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    PVALB parvalbumin [ Homo sapiens (human) ]

    Gene ID: 5816, updated on 5-Mar-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing Neurons.

    The Nature of Prefrontal Cortical GABA Neuron Alterations in Schizophrenia: Markedly Lower Somatostatin and Parvalbumin Gene Expression Without Missing Neurons.
    Dienel SJ, Fish KN, Lewis DA., Free PMC Article

    07/6/2023
    Strontium Binding to alpha-Parvalbumin, a Canonical Calcium-Binding Protein of the ""EF-Hand"" Family.

    Strontium Binding to α-Parvalbumin, a Canonical Calcium-Binding Protein of the "EF-Hand" Family.
    Vologzhannikova AA, Shevelyova MP, Kazakov AS, Sokolov AS, Borisova NI, Permyakov EA, Kircheva N, Nikolova V, Dudev T, Permyakov SE., Free PMC Article

    10/2/2021
    Age-related changes in the number of cresyl-violet-stained, parvalbumin and NMDAR 2B expressing neurons in the human spiral ganglion.

    Age-related changes in the number of cresyl-violet-stained, parvalbumin and NMDAR 2B expressing neurons in the human spiral ganglion.
    Kaur C, Saini S, Pal I, Kumar P, Chandra Sati H, Jacob TG, Bhardwaj DN, Roy TS.

    06/5/2021
    Parvalbumin immunohistochemical expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney.

    Parvalbumin immunohistochemical expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney.
    Caliò A, Ammendola S, Brunelli M, Pedron S, Gobbo S, Martignoni G.

    04/13/2021
    Propofol sedation-induced alterations in brain connectivity reflect parvalbumin interneurone distribution in human cerebral cortex.

    Propofol sedation-induced alterations in brain connectivity reflect parvalbumin interneurone distribution in human cerebral cortex.
    Craig MM, Misic B, Pappas I, Adapa RM, Menon DK, Stamatakis EA.

    04/3/2021
    Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk.

    Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk.
    Anderson KM, Collins MA, Chin R, Ge T, Rosenberg MD, Holmes AJ., Free PMC Article

    08/29/2020
    GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons.

    GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons.
    Garst-Orozco J, Malik R, Lanz TA, Weber ML, Xi H, Arion D, Enwright JF 3rd, Lewis DA, O'Donnell P, Sohal VS, Buhl DL., Free PMC Article

    08/22/2020
    PVALB promoter methylation in major depressive disorder and its correlation with major depressive disorder severity indicating a role for epigenetics in this psychiatric disorder.

    Parvalbumin Promoter Methylation Altered in Major Depressive Disorder.
    Thaweethee-Sukjai B, Suttajit S, Thanoi S, Dalton CF, Reynolds GP, Nudmamud-Thanoi S., Free PMC Article

    05/2/2020
    These results provide the first evidence that PVALB promoter methylation is abnormal in schizophrenia and suggest that this epigenetic finding may relate to the reduction of PV expression seen in the disease.

    Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia.
    Fachim HA, Srisawat U, Dalton CF, Reynolds GP.

    04/6/2019
    the Calreticulin deficiency-mediated increase in cell death was not prevented by calbindin-D28k or Parvalbumin.

    Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related Ca(2+)-Binding Proteins Calbindin-D28k and Parvalbumin.
    Wörthmüller J, Oberson A, Salicio V, Blum W, Schwaller B., Free PMC Article

    03/30/2019
    These results demonstrate a specific association between elevated PVALB methylation and METH-induced psychosis.

    Increased DNA methylation in the parvalbumin gene promoter is associated with methamphetamine dependence.
    Veerasakul S, Watiktinkorn P, Thanoi S, Dalton CF, Fachim HA, Nudmamud-Thanoi S, Reynolds GP.

    07/21/2018
    Our data support the hypothesis that the loss of PVALB plays a role in the pathogenesis of thyroid tumors.

    PVALB diminishes [Ca2+] and alters mitochondrial features in follicular thyroid carcinoma cells through AKT/GSK3β pathway.
    Mendes TB, Nozima BH, Budu A, de Souza RB, Braga Catroxo MH, Delcelo R, Gazarini ML, Cerutti JM.

    01/13/2018
    This study showed that the density of parvalbumin was significantly diminished in the basolateral complex in patients with Parkinson Disease.

    α-Synucleinopathy in the Human Amygdala in Parkinson Disease: Differential Vulnerability of Somatostatin- and Parvalbumin-Expressing Neurons.
    Flores-Cuadrado A, Ubeda-Bañon I, Saiz-Sanchez D, Martinez-Marcos A.

    09/23/2017
    The results of this study suggested that innervation from PV-containing thalamic nuclei extends across superficial and middle layers of the human dorsolateral prefrontal cortex.

