| The intestinal commensal fungus Wallemia mellicola enhances asthma in mice through Dectin-2. | The intestinal commensal fungus Wallemia mellicola enhances asthma in mice through Dectin-2.
Kanj AN, Guiance IR, Kottom TJ, Schaefbauer KJ, Choudhury M, Limper AH, Skalski JH., | 02/29/2024 |
| Dectin-2 Deficiency Promotes Proinflammatory Cytokine Release From Macrophages and Impairs Insulin Secretion. | Dectin-2 Deficiency Promotes Proinflammatory Cytokine Release From Macrophages and Impairs Insulin Secretion.
Fujita M, Miyazawa T, Uchida K, Uchida N, Haji S, Yano S, Iwahashi N, Hatayama T, Katsuhara S, Nakamura S, Takeichi Y, Yokomoto-Umakoshi M, Miyachi Y, Sakamoto R, Iwakura Y, Ogawa Y. | 01/3/2024 |
| Dectin-2 is critical for phagocyte function and resistance to Paracoccidioides brasiliensis in mice. | Dectin-2 is critical for phagocyte function and resistance to Paracoccidioides brasiliensis in mice.
Cardoso-Miguel MRD, Bürgel PH, de Castro RJA, Marina CL, de Oliveira SA, Albuquerque P, Silva-Pereira I, Bocca AL, Tavares AH. | 11/30/2023 |
| The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan. | The C-Type Lectin Receptor Dectin-2 Is a Receptor for Aspergillus fumigatus Galactomannan.
Reedy JL, Crossen AJ, Negoro PE, Harding HB, Ward RA, Vargas-Blanco DA, Timmer KD, Reardon CM, Basham KJ, Mansour MK, Wüthrich M, Fontaine T, Latgé JP, Vyas JM., Free PMC Article | 03/2/2023 |
| Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice. | Deletion of both Dectin-1 and Dectin-2 affects the bacterial but not fungal gut microbiota and susceptibility to colitis in mice.
Wang Y, Spatz M, Da Costa G, Michaudel C, Lapiere A, Danne C, Agus A, Michel ML, Netea MG, Langella P, Sokol H, Richard ML., Free PMC Article | 06/18/2022 |
| Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin. | Dectin-2-mediated initiation of immune responses caused by influenza virus hemagglutinin.
Yamamoto H, Tomiyama C, Sato K, Kasamatsu J, Takano K, Umeki A, Nakahata N, Miyasaka T, Kanno E, Tanno H, Yamasaki S, Saijo S, Iwakura Y, Ishii K, Kawakami K. | 12/25/2021 |
| Dectin-2 mediates phagocytosis of Lactobacillus paracasei KW3110 and IL-10 production by macrophages. | Dectin-2 mediates phagocytosis of Lactobacillus paracasei KW3110 and IL-10 production by macrophages.
Yoshikawa M, Yamada S, Sugamata M, Kanauchi O, Morita Y., Free PMC Article | 11/13/2021 |
| CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection. | CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection.
Campuzano A, Zhang H, Ostroff GR, Dos Santos Dias L, Wüthrich M, Klein BS, Yu JJ, Lara HH, Lopez-Ribot JL, Hung CY., Free PMC Article | 02/13/2021 |
| Association of modulation of pro-inflammatory responses by dectin-2 with preterm delivery: An experimental model. | Association of modulation of pro-inflammatory responses by dectin-2 with preterm delivery: An experimental model.
Liassidou A, Renieris G, Droggiti DI, Gkavogianni T, Liassides C, Sabracos L, Giamarellos-Bourboulis EJ, Siristatidis CS. | 01/23/2021 |
| Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice. | Deletion of hematopoietic Dectin-2 or CARD9 does not protect against atherosclerotic plaque formation in hyperlipidemic mice.
Thiem K, Hoeke G, van den Berg S, Hijmans A, Jacobs CWM, Zhou E, Mol IM, Mouktaroudi M, Bussink J, Kanneganti TD, Lutgens E, Stienstra R, Tack CJ, Netea MG, Rensen PCN, Berbée JFP, van Diepen JA., Free PMC Article | 10/24/2020 |
| deficiency in FcRgamma itself or two receptors to which it couples (dectin-2 and mincle) impacts phagocytosis of six fungal organisms | The pattern recognition receptors dectin-2, mincle, and FcRγ impact the dynamics of phagocytosis of Candida, Saccharomyces, Malassezia, and Mucor species.
Haider M, Dambuza IM, Asamaphan P, Stappers M, Reid D, Yamasaki S, Brown GD, Gow NAR, Erwig LP., Free PMC Article | 03/21/2020 |
| The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. | The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.
