| regulator of nucleosomal remodelling in the diabetic milieu | miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.
Badal SS, Wang Y, Long J, Corcoran DL, Chang BH, Truong LD, Kanwar YS, Overbeek PA, Danesh FR., Free PMC Article | 08/25/2018 |
| chromatin modifier, MSK1/2, has a role in suppressing endocrine and promoting acinar differentiation during pancreatic development | The Chromatin Modifier MSK1/2 Suppresses Endocrine Cell Fates during Mouse Pancreatic Development.
Bhat N, Park J, Zoghbi HY, Arthur JS, Zaret KS., Free PMC Article | 07/15/2017 |
| Accelerated apoptotic death and in vivo turnover of erythrocytes have been found in mice lacking functional MSK1/MSK2. | Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2.
Lang E, Bissinger R, Fajol A, Salker MS, Singh Y, Zelenak C, Ghashghaeinia M, Gu S, Jilani K, Lupescu A, Reyskens KM, Ackermann TF, Föller M, Schleicher E, Sheffield WP, Arthur JS, Lang F, Qadri SM., Free PMC Article | 09/24/2016 |
| Results suggest that MSK1/2 plays a significant role in the regulation of ischemia-induced progenitor cell proliferation and neurogenesis | Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis.
Karelina K, Liu Y, Alzate-Correa D, Wheaton KL, Hoyt KR, Arthur JS, Obrietan K., Free PMC Article | 01/2/2016 |
| MSK1/2 knockout results in reduced IL-10 secretion. | MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop.
MacKenzie KF, Van Den Bosch MW, Naqvi S, Elcombe SE, McGuire VA, Reith AD, Blackshear PJ, Dean JL, Arthur JS., Free PMC Article | 08/3/2013 |
| data reveal a critical role for MSK1/2 as regulators of both basal and activity-dependent progenitor cell proliferation and morphological maturation in the subgranular zone | Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.
Choi YS, Karelina K, Alzate-Correa D, Hoyt KR, Impey S, Arthur JS, Obrietan K., Free PMC Article | 01/12/2013 |
| Comparison of the effects of SB-747651A, both in vitro and in cells, demonstrated that SB-747651A exhibited improved selectivity over H89 and Ro 31-8220 and therefore represents a useful tool to study MSK function in cells. | Characterization of the cellular action of the MSK inhibitor SB-747651A.
Naqvi S, Macdonald A, McCoy CE, Darragh J, Reith AD, Arthur JS. | 02/18/2012 |
| MSK1/2 are involved in the activation of feedback mechanisms that dampen oxazolone-induced skin inflammation. | The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice.
Bertelsen T, Iversen L, Riis JL, Arthur JS, Bibby BM, Kragballe K, Johansen C. | 06/25/2011 |
| These data provide in vivo evidence that MSK1/2 signaling represents a novel tumor-promoting axis in skin carcinogenesis. | Mice lacking MSK1 and MSK2 show reduced skin tumor development in a two-stage chemical carcinogenesis model.
Chang S, Iversen L, Kragballe K, Arthur JS, Johansen C. | 04/2/2011 |
| MSK1/2 regulate pri-miR-212/132 transcription via the phosphorylation of CREB. | Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins.
Remenyi J, Hunter CJ, Cole C, Ando H, Impey S, Monk CE, Martin KJ, Barton GJ, Hutvagner G, Arthur JS. | 05/31/2010 |
| correlated to a reduction in the T-Cell Receptor-induced up-regulation of the IL-2 receptor CD25 and a requirement for MSK in IL-2-induced CREB phosphorylation | MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription.
Kaiser M, Wiggin GR, Lightfoot K, Arthur JS, Macdonald A. | 01/21/2010 |
| MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. | MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS., Free PMC Article | 01/21/2010 |
| findings suggested that MSK1/2 might play a critical role in the survival of lipopolysaccharide-stimulated RAW 264.7 cells | A role of mitogen and stress-activated protein kinase 1/2 in survival of lipopolysaccharide-stimulated RAW 264.7 macrophages.
Mu MM, Koide N, Hassan F, Islam S, Sugiyama T, Ito H, Mori I, Yoshida T, Yokochi T. | 01/21/2010 |
| MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation | The kinases MSK1 and MSK2 are required for epidermal growth factor-induced, but not tumor necrosis factor-induced, histone H3 Ser10 phosphorylation.
Duncan EA, Anest V, Cogswell P, Baldwin AS. | 01/21/2010 |