| Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer. | Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer.
Wang Y, Wei J, Feng L, Li O, Huang L, Zhou S, Xu Y, An K, Zhang Y, Chen R, He L, Wang Q, Wang H, Du Y, Liu R, Huang C, Zhang X, Yang YG, Kan Q, Tian X., Free PMC Article | 05/11/2023 |
| Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation. | Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation.
Sun J, Zhou C, Zhao Y, Zhang X, Chen W, Zhou Q, Hu B, Gao D, Raatz L, Wang Z, Nelson PJ, Jiang Y, Ren N, Bruns CJ, Zhou H., Free PMC Article | 08/21/2021 |
| QSOX1 promotes mitochondrial apoptosis of hepatocellular carcinoma cells during anchorage-independent growth by inhibiting lipid synthesis. | QSOX1 promotes mitochondrial apoptosis of hepatocellular carcinoma cells during anchorage-independent growth by inhibiting lipid synthesis.
Ma Q, Yu M, Zhou B, Zhou H. | 03/20/2021 |
| Hypoxia-induced upregulation of QSOX1 and a consequent elevation in intracellular H2O2 increased apoptosis in placentae of pregnancies complicated by Preeclampsia. | QSOX1 regulates trophoblastic apoptosis in preeclampsia through hydrogen peroxide production.
Li J, Tong C, Xu P, Wang L, Han TL, Wen L, Luo X, Tan B, Zhu F, Gui S, Gao R, Qi H, Baker PN. | 01/25/2020 |
| mutation of a conserved cis-proline amino acid, analogous to a mutation used to trap substrates of a bacterial disulfide catalyst, has a dramatic effect on the physiological function of the mammalian disulfide catalyst QSOX1. | cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures.
Javitt G, Grossman-Haham I, Alon A, Resnick E, Mutsafi Y, Ilani T, Fass D., Free PMC Article | 01/25/2020 |
| QSOX1 might be a lung cancer tissue-derived biomarker and be involved in the promotion of lung cancers, and thus can be a therapeutic target for lung cancers. | Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis.
Sung HJ, Ahn JM, Yoon YH, Na SS, Choi YJ, Kim YI, Lee SY, Lee EB, Cho S, Cho JY., Free PMC Article | 02/2/2019 |
| This study provides a key example of the effect of glycosylation on Golgi exit and contributes to an understanding of late secretory sorting and quality control. | Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization.
Horowitz B, Javitt G, Ilani T, Gat Y, Morgenstern D, Bard FA, Fass D. | 12/22/2018 |
| High QSOX1 expression correlates with tumor invasiveness | High expression of QSOX1 is associated with tumor invasiveness and high grades groups in prostate cancer.
Baek JA, Song PH, Ko Y, Gu MJ. | 10/27/2018 |
| High QSOX1 expression is a strong and independent factor of reduced survival in breast cancer and may represent a biomarker for aggressive disease and a potential treatment target | QSOX1 expression is associated with aggressive tumor features and reduced survival in breast carcinomas.
Knutsvik G, Collett K, Arnes J, Akslen LA, Stefansson IM. | 01/13/2018 |
| Data indicate ebselen as an in vitro inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1) enzymatic activity. | Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.
Hanavan PD, Borges CR, Katchman BA, Faigel DO, Ho TH, Ma CT, Sergienko EA, Meurice N, Petit JL, Lake DF., Free PMC Article | 05/21/2016 |
| QSOX1 immunoexpression was observed in the non-neoplastic cerebellum samples and the medulloblastoma samples | Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas.
Sobral AC, Neto VM, Traiano G, Percicote AP, Gugelmin ES, de Souza CM, Nakao L, Torres LF, de Noronha L., Free PMC Article | 03/19/2016 |
| High levels of QSOX1 RNA expression is associated with breast cancer. | Expression of quiescin sulfhydryl oxidase 1 is associated with a highly invasive phenotype and correlates with a poor prognosis in Luminal B breast cancer.
Katchman BA, Ocal IT, Cunliffe HE, Chang YH, Hostetter G, Watanabe A, LoBello J, Lake DF., Free PMC Article | 04/4/2015 |
| these studies suggest that QSOX1 is a predictive biomarker for luminal cancers and that it may be a useful target for elusive luminal B disease | Illuminating luminal B: QSOX1 as a subtype-specific biomarker.
