| CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF-beta1/Smad2/3 signaling in mouse viral myocarditis. | CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF-β1/Smad2/3 signaling in mouse viral myocarditis.
Wei J, Wang DF, Cui CC, Tan JJ, Peng MY, Lu HX., Free PMC Article | 04/8/2024 |
| Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. | Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury.
Ngo AT, Skidmore A, Oberg J, Yarovoi I, Sarkar A, Levine N, Bochenek V, Zhao G, Rauova L, Kowalska MA, Eckart K, Mangalmurti NS, Rux A, Cines DB, Poncz M, Gollomp K., Free PMC Article | 03/13/2024 |
| Inhibition of cellular activation induced by platelet factor 4 via the CXCR3 pathway ameliorates Japanese encephalitis and dengue viral infections. | Inhibition of cellular activation induced by platelet factor 4 via the CXCR3 pathway ameliorates Japanese encephalitis and dengue viral infections.
Singh A, Ghosh R, Asuru TR, Prajapat SK, Joshi G, Gaur KK, Shrimali NM, Ojha A, Vikram NK, Poncz M, Kalia M, Guchhait P. | 03/1/2024 |
| Platelet factor 4 induces bone loss by inhibiting the integrin alpha5-FAK-ERK pathway. | Platelet factor 4 induces bone loss by inhibiting the integrin α5-FAK-ERK pathway.
Li W, Zhang Q, Gu R, Zeng L, Liu H., Free PMC Article | 01/12/2024 |
| Platelet factors attenuate inflammation and rescue cognition in ageing. | Platelet factors attenuate inflammation and rescue cognition in ageing.
Schroer AB, Ventura PB, Sucharov J, Misra R, Chui MKK, Bieri G, Horowitz AM, Smith LK, Encabo K, Tenggara I, Couthouis J, Gross JD, Chan JM, Luke A, Villeda SA., Free PMC Article | 09/14/2023 |
| Chemokine PF4 Inhibits EV71 and CA16 Infections at the Entry Stage. | Chemokine PF4 Inhibits EV71 and CA16 Infections at the Entry Stage.
Pei Z, Wang H, Zhao Z, Chen X, Huan C, Zhang W., Free PMC Article | 06/18/2022 |
| SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway. | SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway.
Zeng B, Sun Z, Zhao Q, Liu D, Chen H, Li X, Xing HR, Wang J., Free PMC Article | 03/19/2022 |
| Platelet factor 4 is a biomarker for lymphatic-promoted disorders. | Platelet factor 4 is a biomarker for lymphatic-promoted disorders.
Ma W, Gil HJ, Escobedo N, Benito-Martín A, Ximénez-Embún P, Muñoz J, Peinado H, Rockson SG, Oliver G., Free PMC Article | 06/12/2021 |
| CXCL4 promoted the production of CD4(+)CD25(+)FOXP3(+)treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway. | CXCL4 promoted the production of CD4(+)CD25(+)FOXP3(+)treg cells in mouse sepsis model through regulating STAT5/FOXP3 pathway.
Xu T, Zhao J, Wang X, Meng Y, Zhao Z, Bao R, Deng X, Bian J, Yang T. | 06/5/2021 |
| ELF4 binds to the promoter of genes of two C-X-C chemokines, Pf4 and pro-platelet basic protein (Ppbp), initiating the transcription of these two genes, thereby enhancing PF4-mediated killing of parasites from infected erythrocytes. | ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp.
Wang D, Zhang Z, Cui S, Zhao Y, Craft S, Fikrig E, You F., Free PMC Article | 12/14/2019 |
| Platelets are activated during P. aeruginosa infection, and mice depleted of platelets display markedly increased mortality and impaired bacterial clearance. CXCL4 deficiency impairs bacterial clearance and lung epithelial permeability. CXCL4 deficiency selectively regulates chemokine production. CXCL4 deficiency reduces platelet-neutrophil interactions in blood following P. aeruginosa infection. | CXCL4 contributes to host defense against acute Pseudomonas aeruginosa lung infection.
