| Drebrin is Required for Myosin-facilitated Actin Cytoskeletal Remodeling during Pulmonary Alveolar Development. | Drebrin is Required for Myosin-facilitated Actin Cytoskeletal Remodeling during Pulmonary Alveolar Development.
McGowan SE, Gilfanov N, Chandurkar MK, Stiber JA, Han SJ. | 04/8/2024 |
| A lack of drebrin causes olfactory impairment. | A lack of drebrin causes olfactory impairment.
Kajita Y, Kojima N, Shirao T., Free PMC Article | 03/27/2024 |
| Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons. | Drebrin Regulates Collateral Axon Branching in Cortical Layer II/III Somatosensory Neurons.
Dorskind JM, Sudarsanam S, Hand RA, Ziak J, Amoah-Dankwah M, Guzman-Clavel L, Soto-Vargas JL, Kolodkin AL., | 11/20/2023 |
| The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex. | The actin binding protein drebrin helps to protect against the development of seizure-like events in the entorhinal cortex.
Klemz A, Kreis P, Eickholt BJ, Gerevich Z., Free PMC Article | 11/13/2021 |
| Drebrin regulates cytoskeleton dynamics in migrating neurons through interaction with CXCR4. | Drebrin regulates cytoskeleton dynamics in migrating neurons through interaction with CXCR4.
Shan Y, Farmer SM, Wray S., Free PMC Article | 05/22/2021 |
| Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking. | Drebrin controls scar formation and astrocyte reactivity upon traumatic brain injury by regulating membrane trafficking.
Schiweck J, Murk K, Ledderose J, Münster-Wandowski A, Ornaghi M, Vida I, Eickholt BJ., Free PMC Article | 03/20/2021 |
| Drebrin is induced during myofibroblast differentiation and enhances the production of fibrosis-related genes. | Drebrin is induced during myofibroblast differentiation and enhances the production of fibrosis-related genes.
Hironaka T, Ueno T, Mae K, Yoshimura C, Morinaga T, Horii Y, Nagasaka A, Kurose H, Nakaya M. | 02/13/2021 |
| versus micropinocytosis activities. Taken together, these findings now reveal that Dbn1 plays a major role in coordinating the actin cytoskeletal activities responsible for antigen presentation in DC. | Drebrin 1 in dendritic cells regulates phagocytosis and cell surface receptor expression through recycling for efficient antigen presentation.
Elizondo DM, Andargie TE, Haddock NL, Boddie TA, Lipscomb MW., Free PMC Article | 08/10/2019 |
| neuronal drebrin A directly interacts with mDia2 formin. | Neuronal drebrin A directly interacts with mDia2 formin to inhibit actin assembly.
Ginosyan AA, Grintsevich EE, Reisler E., Free PMC Article | 06/29/2019 |
| An excess of reactive oxygen species stimulates ATM-dependent phosphorylation of DBN at serine-647, which enhances protein stability and accounts for improved stress resilience in dendritic spines. | ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ., Free PMC Article | 04/20/2019 |
| Functional perturbations of drebrin demonstrate that proximal leading process microtubule-actomyosin coupling steers the direction of centrosome and somal migration, as well as the switch from tangential to radial migration. | Drebrin-mediated microtubule-actomyosin coupling steers cerebellar granule neuron nucleokinesis and migration pathway selection.
Trivedi N, Stabley DR, Cain B, Howell D, Laumonnerie C, Ramahi JS, Temirov J, Kerekes RA, Gordon-Weeks PR, Solecki DJ., Free PMC Article | 11/10/2018 |
| Hippocampal Drebrin protein expression levels in adult APP/PS1 mice decline with age. Behavioral data demonstrated that cognitive and probe activities decline with age. A correlation analysis showed that the expression level of the Drebrin protein significantly correlatives with behavioral performance in Alzheimer's disease mice. | Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice.
Liu Y, Xu YF, Zhang L, Huang L, Yu P, Zhu H, Deng W, Qin C., Free PMC Article | 07/21/2018 |
| In subventricular zone of Dbn1-null mice number of neuroblasts and cell proliferation decreased, although cell death remained unchanged. | Drebrin E regulates neuroblast proliferation and chain migration in the adult brain.
Kajita Y, Kojima N, Koganezawa N, Yamazaki H, Sakimura K, Shirao T. | 05/26/2018 |
| Inhibition of cortactin or dynamin-2 abrogated the increased virus entry observed in DBN1-deficient cells, suggesting that DBN1 suppresses dynamin-mediated endocytosis via interaction with cortactin. | Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.
