| Maternal exposure to atmospheric PM2.5 and fetal brain development: Associations with BAI1 methylation and thyroid hormones. | Maternal exposure to atmospheric PM(2.5) and fetal brain development: Associations with BAI1 methylation and thyroid hormones.
Zeng Z, Xu X, Wang Q, Zhang Z, Meng P, Huo X. | 07/30/2022 |
| BAI1 nuclear expression reflects the survival of nonsmoking non-small cell lung cancer patients. | BAI1 nuclear expression reflects the survival of nonsmoking non-small cell lung cancer patients.
An HJ, Kim SH, Yang JW, Kim MH, Baek HJ, Ryu KH, Jeon KN, Lee CS, Choi JY, Song DH., Free PMC Article | 01/8/2022 |
| BAI1 as a Prognostic Marker of Clear Cell Renal Cell Carcinoma (ccRCC). | BAI1 as a Prognostic Marker of Clear Cell Renal Cell Carcinoma (ccRCC).
Pesta M, Travnicek I, Kulda V, Windrichova J, Rezackova H, Houfkova K, Macanova T, Bendova B, Nestorova A, Hes O, Hora M, Topolcan O, Polivka J. | 09/11/2021 |
| BAI1 acts as a tumor suppressor in lung cancer A549 cells by inducing metabolic reprogramming via the SCD1/HMGCR module. | BAI1 acts as a tumor suppressor in lung cancer A549 cells by inducing metabolic reprogramming via the SCD1/HMGCR module.
Liu L, Chai L, Ran J, Yang Y, Zhang L. | 05/22/2021 |
| EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway. | EZH2 targeting reduces medulloblastoma growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway.
Zhang H, Zhu D, Zhang Z, Kaluz S, Yu B, Devi NS, Olson JJ, Van Meir EG., Free PMC Article | 11/28/2020 |
| Brain-specific angiogenesis inhibitor 1 is expressed in the Myo/Nog cell lineage. | Brain-specific angiogenesis inhibitor 1 is expressed in the Myo/Nog cell lineage.
Gerhart J, Bowers J, Gugerty L, Gerhart C, Martin M, Abdalla F, Bravo-Nuevo A, Sullivan JT, Rimkunas R, Albertus A, Casta L, Getts L, Getts R, George-Weinstein M., Free PMC Article | 09/12/2020 |
| Brain-specific angiogenesis inhibitor 1 (BAI1) prevents proto-oncogene Protein c-mdm2 (Mdm2)-mediated tumor supressor p53 (p53) polyubiquitination, and its loss substantially reduces p53 levels. | BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.
Zhu D, Osuka S, Zhang Z, Reichert ZR, Yang L, Kanemura Y, Jiang Y, You S, Zhang H, Devi NS, Bhattacharya D, Takano S, Gillespie GY, Macdonald T, Tan C, Nishikawa R, Nelson WG, Olson JJ, Van Meir EG., Free PMC Article | 05/25/2019 |
| We have uncovered a new role for BAI1 in facilitating macrophage anti-viral responses. We show that arming oHSV with antiangiogenic Vstat120 also shields them from inflammatory macrophage antiviral response, without reducing safety | BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy.
Bolyard C, Meisen WH, Banasavadi-Siddegowda Y, Hardcastle J, Yoo JY, Wohleb ES, Wojton J, Yu JG, Dubin S, Khosla M, Xu B, Smith J, Alvarez-Breckenridge C, Pow-Anpongkul P, Pichiorri F, Zhang J, Old M, Zhu D, Van Meir EG, Godbout JP, Caligiuri MA, Yu J, Kaur B., Free PMC Article | 02/10/2018 |
| Data suggest agonist-induced signal transduction via either BAI1/ADGRB1 or GPR56/ADGRG1 does not require conserved membrane-proximal stalk region; thus, it appears GAIN domain cleavage via autoproteolysis is not necessary for receptor activation. | Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1).
Kishore A, Purcell RH, Nassiri-Toosi Z, Hall RA., Free PMC Article | 07/16/2016 |
| BAI1 may be involved in the negative regulation of bladder transitional cell carcinoma microvascular proliferation, and its expression may be associated with a reduction in p53 mutations. | Expression of brain‑specific angiogenesis inhibitor‑1 and association with p53, microvessel density and vascular endothelial growth factor in the tissue of human bladder transitional cell carcinoma.
Tian D, Hu H, Sun Y, Tang Y, Lei M, Liu L, Han R, Wu C. | 05/21/2016 |
| Results show that lower BAI1 expression correlates with poorer patient survival, and high Nestin expression is associated with an increased probability of metastases in breast cancer patients. | Changes in BAI1 and nestin expression are prognostic indicators for survival and metastases in breast cancer and provide opportunities for dual targeted therapies.
Meisen WH, Dubin S, Sizemore ST, Mathsyaraja H, Thies K, Lehman NL, Boyer P, Jaime-Ramirez AC, Elder JB, Powell K, Chakravarti A, Ostrowski MC, Kaur B., Free PMC Article | 10/3/2015 |
| recognition of apoptotic cells by BAI1 contributes to their clearance in the human gastric mucosa and this is associated with anti-inflammatory effects | Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells.
Das S, Sarkar A, Ryan KA, Fox S, Berger AH, Juncadella IJ, Bimczok D, Smythies LE, Harris PR, Ravichandran KS, Crowe SE, Smith PD, Ernst PB., Free PMC Article | 06/21/2014 |
| findings demonstrate that BAI1 is a synaptic receptor that can activate both the Rho and ERK pathways, with the N-terminal and C-terminal regions of the receptor playing key roles in the regulation of BAI1 signaling activity | Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.
Stephenson JR, Paavola KJ, Schaefer SA, Kaur B, Van Meir EG, Hall RA., Free PMC Article | 10/26/2013 |
| The results of this study indicated that BAI1 plays an important role in synaptogenesis that is mechanistically distinct from its role in phagocytosis. | The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.
Duman JG, Tzeng CP, Tu YK, Munjal T, Schwechter B, Ho TS, Tolias KF., Free PMC Article | 06/22/2013 |
| Proprotein convertases, primarily furin, activate latent matrix metalloproteinase-14, which then directly cleaves BAI1 to release the bioactive fragment. | A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40 kDa vasculostatin from tumor suppressor BAI1.
Cork SM, Kaur B, Devi NS, Cooper L, Saltz JH, Sandberg EM, Kaluz S, Van Meir EG., Free PMC Article | 05/18/2013 |
| MBD2 overexpression during gliomagenesis may drive tumor growth by suppressing the antiangiogenic activity of a key tumor BAI1. | Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1.
Zhu D, Hunter SB, Vertino PM, Van Meir EG., Free PMC Article | 10/29/2011 |
| BAI1 was expressed in cerebral neurons but not astrocytes. It was localized in the cytoplasm and cell membrane. BAI1 protein may play an important role in synapse formation and signal transduction | Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells.
Mori K, Kanemura Y, Fujikawa H, Nakano A, Ikemoto H, Ozaki I, Matsumoto T, Tamura K, Yokota M, Arita N. | 01/21/2010 |
| brain-specific angiogenesis inhibitor 1 over-expression suppresses tumour angiogenesis | Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis.
Duda DG, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, Horii A, Tani K, Asano S, Nakamura Y, Matsuno S., Free PMC Article | 01/21/2010 |
| BAI1 was widely expressed in normal brain but was absent in 28 glioma cell lines and in the majority of human glioblastoma investigated. BAI1 expression did not correlate with TP53 status | Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression.
Kaur B, Brat DJ, Calkins CC, Van Meir EG., Free PMC Article | 01/21/2010 |