    Ultrastructural analysis of parvalbumin synapses in human dorsolateral prefrontal cortex.
    Glausier JR, Roberts RC, Lewis DA., Free PMC Article

    08/26/2017
    This study demonstrated that A reduction of PV-positive cells and PV-immunoreactivity was observed exclusively in FCD type I/III specimens compared with cryptogenic tissue from control patients with a poor postsurgical outcome.

    Different parvalbumin and GABA expression in human epileptogenic focal cortical dysplasia.
    Medici V, Rossini L, Deleo F, Tringali G, Tassi L, Cardinale F, Bramerio M, de Curtis M, Garbelli R, Spreafico R.

    06/24/2017
    excitatory synapse density is lower selectively on parvalbumin interneurons in schizophrenia and predicts the activity-dependent down-regulation of parvalbumin and GAD67

    Pathological Basis for Deficient Excitatory Drive to Cortical Parvalbumin Interneurons in Schizophrenia.
    Chung DW, Fish KN, Lewis DA., Free PMC Article

    05/7/2017
    Increased numbers of PVALB neurons and fiber labeling in focal cortical dysplasia compared to nondysplastic epileptic temporal neocortex and postmortem controls may be related to cortical malformation.

    Calcium-binding proteins in focal cortical dysplasia.
    Kuchukhidze G, Wieselthaler-Hölzl A, Drexel M, Unterberger I, Luef G, Ortler M, Becker AJ, Trinka E, Sperk G., Free PMC Article

    10/17/2015
    TRPV1-, TRPV2-, P2X3-, and parvalbumin-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve

    Distribution of TRPVs, P2X3, and parvalbumin in the human nodose ganglion.
    Sato D, Sato T, Urata Y, Okajima T, Kawamura S, Kurita M, Takahashi K, Nanno M, Watahiki A, Kokubun S, Shimizu Y, Kasahara E, Shoji N, Sasano T, Ichikawa H.

    04/4/2015
    This study demonistrated that differentially expressed in PV neurons in subjects with schizophrenia, including genes associated with WNT (wingless-type), NOTCH, and PGE2 (prostaglandin E2) signaling.

    Molecular profiles of parvalbumin-immunoreactive neurons in the superior temporal cortex in schizophrenia.
    Pietersen CY, Mauney SA, Kim SS, Passeri E, Lim MP, Rooney RJ, Goldstein JM, Petreyshen TL, Seidman LJ, Shenton ME, Mccarley RW, Sonntag KC, Woo TU., Free PMC Article

    01/10/2015
    This study showed that the parvalbumin basket cell inputs in the dorsolateral prefrontal cortex were lower in patient with schizophrenia.

    Altered parvalbumin basket cell inputs in the dorsolateral prefrontal cortex of schizophrenia subjects.
    Glausier JR, Fish KN, Lewis DA., Free PMC Article

    08/30/2014
    mRNA labeling at the single cell level shows a significant decrease in parvalbumin expression in Parkinson's (PD) cases; however, neuronal density of parvalbumin-positive neurons was not significantly different between PD patients and controls.

    Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson's disease.
    Lanoue AC, Blatt GJ, Soghomonian JJ., Free PMC Article

    04/12/2014
    This study demonistrated that loss of parvalbium immunoreactive axons in anterolateral columns of spinal cord in patient of lateral sclerosis spinal cords

    Loss of calretinin- and parvalbumin-immunoreactive axons in anterolateral columns beyond the corticospinal tracts of amyotrophic lateral sclerosis spinal cords.
    Hayashi S, Amari M, Okamoto K.

    02/8/2014
    A subpopulation of projection neurons containing calcium-binding protein parvalbumin (PV) is identified in a precise mapping of the GABAergic cortical distribution.

    Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse.
    McKenna JT, Yang C, Franciosi S, Winston S, Abarr KK, Rigby MS, Yanagawa Y, McCarley RW, Brown RE., Free PMC Article

    11/2/2013
    Parvalbumin neurons decrease the drive of the input to the visual cortex in contrast sensitivity.

    Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1.
    Nienborg H, Hasenstaub A, Nauhaus I, Taniguchi H, Huang ZJ, Callaway EM., Free PMC Article

    10/19/2013
    Data show calbindin (CB)- and tyrosine hydroxylase (TH)-cells were distributed in the three striatal territories, and the density of calretinin (CR) and parvalbumin (PV) interneurons were more abundant in the associative and sensorimotor striatum.

    Distribution of GABAergic interneurons and dopaminergic cells in the functional territories of the human striatum.
    Bernácer J, Prensa L, Giménez-Amaya JM., Free PMC Article

    06/16/2012
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