Das P, Siegers GM, Postovit LM., Free PMC Article | 03/21/2015 |
| QSOX1 may be revealed as an important player in cancer detection and prognosis. Defining the mechanism(s) of QSOX1 activity in tumors and in in vivo models will provide important insights into how to target QSOX1 with anti-neoplastic agents. | The emerging role of QSOX1 in cancer.
Lake DF, Faigel DO., Free PMC Article | 02/28/2015 |
| Examination of the unusual kinetics of QSOX1 toward cysteine and glutathione at low micromolar concentrations suggests that circulating QSOX1 is unlikely to significantly contribute to the oxidation of these monothiols in plasma | Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase.
Israel BA, Jiang L, Gannon SA, Thorpe C., Free PMC Article | 11/22/2014 |
| QSOX1 may be involved in neuroblastoma differentiation and regression and may thus function as a biomarker for identifying risk groups for this neoplasm. | Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas.
Araújo DG, Nakao L, Gozzo P, Souza CD, Balderrama V, Gugelmin ES, Kuczynski AP, Olandoski M, de Noronha L., Free PMC Article | 11/22/2014 |
| QSOX1 is induced by hypoxic stimuli and identified that QSOX1 is a direct target of HIF-1. | HIF1 contributes to hypoxia-induced pancreatic cancer cells invasion via promoting QSOX1 expression.
Shi CY, Fan Y, Liu B, Lou WH. | 04/19/2014 |
| Data suggest that isoenzyme QSOX1A is secreted from mammalian cells despite transmembrane domain; QSOX1A is cleaved at internal sites and processed within Golgi apparatus to yield soluble enzyme that forms dimer upon cleavage of C-terminal domain. | Proteolytic processing of QSOX1A ensures efficient secretion of a potent disulfide catalyst.
Rudolf J, Pringle MA, Bulleid NJ., Free PMC Article | 11/16/2013 |
| QSOX1 is a potential new prognostic marker which may prove of use in the staging of breast tumours and the stratification of breast cancer patients. | Elevated transcription of the gene QSOX1 encoding quiescin Q6 sulfhydryl oxidase 1 in breast cancer.
Soloviev M, Esteves MP, Amiri F, Crompton MR, Rider CC., Free PMC Article | 09/7/2013 |
| QSOX1 activity was required for incorporation of laminin into the extracellular matrix (ECM) synthesized by fibroblasts, and ECM produced without QSOX1 was defective in supporting cell-matrix adhesion. | A secreted disulfide catalyst controls extracellular matrix composition and function.
Ilani T, Alon A, Grossman I, Horowitz B, Kartvelishvily E, Cohen SR, Fass D. | 07/20/2013 |
| crystal structure | The dynamic disulphide relay of quiescin sulphydryl oxidase.
Alon A, Grossman I, Gat Y, Kodali VK, DiMaio F, Mehlman T, Haran G, Baker D, Thorpe C, Fass D., Free PMC Article | 09/29/2012 |
| These results propose for the first time possible roles for QSOX1 in atherosclerosis. | Quiescin sulfhydryl oxidase (QSOX) is expressed in the human atheroma core: possible role in apoptosis.
de Andrade CR, Stolf BS, Debbas V, Rosa DS, Kalil J, Coelho V, Laurindo FR. | 08/11/2012 |
| Taken together, our results suggest that the mechanism of QSOX1-mediated tumor cell invasion is by activation of MMP-2 and MMP-9. | Quiescin sulfhydryl oxidase 1 promotes invasion of pancreatic tumor cells mediated by matrix metalloproteinases.
Katchman BA, Antwi K, Hostetter G, Demeure MJ, Watanabe A, Decker GA, Miller LJ, Von Hoff DD, Lake DF. | 06/23/2012 |
| Data suggested that the C449-C452 motif was essential for the activity of human QSOX 1b; the C70-C73 motif was fundamental in electron transfer from thiol-containing substrate including reduced proteins, DTT, GSH. | Crucial effect of the first CXXC motif of human QSOX 1b on the activity to different substrates.
Zheng W, Chu Y, Yin Q, Xu L, Yang C, Zhang W, Tang Y, Yang Y. | 06/4/2011 |
| A partial QSOX1 crystal structure reveals a single-chain pseudo-dimer mimicking the quaternary structure of Erv enzymes. | QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains.
Alon A, Heckler EJ, Thorpe C, Fass D. | 05/3/2010 |