Thompson A, Davies LC, Liao CT, da Fonseca DM, Griffiths JS, Andrews R, Jones AV, Clement M, Brown GD, Humphreys IR, Taylor PR, Orr SJ., Free PMC Article | 12/7/2019 |
| Dectin-1/Dectin-2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses. | Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.
Kaisar MMM, Ritter M, Del Fresno C, Jónasdóttir HS, van der Ham AJ, Pelgrom LR, Schramm G, Layland LE, Sancho D, Prazeres da Costa C, Giera M, Yazdanbakhsh M, Everts B., Free PMC Article | 03/30/2019 |
| mDectin-1, mDectin-2, and SIGN-R1 are decorated by N-glycan structures that can be recognized by the carbohydrate recognition domain of Gal-3. | Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins.
Leclaire C, Lecointe K, Gunning PA, Tribolo S, Kavanaugh DW, Wittmann A, Latousakis D, MacKenzie DA, Kawasaki N, Juge N., Free PMC Article | 01/19/2019 |
| Dectin-2 is a primary factor in activation of NLRP3 inflammasome during Histoplasma capsulatum infection. | Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum.
Chang TH, Huang JH, Lin HC, Chen WY, Lee YH, Hsu LC, Netea MG, Ting JP, Wu-Hsieh BA., Free PMC Article | 12/23/2017 |
| this report relates the potential of the Dectin-2/Card9-coupled pathway in ocular autoimmunity. Not only does it contribute to understanding of how innate immune receptors orchestrate T cell-mediated autoimmunity, it also reveals a previously unappreciated ability of fungal-derived signals to promote autoimmunity. | Fungal-derived cues promote ocular autoimmunity through a Dectin-2/Card9-mediated mechanism.
Brown BR, Lee EJ, Snow PE, Vance EE, Iwakura Y, Ohno N, Miura N, Lin X, Brown GD, Wells CA, Smith JR, Caspi RR, Rosenzweig HL., Free PMC Article | 11/26/2017 |
| a glycosylated protein with mannose-related structure is recognized by Dectin-2 in dendritic cells | C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein β-Glucuronidase on Dendritic Cells.
Mori D, Shibata K, Yamasaki S., Free PMC Article | 08/26/2017 |
| Dectin-2 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores. | Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1.
Walsh NM, Wuthrich M, Wang H, Klein B, Hull CM., Free PMC Article | 08/19/2017 |
| activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk-dependent manner. | E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity.
Zhu LL, Luo TM, Xu X, Guo YH, Zhao XQ, Wang TT, Tang B, Jiang YY, Xu JF, Lin X, Jia XM., Free PMC Article | 07/29/2017 |
| this study shows that in vitro, cytokine production by bone marrow-derived dendritic cells is dependent on dectin-2; in vivo, its deficiency compromises fungal clearance | Dectin-1 and Dectin-2 promote control of the fungal pathogen Trichophyton rubrum independently of IL-17 and adaptive immunity in experimental deep dermatophytosis.
Yoshikawa FS, Yabe R, Iwakura Y, de Almeida SR, Saijo S. | 07/1/2017 |
| these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 responses through interaction with Dectin-2. | Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells.
Wittmann A, Lamprinaki D, Bowles KM, Katzenellenbogen E, Knirel YA, Whitfield C, Nishimura T, Matsumoto N, Yamamoto K, Iwakura Y, Saijo S, Kawasaki N., Free PMC Article | 05/13/2017 |
| Dectin-2 leads to an increase in cardiac rupture, impairs wound healing, and aggravates cardiac remodeling after MI through the modulation of Th1 differentiation. | Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.
Yan X, Zhang H, Fan Q, Hu J, Tao R, Chen Q, Iwakura Y, Shen W, Lu L, Zhang Q, Zhang R. | 05/7/2017 |
| this study demonstrates the role of Dectin-2 as an essential trigger of host defense in a murine model of systemic candidiasis | The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis.
Ifrim DC, Quintin J, Courjol F, Verschueren I, van Krieken JH, Koentgen F, Fradin C, Gow NA, Joosten LA, van der Meer JW, van de Veerdonk F, Netea MG., Free PMC Article | 12/24/2016 |
| Polymorphisms within the NKC modulate malarial pathogenesis and acquired immune responses to infection. | The contribution of natural killer complex loci to the development of experimental cerebral malaria.
Hansen DS, Ryg-Cornejo V, Ioannidis LJ, Chiu CY, Ly A, Nie CQ, Scalzo AA, Schofield L., Free PMC Article | 12/19/2015 |
| The results indicate differential roles for Dectin-2 and Mincle in the generation of adaptive immune responses to F. pedrosoi fungal infection in mice. | Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition.
Wüthrich M, Wang H, Li M, Lerksuthirat T, Hardison SE, Brown GD, Klein B., Free PMC Article | 11/28/2015 |