| Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes. | Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes.
Wong J, Damdimopoulos A, Damdimopoulou P, Gasperoni JG, Tran SC, Grommen SVH, De Groef B, Dworkin S. | 11/6/2021 |
| Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis. | Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis.
Wong J, Juma AR, Tran SC, Gasperoni JG, Grommen SVH, De Groef B., Free PMC Article | 06/26/2021 |
| Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice. | Effect of Pleomorphic Adenoma Gene 1 Deficiency on Selected Behaviours in Adult Mice.
Tran SC, Jaehne EJ, Dye LE, Wong J, Bakas JS, Gasperoni JG, Hale MW, van den Buuse M, Dworkin S, Grommen SVH, De Groef B. | 05/15/2021 |
| Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development. | Pleomorphic Adenoma Gene 1 Is Needed For Timely Zygotic Genome Activation and Early Embryo Development.
Madissoon E, Damdimopoulos A, Katayama S, Krjutškov K, Einarsdottir E, Mamia K, De Groef B, Hovatta O, Kere J, Damdimopoulou P., Free PMC Article | 10/24/2020 |
| lncRNAs and mRNAs were differentially expressed in pleomorphic adenoma tissues obtained from PLAG1 transgenic mice as compared with those from control mice. These differentially expressed lncRNAs may act as novel biomarkers and therapeutic targets for pleomorphic adenoma. | Dysregulated long non‑coding RNAs in pleomorphic adenoma tissues of pleomorphic adenoma gene 1 transgenic mice.
Xu W, Liu L, Lu H, Fu J, Zhang C, Yang W, Shen S., Free PMC Article | 09/14/2019 |
| PLAG1 deficiency does not have a major impact on the reproductive control by the hypothalamo-pituitary system. | PLAG1 expression and target genes in the hypothalamo-pituitary system in male mice.
Juma AR, Hall NE, Wong J, Gasperoni JG, Watanabe Y, Sahota A, Damdimopoulou PE, Grommen SVH, De Groef B. | 05/11/2019 |
| Loss of PLAG1 resulted in significantly lowered daily sperm production, in reduced sperm motility, and in several animals, in sloughing of the germinal epithelium. The results demonstrate that the subfertility seen in male PLAG1-deficient mice is, at least in part, the result of significantly reduced sperm output and sperm motility. | PLAG1 deficiency impairs spermatogenesis and sperm motility in mice.
Juma AR, Grommen SVH, O'Bryan MK, O'Connor AE, Merriner DJ, Hall NE, Doyle SR, Damdimopoulou PE, Barriga D, Hart AH, Van de Ven WJM, De Groef B., Free PMC Article | 01/19/2019 |
| Forced expression of PLAG1 under the control of the Pdx1 or Ngn3 promoter in murine pancreas induces different degrees of endocrine hormone imbalances. | Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism.
Declercq J, Kumar A, Gysemans C, Di Pietro C, Schraenen A, Chintinne M, Lemaire K, Van Lommel L, Van De Casteele M, Heimberg H, Pipeleers D, Schuit FC, Mathieu C, Ectors N, Van de Ven WJ, Verfaillie CM. | 03/10/2012 |
| Data indicate a plausible Plag1-Egr1-CD44 regulatory pathway in the T-ICs of pleomorphic adenomas. | Tumor-initiating cells are enriched in CD44(hi) population in murine salivary gland tumor.
Shen S, Yang W, Wang Z, Lei X, Xu L, Wang Y, Wang L, Huang L, Yu Z, Zhang X, Li J, Chen Y, Zhao X, Yin X, Zhang C., Free PMC Article | 02/18/2012 |
| results establish the oncogenic potential of PLAG1 in mammary glands of mice and point towards contributing roles of Igf and Wnt signaling | Adenomyoepitheliomatous lesions of the mammary glands in transgenic mice with targeted PLAG1 overexpression.
Declercq J, Skaland I, Van Dyck F, Janssen EA, Baak JP, Drijkoningen M, Van de Ven WJ. | 01/21/2010 |
| Suggest an important role for furin in PLAG1-induced salivary gland tumorigenesis in mice. | MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice.
De Vos L, Declercq J, Rosas GG, Van Damme B, Roebroek A, Vermorken F, Ceuppens J, van de Ven W, Creemers J. | 01/21/2010 |
| Demonstrate upregulation of several genes associated with Igf and Wnt signalling in PLAG1-induced pleomorphic adenomas. Inactivation of Igf2 delays tumour development. | Upregulation of Igf and Wnt signalling associated genes in pleomorphic adenomas of the salivary glands in PLAG1 transgenic mice.
Declercq J, Van Dyck F, Van Damme B, Van de Ven WJ. | 01/21/2010 |
| aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice. | aP2-Cre-mediated expression activation of an oncogenic PLAG1 transgene results in cavernous angiomatosis in mice.
Van Dyck F, Scroyen I, Declercq J, Sciot R, Kahn B, Lijnen R, Van de Ven WJ. | 01/21/2010 |
| Plag1 disruption in mouse differentially affects pre- and postnatal growth and development of organs, with reproductive repercussions | Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility.
Hensen K, Braem C, Declercq J, Van Dyck F, Dewerchin M, Fiette L, Denef C, Van de Ven WJ. | 01/21/2010 |