Yue L, Pang Z, Li H, Yang T, Guo L, Liu L, Mei J, Song X, Xie T, Zhang Y, He X, Lin TJ, Xie Z., Free PMC Article | 04/6/2019 |
| these data demonstrate that PF4 has an important role in increasing B cell differentiation in the bone marrow environment | Platelet factor 4 increases bone marrow B cell development and differentiation.
Field DJ, Aggrey-Amable AA, Blick SK, Ture SK, Johanson A, Cameron SJ, Roy S, Morrell CN., Free PMC Article | 07/7/2018 |
| these results identify CXCL4 as a vital immunoregulatory chemokine essential for protecting mice against influenza A virus infection, especially as it affects the development of lung injury and neutrophil mobilization to the inflamed lung | Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection.
Guo L, Feng K, Wang YC, Mei JJ, Ning RT, Zheng HW, Wang JJ, Worthen GS, Wang X, Song J, Li QH, Liu LD. | 06/2/2018 |
| These results indicate that CXCL4 is a novel Ni-binding protein that augments Ni allergy at the elicitation and sensitization phases. This is the first study to demonstrate that the Ni-binding protein augments Ni allergy in vivo. | CXCL4 is a novel nickel-binding protein and augments nickel allergy.
Kuroishi T, Bando K, Tanaka Y, Shishido K, Kinbara M, Ogawa T, Muramoto K, Endo Y, Sugawara S. | 04/21/2018 |
| PF4 was produced by Ly6G+CD11b+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression. | Platelet factor 4 is produced by subsets of myeloid cells in premetastatic lung and inhibits tumor metastasis.
Jian J, Pang Y, Yan HH, Min Y, Achyut BR, Hollander MC, Lin PC, Liang X, Yang L., Free PMC Article | 04/7/2018 |
| These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal. | CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.
Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LE, Kinstrie R, Guitart AV, Dunn K, Abraham SA, Sansom O, Michie AM, Machesky L, Kranc KR, Graham GJ, Pellicano F, Holyoake TL., Free PMC Article | 08/5/2017 |
| Platelet-derived CXCL7 and CXCL4 contribute to the pathogenesis of acute lung injury. | Platelet-Specific Chemokines Contribute to the Pathogenesis of Acute Lung Injury.
Bdeir K, Gollomp K, Stasiak M, Mei J, Papiewska-Pajak I, Zhao G, Worthen GS, Cines DB, Poncz M, Kowalska MA., Free PMC Article | 07/1/2017 |
| CXCL4 plays an important role in pancreatic inflammation | Platelet-derived CXCL4 regulates neutrophil infiltration and tissue damage in severe acute pancreatitis.
Wetterholm E, Linders J, Merza M, Regner S, Thorlacius H. | 07/1/2017 |
| Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage | Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage.
Hwaiz R, Rahman M, Zhang E, Thorlacius H., Free PMC Article | 10/29/2016 |
| PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins. | Intramedullary megakaryocytes internalize released platelet factor 4 and store it in alpha granules.
Lambert MP, Meng R, Xiao L, Harper DC, Marks MS, Kowalska MA, Poncz M., Free PMC Article | 08/6/2016 |
| Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes. | Heparin enhances uptake of platelet factor 4/heparin complexes by monocytes and macrophages.
Joglekar M, Khandelwal S, Cines DB, Poncz M, Rauova L, Arepally GM., Free PMC Article | 06/11/2016 |
| Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation. | Platelet factor 4 limits Th17 differentiation and ischaemia-reperfusion injury after liver transplantation in mice.
Guo H, Wang Y, Zhao Z, Shao X. | 04/25/2015 |
| CXCL4 regulates hematopoietic stem cell cell cycle activity. | Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Bruns I, Lucas D, Pinho S, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS., Free PMC Article | 01/24/2015 |
| Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection | Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection.
Shi G, Field DJ, Ko KA, Ture S, Srivastava K, Levy S, Kowalska MA, Poncz M, Fowell DJ, Morrell CN., Free PMC Article | 04/12/2014 |
| Histones regulate activated protein C formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis. | Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation.
Kowalska MA, Zhao G, Zhai L, David G 3rd, Marcus S, Krishnaswamy S, Poncz M. | 02/22/2014 |