| Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-kappaB signaling pathway in aged mice. | Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice.
Qian H, Gao F, Wu X, Lin D, Huang Y, Chen A, Deng J, Gong C, Chen X, Zheng X. | 11/30/2023 |
| Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy. | Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy.
Pfeifer CW, Walsh JT, Santeford A, Lin JB, Beatty WL, Terao R, Liu YA, Hase K, Ruzycki PA, Apte RS., Free PMC Article | 11/10/2023 |
| CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation. | CD200R1 promotes interleukin-17 production by group 3 innate lymphoid cells by enhancing signal transducer and activator of transcription 3 activation.
Linley H, Ogden A, Jaigirdar S, Buckingham L, Cox J, Priestley M, Saunders A., Free PMC Article | 04/19/2023 |
| CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury. | CD200R1 Contributes to Successful Functional Reinnervation after a Sciatic Nerve Injury.
Pannunzio B, Amo-Aparicio J, Julián C, López-Vales R, Peluffo H, Lago N., Free PMC Article | 06/18/2022 |
| MicroRNA-129-5p-regulated microglial expression of the surface receptor CD200R1 controls neuroinflammation. | MicroRNA-129-5p-regulated microglial expression of the surface receptor CD200R1 controls neuroinflammation.
Singh V, Kushwaha S, Ansari JA, Gangopadhyay S, Mishra SK, Dey RK, Giri AK, Patnaik S, Ghosh D., Free PMC Article | 05/21/2022 |
| CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway. | CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway.
Ampudia-Mesias E, Puerta-Martinez F, Bridges M, Zellmer D, Janeiro A, Strokes M, Sham YY, Taher A, Castro MG, Moertel CL, Pluhar GE, Olin MR., Free PMC Article | 03/5/2022 |
| The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease. | The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease.
Rabaneda-Lombarte N, Serratosa J, Bové J, Vila M, Saura J, Solà C., Free PMC Article | 11/22/2021 |
| CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke. | CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.
Zhao SC, Heng X, Ya-Ping W, Di L, Wen-Qian W, Ling-Song M, Chu ZH, Xu Y., Free PMC Article | 08/21/2021 |
| CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma. | CD200-CD200R immune checkpoint engagement regulates ILC2 effector function and ameliorates lung inflammation in asthma.
Shafiei-Jahani P, Helou DG, Hurrell BP, Howard E, Quach C, Painter JD, Galle-Treger L, Li M, Loh YE, Akbari O., Free PMC Article | 05/29/2021 |
| Agonists of CD200R1 may be beneficial for eosinophilic pathologies. | CD200R1 regulates eosinophilia during pulmonary fungal infection in mice.
Salek-Ardakani S, Bell T, Jagger CP, Snelgrove RJ, Hussell T., Free PMC Article | 05/30/2020 |
| The results provided evidence that the expression changes of CD200-CD200R1 axis were highly correlated with neovascularization in retina. Activation of this axis showed strong anti-inflammatory and anti-angiogenic effects in an oxygen-induced retinopathy model, which revealed a new potential therapeutic target for retinal neovascularization treatment. | Anti-angiogenic and anti-inflammatory effects of CD200-CD200R1 axis in oxygen-induced retinopathy mice model.
Hu Y, Wei T, Gao S, Cheng Q. | 03/21/2020 |
| blockade of the endogenous ligand CD200 prevented the tumorigenic effect of CD200R-expressing myeloid cells in the tumor microenvironment, whereas agonistic anti-CD200R has no effect on tumor development | The pro-tumor effect of CD200 expression is not mimicked by agonistic CD200R antibodies.
Pilch Z, Tonecka K, Skorzynski M, Sas Z, Braniewska A, Kryczka T, Boon L, Golab J, Meyaard L, Rygiel TP., Free PMC Article | 10/26/2019 |
| Study in CD200R-/- mice revealed that CD200R deficiency leads to enhanced bacterial burden in neutrophils. CD200R-deficient neutrophils display significantly reduced reactive oxygen species production (ROS), suggesting that CD200R-mediated ROS production in neutrophils is necessary for limiting F.tularensis colonization and proliferation. Overall, data show that CD200R promotes the antimicrobial properties of neutrophils. | CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality.
