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    ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 [ Homo sapiens (human) ]

    Gene ID: 57535, updated on 6-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis.

    ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis.
    Cho CJ, Park D, Mills JC., Free PMC Article

    02/12/2022
    Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer.

    Prognostic role of TSPAN1, KIAA1324 and ESRP1 in prostate cancer.
    Stinnesbeck M, Kristiansen A, Ellinger J, Hauser S, Egevad L, Tolkach Y, Kristiansen G., Free PMC Article

    03/28/2021
    Inceptor counteracts insulin signalling in beta-cells to control glycaemia.

    Inceptor counteracts insulin signalling in β-cells to control glycaemia.
    Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H.

    03/13/2021
    Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas.

    Altered Expression of Three EGFR Posttranslational Regulators MDGI, MIG6, and EIG121 in Invasive Breast Carcinomas.
    Meseure D, Drak Alsibai K, Vacher S, Hatem R, Nicolas A, Callens C, Lerebours F, Bieche I., Free PMC Article

    01/16/2021
    it was found that EIG121 exerted dual functions in the regulation of autophagy and stemness not only in normal JEC cells but also JEC obtained CSCs. These findings could be useful for developing targeted therapies for endometrial carcinoma

    Autophagy plays an important role in stemness mediation and the novel dual function of EIG121 in both autophagy and stemness regulation of endometrial carcinoma JEC cells.
    Ran X, Zhou P, Zhang K.

    05/26/2018
    The STR in the upstream regulatory region of EIG121 is highly polymorphic, but is not associated with the risk of developing breast or endometrial cancer in the cohorts analysed here

    A novel polymorphic repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is not associated with the risk of developing breast or endometrial cancer.
    Bolton KA, Holliday EG, Attia J, Bowden NA, Avery-Kiejda KA, Scott RJ., Free PMC Article

    02/4/2017
    A tumor suppressive role of KIAA1324 via inhibition of GRP78 oncoprotein activities in gastric cancer

    KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.
    Kang JM, Park S, Kim SJ, Kim H, Lee B, Kim J, Park J, Kim ST, Yang HK, Kim WH, Kim SJ.

    10/31/2015
    EIG121 may protect cells from cell death by upregulating the autophagy pathway.

    The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress.
    Deng L, Feng J, Broaddus RR., Free PMC Article

    08/20/2011
    High expression of ERalpha and the estrogen-induced gene EIG121 predicts shorter overall survival in patients with high-grade serous ovarian carcinoma.

    Molecular clustering based on ERα and EIG121 predicts survival in high-grade serous carcinoma of the ovary/peritoneum.
    Schlumbrecht MP, Xie SS, Shipley GL, Urbauer DL, Broaddus RR., Free PMC Article

    06/18/2011
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Down-regulation of KIAA1324 protein is associated with endometrial cancer

    Identification of a novel estrogen-regulated gene, EIG121, induced by hormone replacement therapy and differentially expressed in type I and type II endometrial cancer.
    Deng L, Broaddus RR, McCampbell A, Shipley GL, Loose DS, Stancel GM, Pickar JH, Davies PJ.

    01/21/2010
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