| Cytoneme-like protrusion formation induced by LAR is promoted by receptor dimerization. | Cytoneme-like protrusion formation induced by LAR is promoted by receptor dimerization.
Nguyen MQ, Taniguchi M, Yasumura M, Iguchi T, Sato M., Free PMC Article | 07/30/2022 |
| miR-647 inhibits hepatocellular carcinoma cell progression by targeting protein tyrosine phosphatase receptor type F. | miR-647 inhibits hepatocellular carcinoma cell progression by targeting protein tyrosine phosphatase receptor type F.
Ye X, Qiu R, He X, Hu Z, Zheng F, Huang X, Xie X, Chen F, Ou H, Lin G., Free PMC Article | 02/26/2022 |
| Crystal and solution structures of fragments of the human leucocyte common antigen-related protein. | Crystal and solution structures of fragments of the human leucocyte common antigen-related protein.
Vilstrup J, Simonsen A, Birkefeldt T, Strandbygård D, Lyngsø J, Pedersen JS, Thirup S. | 01/16/2021 |
| Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer. | Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer.
Gan T, Stevens AT, Xiong X, Wen YA, Farmer TN, Li AT, Stevens PD, Golshani S, Weiss HL, Evers BM, Gao T., Free PMC Article | 12/19/2020 |
| PPARgamma inhibits breast cancer progression by upregulating PTPRF expression. | PPARγ inhibits breast cancer progression by upregulating PTPRF expression.
Xu YY, Liu H, Su L, Xu N, Xu DH, Liu HY, Spaner D, Bed-David Y, Li YJ. | 10/24/2020 |
| Data show that protein tyrosine phosphatase receptor type F (PTPRF) activity suppressed CD133/transmembrane 4L six family member 5 (TM4SF5)-mediated sphere growth. | CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF).
Kim S, Cho CY, Lee D, Song DG, Kim HJ, Jung JW, Kim JE, Park D, Lee H, Um H, Park J, Choi Y, Kim Y, Nam SH, Lee JW. | 10/5/2019 |
| transferred nuclear Overhauser effects (trNOEs) have been employed in the docking program HADDOCK to generate models for the LAR-fondaparinux complex. These models are further analyzed by postprocessing energetic analysis to identify key binding interactions. | Structural Characterization of a Heparan Sulfate Pentamer Interacting with LAR-Ig1-2.
Gao Q, Yang JY, Moremen KW, Flanagan JG, Prestegard JH., Free PMC Article | 05/12/2018 |
| PTPRF may have value as a predictive marker to identify which patients can obtain the greatest benefit from erlotinib in the post-first-line setting. | PTPRF Expression as a Potential Prognostic/Predictive Marker for Treatment with Erlotinib in Non-Small-Cell Lung Cancer.
Soulières D, Hirsch FR, Shepherd FA, Bordogna W, Delmar P, Shames DS, Klughammer B. | 06/28/2016 |
| Homozygous truncating PTPRF mutation causes athelia. | Homozygous truncating PTPRF mutation causes athelia.
Borck G, de Vries L, Wu HJ, Smirin-Yosef P, Nürnberg G, Lagovsky I, Ishida LH, Thierry P, Wieczorek D, Nürnberg P, Foley J, Kubisch C, Basel-Vanagaite L. | 09/6/2014 |
| PTPRF is down-regulated in hepatocellular carcinoma-facilitated tumor development. | Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis.
Bera R, Chiou CY, Yu MC, Peng JM, He CR, Hsu CY, Huang HL, Ho UY, Lin SM, Lin YJ, Hsieh SY. | 08/9/2014 |
| Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. | Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.
Song YS, Lee HJ, Prosselkov P, Itohara S, Kim E. | 06/7/2014 |
| LAR functions as a negative regulator of adipogenesis. | Regulation of adipogenic differentiation by LAR tyrosine phosphatase in human mesenchymal stem cells and 3T3-L1 preadipocytes.
Kim WK, Jung H, Kim DH, Kim EY, Chung JW, Cho YS, Park SG, Park BC, Ko Y, Bae KH, Lee SC. | 07/26/2010 |
| Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. | Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
Kwon SK, Woo J, Kim SY, Kim H, Kim E., Free PMC Article | 05/31/2010 |
| the PTPase activity in patients with insulin receptor gene mutation and severe insulin resistance may differ from that in ordinary type 2 diabetes | Protein tyrosine phosphatase regulation in fibroblasts from patients with an insulin receptor gene mutation.
Seki N, Yagi S, Suzuki Y, Shimada F, Taira M, Makino H, Amano K, Yagui K, Saito Y, Hashimoto N. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | The allelic variant of LAR gene promoter -127 bp T-->A is associated with reduced risk of obesity and other features related to insulin resistance.
Miscio G, Tassi V, Coco A, Soccio T, Di Paola R, Prudente S, Baratta R, Frittitta L, Ludovico O, Padovano L, Dallapiccola B, Di Mario U, De Cosmo S, Trischitta V. | 03/13/2008 |
| LAR and Src are identified as Death-associated protein kinase (DAPK) regulators through their reciprocal modification of DAPK Y491/492 residues and establishes a functional link of this DAPK-regulatory circuit to tumor progression. | The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR.
Wang WJ, Kuo JC, Ku W, Lee YR, Lin FC, Chang YL, Lin YM, Chen CH, Huang YP, Chiang MJ, Yeh SW, Wu PR, Shen CH, Wu CT, Chen RH. | 01/21/2010 |
| LAR as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin | Knock-down of LAR protein tyrosine phosphatase induces insulin resistance.
Mander A, Hodgkinson CP, Sale GJ. | 01/21/2010 |
| Regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. | Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development.
Hoogenraad CC, Feliu-Mojer MI, Spangler SA, Milstein AD, Dunah AW, Hung AY, Sheng M. | 01/21/2010 |
| interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs | Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases.
Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J. | 01/21/2010 |
| regulation of expression by cell density through functional E-cadherin complexes | Expression of the leucocyte common antigen-related (LAR) tyrosine phosphatase is regulated by cell density through functional E-cadherin complexes.
Symons JR, LeVea CM, Mooney RA., Free PMC Article | 01/21/2010 |
| Results identify a protein tyrosine phosphatase as a potential substrate of TACE and describe proteolytic processing of PTP-LAR as a means of regulating phosphatase activity downstream and thus under the control of EGFR-mediated signaling pathways. | EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing.
Ruhe JE, Streit S, Hart S, Ullrich A. | 01/21/2010 |
| PS/gamma-secretase-mediated cleavage of LAR controls LAR-beta-catenin interaction, suggesting an essential role for PS/gamma-secretase in the regulation of LAR signaling | Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin.
Haapasalo A, Kim DY, Carey BW, Turunen MK, Pettingell WH, Kovacs DM. | 01/21/2010 |
| LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation | Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.
Tsujikawa K, Ichijo T, Moriyama K, Tadotsu N, Sakamoto K, Sakane N, Fukada S, Furukawa T, Saito H, Yamamoto H. | 01/21/2010 |