiyi F, Barbacena P, Riddell M, Pasha A, Li M, Kawamura T, Brandes RP, Hirose T, Ohno S, Gerhardt H, Matsuda M, Franco CA, Nakayama M., Free PMC Article | 06/8/2019 |
| Therefore, Porphyromonas gingivalis not only directly stimulates CXCL14 expression via PAR-3 but also promotes its expression by antagonising EGF signalling. | Interplay between Porphyromonas gingivalis and EGF signalling in the regulation of CXCL14.
Aw J, Scholz GM, Huq NL, Huynh J, O'Brien-Simpson NM, Reynolds EC. | 05/4/2019 |
| The expression of Pard3 was increased by the inhibition of miR-483, but TGF-beta1-induced cell migration and invasion were decreased by miR-483 inhibition. A dual-luciferase reporter assay determined that Pard3 expression was downregulated when targeted with miR-483. The epithelial-mesenchymal transition (EMT), as well as Tiam1-Rac signaling, was induced by TGF-beta1, which was decreased by the overexpression of Pard3. | MicroRNA 483-3p targets Pard3 to potentiate TGF-β1-induced cell migration, invasion, and epithelial-mesenchymal transition in anaplastic thyroid cancer cells.
Zhang X, Liu L, Deng X, Li D, Cai H, Ma Y, Jia C, Wu B, Fan Y, Lv Z., Free PMC Article | 03/2/2019 |
| Studies indicate that the PAR3-PAR6-aPKC complex are important for the establishment of neuronal polarity [Review]. | PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.
Hapak SM, Rothlin CV, Ghosh S. | 11/3/2018 |
| that this heterozygotic microdeletion showed no tissue specificity and led to defective expression of PARD3 | Quantitative Measurement of PARD3 Copy Number Variations in Human Neural Tube Defects.
Gao Y, Wang J, Shangguan S, Bao Y, Lu X, Zou J, Dai Y, Liu J, Zhang T. | 09/1/2018 |
| The authors identified a tumor-suppressive property function of Par3 in human cervical cancer and the lost Par3 expression may be a marker of poor prognosis. | Defective expression of polarity protein Par3 promotes cervical tumorigenesis and metastasis.
Zheng JH, Jiao SJ, Na L, Zheng SQ, Ma ZH, Wang SW, Aili A, Hasim A. | 08/4/2018 |
| We first demonstrate that Hook2 is essential for the polarized Golgi re-orientation towards the migration front. Depletion of Hook2 results in a decrease of PAR6alpha at the centrosome during cell migration, while overexpression of Hook2 in cells induced the formation of aggresomes with the recruitment of PAR6alpha, aPKC and PAR3 | Hook2, a microtubule-binding protein, interacts with Par6α and controls centrosome orientation during polarized cell migration.
Pallesi-Pocachard E, Bazellieres E, Viallat-Lieutaud A, Delgrossi MH, Barthelemy-Requin M, Le Bivic A, Massey-Harroche D., Free PMC Article | 06/2/2018 |
| elevated expression of Par3 promotes PCa metastasis via KIBRA sequestration-mediated inactivation of the Hippo pathway to upregulate expression of pro-metastatic genes. | Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway.
Zhou PJ, Xue W, Peng J, Wang Y, Wei L, Yang Z, Zhu HH, Fang YX, Gao WQ., Free PMC Article | 06/2/2018 |