Li B, Ding S, Feng N, Mooney N, Ooi YS, Ren L, Diep J, Kelly MR, Yasukawa LL, Patton JT, Yamazaki H, Shirao T, Jackson PK, Greenberg HB., Free PMC Article | 04/28/2018 |
| these findings suggest that during cell migration drebrin is involved in retraction processes but not in lamellipodia formation. The novel, sizable juxtanuclear drebrin-enriched zone remains to be characterized in detail with respect to its molecular assembly and functions. | Juxtanuclear Drebrin-Enriched Zone.
Ludwig-Peitsch WK. | 12/2/2017 |
| Drebrin A can be found co-clustering with NR2B-containing NMDARs at the plasma membrane, while NR2A-containing NMDARs co-traffic into the spine cytoplasm but do not co-cluster at the plasma membrane. | Making of a Synapse: Recurrent Roles of Drebrin A at Excitatory Synapses Throughout Life.
Aoki C, Sherpa AD. | 12/2/2017 |
| Drebrin A is highly enriched in dendritic spines, but its effects on actin morphology, dynamics, and interplay with other actin regulators are yet to be clarified. Here we review recent advances in understanding drebrin effects on actin morphology and dynamics. | Remodeling of Actin Filaments by Drebrin A and Its Implications.
Grintsevich EE. | 12/2/2017 |
| bn1 expression is induced during myoblast differentiation, in a p38 MAP kinase- and MyoD- dependent manner. RNAi-mediated depletion of drebrin, or treatment with a chemical drebrin inhibitor, resulted in a similar phenotype in myoblasts: defective differentiation, with low levels of early and late differentiation markers and inefficient production of myofibers. | Regulation of Skeletal Myoblast Differentiation by Drebrin.
Krauss RS. | 12/2/2017 |
| Study determines the specific roles of drebrin in the regulation of the axonal cytoskeleton, and provides evidence that drebrin contributes to the coordination of the actin and microtubule cytoskeleton during the initial stages of axon branching. | Drebrin coordinates the actin and microtubule cytoskeleton during the initiation of axon collateral branches.
Ketschek A, Spillane M, Dun XP, Hardy H, Chilton J, Gallo G., Free PMC Article | 09/30/2017 |
| Drebrin reduces SMC activation through its interaction with the actin cytoskeleton but independently of its interaction with Homer scaffolds to prevent neointima formation. | The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia.
Stiber JA, Wu JH, Zhang L, Nepliouev I, Zhang ZS, Bryson VG, Brian L, Bentley RC, Gordon-Weeks PR, Rosenberg PB, Freedman NJ., Free PMC Article | 06/24/2017 |
| Data suggest further studies to elucidate the effect of drebrin (Dbn) on the development and progression of Alzheimer's disease (AD). | Down-Regulated Drebrin Aggravates Cognitive Impairments in a Mouse Model of Alzheimer's Disease.
Liu Y, Xu Y, Zhang L, Huang L, Yu P, Zhu H, Deng W, Qin C., Free PMC Article | 06/3/2017 |
| Study demonstrated that isoform conversion of drebrin is critical, and that drebrin A is indispensable for adult hippocampal synaptic plasticity and hippocampus-dependent fear learning; the phenotype of drebrin A knockout mice suggests functional differences between drebrin A and drebrin E | Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice.
Kojima N, Yasuda H, Hanamura K, Ishizuka Y, Sekino Y, Shirao T. | 01/14/2017 |
| These findings provide unprecedented experimental support for a role of drebrin in the regulation of memory-related synaptic plasticity and neurotransmitter receptor signaling | Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus.
Jung G, Kim EJ, Cicvaric A, Sase S, Gröger M, Höger H, Sialana FJ, Berger J, Monje FJ, Lubec G. | 09/26/2015 |
| Dbn1 regulates systemic anaphylaxis and IgE/Fcgr1-induced degranulation in mast cells by regulating actin reorganization and actin dynamics. | Cutting Edge: Drebrin-Regulated Actin Dynamics Regulate IgE-Dependent Mast Cell Activation and Allergic Responses.
Law M, Lee Y, Morales JL, Ning G, Huang W, Pabon J, Kannan AK, Jeong AR, Wood A, Carter C, Mohinta S, Song J, August A., Free PMC Article | 09/12/2015 |
| SAHA likely inhibits ADDL-induced drebrin loss from dendritic spines by stabilizing drebrin in these structures, rather than by increasing drebrin clusters or dendritic protrusions | Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers.
Ishizuka Y, Shimizu H, Takagi E, Kato M, Yamagata H, Mikuni M, Shirao T. | 05/16/2015 |