| ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression. | ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression.
Wu X, Wang Y, Chen B, Liu Y, Li F, Ou Y, Zhang H, Wu X, Li X, Wang L, Rong W, Liu J, Xing M, Zhao X, Liu H, Ge L, Lv A, Wang L, Wang Z, Li M, Zhang H., Free PMC Article | 02/1/2024 |
| ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis. | ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.
Bao J, Ye B, Ren Y., Free PMC Article | 09/3/2022 |
| ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer. | ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer.
Cai J, Hu D, Sakya J, Sun T, Wang D, Wang L, Mao X, Su Z., Free PMC Article | 09/25/2021 |
| A20-Binding Inhibitor of Nuclear Factor-kappaB Targets beta-Arrestin2 to Attenuate Opioid Tolerance. | A20-Binding Inhibitor of Nuclear Factor-κB Targets β-Arrestin2 to Attenuate Opioid Tolerance.
Zhang Y, Zhou P, Lu F, Su R, Gong Z. | 09/25/2021 |
| The ABIN-1 heterozygosity sensitizes innate immune response of Abin-1(+/)(-) mice in vivo by promoting the production of proinflammatory cytokines, which can be blocked upon inhibition of RIPK1 kinase. | ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J., Free PMC Article | 10/3/2020 |
| The splenic iMo of ABIN1[D485N] mice displayed high expression of mRNAs encoding proteins controlling cell division and were actively dividing; this may underlie the increased pMo and MoDC numbers, which are derived from iMo. | Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice.
Nanda SK, Petrova T, Marchesi F, Gierlinski M, Razsolkov M, Lee KL, Wright SW, Rao VR, Cohen P, Arthur JSC., Free PMC Article | 07/25/2020 |
| These data show that the disease susceptibility proteins A20 and ABIN-1 synergistically prevent intestinal inflammation by restricting IEC death and preserving tissue integrity. | A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.
Kattah MG, Shao L, Rosli YY, Shimizu H, Whang MI, Advincula R, Achacoso P, Shah S, Duong BH, Onizawa M, Tanbun P, Malynn BA, Ma A., Free PMC Article | 06/29/2019 |
| It has been proposed that ABIN-1 provides a critical link between methionine1 ubiquitylation mediated by the LUBAC complex and lysine63 deubiquitylation by phospho-A20 to modulate the activation of RIPK1. | ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
Dziedzic SA, Su Z, Jean Barrett V, Najafov A, Mookhtiar AK, Amin P, Pan H, Sun L, Zhu H, Ma A, Abbott DW, Yuan J., Free PMC Article | 04/6/2019 |
| Reduced expression of TNIP1 was determined in hepatic ischemia/reperfusion (I/R) injury compared to normal mice. Then, TNIP1 transgene mice were used to determine the effects of TNIP1 on mice after treatment for I/R. | TNIP1 alleviates hepatic ischemia/reperfusion injury via the TLR2-Myd88 pathway.
Zhang Y, Lei X, Li W, Ding X, Bai J, Wang J, Wu G. | 10/13/2018 |
| the data establish Tnip1 as a critical regulator of IL-17 biology and reveal a causal role of keratinocytes in the pathogenesis of psoriasis. | Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function.
Ippagunta SK, Gangwar R, Finkelstein D, Vogel P, Pelletier S, Gingras S, Redecke V, Häcker H., Free PMC Article | 02/3/2018 |
| These studies define a novel role for ABIN1 dysfunction and NF-kappaB in mediating glomerulonephritis through proinflammatory activation of podocytes. | ABIN1 Determines Severity of Glomerulonephritis via Activation of Intrinsic Glomerular Inflammation.
Korte EA, Caster DJ, Barati MT, Tan M, Zheng S, Berthier CC, Brosius FC 3rd, Vieyra MB, Sheehan RM, Kosiewicz M, Wysoczynski M, Gaffney PM, Salant DJ, McLeish KR, Powell DW., Free PMC Article | 12/2/2017 |
| Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 | Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1.
Nanda SK, Lopez-Pelaez M, Arthur JS, Marchesi F, Cohen P., Free PMC Article | 07/29/2017 |
| These results suggest that the ABIN1-mediated hyperactivation of IKKs and MAPKs might mediate chronic inflammation and CVD development. | An important role for A20-binding inhibitor of nuclear factor-kB-1 (ABIN1) in inflammation-mediated endothelial dysfunction: an in vivo study in ABIN1 (D485N) mice.
Akbar N, Nanda S, Belch J, Cohen P, Khan F., Free PMC Article | 02/6/2016 |
| studies link ABIN-1 with IL-23 and IL-17, and they provide cellular and molecular mechanisms by which ABIN-1 regulates susceptibility to psoriasis. | Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A., Free PMC Article | 09/21/2013 |
| data reveal ABIN1 as an essential anti-inflammatory component of TLR-signaling pathways that controls C/EBPbeta activity | A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease.
Zhou J, Wu R, High AA, Slaughter CA, Finkelstein D, Rehg JE, Redecke V, Häcker H., Free PMC Article | 01/14/2012 |
| ABIN1 requires its ubiquitin binding domain and cooperates with TAX1BP1 and A20 to restrict antiviral signaling. | ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.
Gao L, Coope H, Grant S, Ma A, Ley SC, Harhaj EW., Free PMC Article | 12/10/2011 |
| the interaction of ABIN1 with polyubiquitin is required to limit the activation of TLR-MyD88 pathways and prevent autoimmunity | Polyubiquitin binding to ABIN1 is required to prevent autoimmunity.
Nanda SK, Venigalla RK, Ordureau A, Patterson-Kane JC, Powell DW, Toth R, Arthur JS, Cohen P., Free PMC Article | 08/27/2011 |
| ABIN-1 inhibits caspase 8 recruitment to FADD (Fas-associated death domain-containing protein) in TNF-induced signalling complexes, preventing caspase 8 cleavage and programmed cell death. | ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.
Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Benedict Yen TS, Woo T, Malynn BA, Ma A., Free PMC Article | 01/21/2010 |
| Using a murine model of allergen-induced asthma, we have demonstrated that adenovirus-mediated delivery of ABIN-1 to the lung epithelium results in a reduction of allergen-induced eosinophil infiltration into the lungs. | Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model.
El Bakkouri K, Wullaert A, Haegman M, Heyninck K, Beyaert R. | 01/21/2010 |