Casulli J, Fife ME, Houston SA, Rossi S, Dow J, Williamson ED, Clark GC, Hussell T, D'Elia RV, Travis MA., Free PMC Article | 06/15/2019 |
| This study demonstrated that loss of CD200R1 led to high mortality, increased rates of post-stroke infection, and enhanced entry of peripheral leukocytes into the brain after ischemia, with no increase in infarct size. | CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke.
Ritzel RM, Al Mamun A, Crapser J, Verma R, Patel AR, Knight BE, Harris N, Mancini N, Roy-O'Reilly M, Ganesh BP, Liu F, McCullough LD., Free PMC Article | 06/1/2019 |
| Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 through its receptor (CD200R) | CD200R/Foxp3-mediated signalling regulates microglial activation.
Yi MH, Zhang E, Kim JJ, Baek H, Shin N, Kim S, Kim SR, Kim HR, Lee SJ, Park JB, Kim Y, Kwon OY, Lee YH, Oh SH, Kim DW., Free PMC Article | 06/30/2018 |
| In adoptive therapy of disseminated leukemia, CD200R-CD28-transduced leukemia-specific CD8 T cells eradicated otherwise lethal disease more efficiently than wild-type cells and bypassed the requirement for interleukin-2 administration to sustain in vivo activity. | A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia.
Oda SK, Daman AW, Garcia NM, Wagener F, Schmitt TM, Tan X, Chapuis AG, Greenberg PD., Free PMC Article | 12/23/2017 |
| we revealed a critical role for CD200R signaling in limiting the growth and metastasis of CD200(+) tumors. | A Critical Role for CD200R Signaling in Limiting the Growth and Metastasis of CD200+ Melanoma.
Liu JQ, Talebian F, Wu L, Liu Z, Li MS, Wu L, Zhu J, Markowitz J, Carson WE 3rd, Basu S, Bai XF., Free PMC Article | 08/5/2017 |
| CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization. | CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization.
Horie S, Robbie SJ, Liu J, Wu WK, Ali RR, Bainbridge JW, Nicholson LB, Mochizuki M, Dick AD, Copland DA., Free PMC Article | 10/31/2015 |
| Data show that neutrophil infiltration of tissues was markedly decreased in CD200 antigen (tg) transgenic animals and increased in CD200 receptor 1 CD200R1(-/-) knockout mice. | Bidirectional effect of CD200 on breast cancer development and metastasis, with ultimate outcome determined by tumor aggressiveness and a cancer-induced inflammatory response.
Erin N, Podnos A, Tanriover G, Duymuş Ö, Cote E, Khatri I, Gorczynski RM. | 10/17/2015 |
| we show a causal role for the CD200-CD200R inhibitory axis in arteriogenesis in a murine hindlimb ischemia model. | The CD200-CD200 receptor inhibitory axis controls arteriogenesis and local T lymphocyte influx.
van den Borne P, Rygiel TP, Hoogendoorn A, Westerlaken GH, Boon L, Quax PH, Pasterkamp G, Hoefer IE, Meyaard L., Free PMC Article | 08/8/2015 |
| CD200-CD200R1 interaction in glial cells is involved in the neuroprotective action of PPAR-gamma agonists. | CD200R1 and CD200 expression are regulated by PPAR-γ in activated glial cells.
Dentesano G, Serratosa J, Tusell JM, Ramón P, Valente T, Saura J, Solà C. | 12/20/2014 |
| [review] Influenza-infected CD200R1-deficient mice show less bacterial load and exhibit decreased pathogenesis and mortality than wild-type animals following streptococcal pneumonia superinfection. | The CD200-CD200R1 inhibitory signaling pathway: immune regulation and host-pathogen interactions.
Vaine CA, Soberman RJ., Free PMC Article | 05/10/2014 |
| Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-beta abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice, and suggest combined role of mast cells and Tregs. | Anti-CD200R2, anti-IL-9, anti-IL-35, or anti-TGF-β abolishes increased graft survival and Treg induction induced in cromolyn-treated CD200R1KO.CD200tg mice.
Gorczynski R, Yu K, Chen Z. | 02/22/2014 |
| AML1-ETO upregulated CD200R1 in lineage(-) cells, which was characteristic of AML1-ETO-positive leukemia in mice. | Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice.
Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T. | 11/16/2013 |
| a role for both graft and host CD200/CD200R expression in increased allograft survival. | Effect of CD200 and CD200R1 expression within tissue grafts on increased graft survival in allogeneic recipients.
Yu K, Chen Z, Gorczynski R. | 08/10/2013 |