| Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target. | Unveiling the role of PYGB in pancreatic cancer: a novel diagnostic biomarker and gene therapy target.
Ren LK, Lu RS, Fei XB, Chen SJ, Liu P, Zhu CH, Wang X, Pan YZ., Free PMC Article | 03/19/2024 |
| PYGB facilitates cell proliferation and invasiveness in non-small cell lung cancer by activating the Wnt-beta-catenin signaling pathway. | PYGB facilitates cell proliferation and invasiveness in non-small cell lung cancer by activating the Wnt-β-catenin signaling pathway.
Xiao L, Wang W, Huangfu Q, Tao H, Zhang J. | 05/22/2021 |
| PYGB Promoted Tumor Progression by Regulating Wnt/beta-Catenin Pathway in Gastric Cancer. | PYGB Promoted Tumor Progression by Regulating Wnt/β-Catenin Pathway in Gastric Cancer.
Xia B, Zhang K, Liu C., Free PMC Article | 01/9/2021 |
| Authors showed that PYGB was upregulated in ovarian cancer tissue and high level of PYGB expression is markedly correlated with poor prognosis of ovarian cancer patients. PYGB knockdown significantly suppressed ovarian cancer cell proliferation, invasion and migration. | Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3p.
Zhou Y, Jin Z, Wang C. | 05/16/2020 |
| This method allows absolute quantitative measurement when conventional calibration curve fails to provide accurate estimation of cardiac biomarkers, especially at low and high concentration ranges. Under an optimised condition, the LOD of our SERS-based muPAD was identified at 8, 10, and 1pgmL(-1), for GPBB, CK-MB and cTnT, respectively, which is well below the clinical cutoff values. | Using SERS-based microfluidic paper-based device (μPAD) for calibration-free quantitative measurement of AMI cardiac biomarkers.
Lim WY, Goh CH, Thevarajah TM, Goh BT, Khor SM. | 04/4/2020 |
| we identify PYGB as a novel metabolic target with potential applications in the management and/or prevention of metastasis in breast cancer. | Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes.
Altemus MA, Goo LE, Little AC, Yates JA, Cheriyan HG, Wu ZF, Merajver SD., Free PMC Article | 03/14/2020 |
| The mean plasma GPBB levels were higher in acute ischemic stroke cases than in controls. | New biomarker for acute ischaemic stroke: plasma glycogen phosphorylase isoenzyme BB.
Park KY, Ay I, Avery R, Caceres JA, Siket MS, Pontes-Neto OM, Zheng H, Rost NS, Furie KL, Sorensen AG, Koroshetz WJ, Ay H. | 07/13/2019 |
| PYGB silencing suppressed the growth and promoted the apoptosis of prostate cancer cells by affecting the NFkappaB/Nrf2 signaling pathway. | Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF‑κB/Nrf2 signaling pathway.
Wang Z, Han G, Liu Q, Zhang W, Wang J., Free PMC Article | 01/12/2019 |
| PYGB siRNA exerted an inhibitory effect on the cell viability of the human osteosarcoma cells MG63 and HOS by blocking the Caspase/Bcl and CDK1 signaling pathway, highlighting novel potential therapeutic methods for treating osteosarcoma. | PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines.
Zhang S, Zhou Y, Zha Y, Yang Y, Wang L, Li J, Jin W., Free PMC Article | 10/20/2018 |
| Using cysteine chemical labeling, mass spectrometry, and site-directed mutagenesis approaches, we show that thiram (and certain of its metabolites) alters the activity of bGP through the formation of an intramolecular disulfide bond (Cys(318)-Cys(326)), known to act as a redox switch that precludes the allosteric activation of bGP by AMP. | Molecular Mechanisms of Allosteric Inhibition of Brain Glycogen Phosphorylase by Neurotoxic Dithiocarbamate Chemicals.
Mathieu C, Bui LC, Petit E, Haddad I, Agbulut O, Vinh J, Dupret JM, Rodrigues-Lima F., Free PMC Article | 06/3/2017 |
| disulfide bond acts as a redox switch that precludes the allosteric activation of the enzyme by AMP without affecting its activation by phosphorylation. This unique regulatory feature of bGP sheds new light on the isoform-specific regulation of glycogen phosphorylase and glycogen metabolism. | An Isozyme-specific Redox Switch in Human Brain Glycogen Phosphorylase Modulates Its Allosteric Activation by AMP.
Mathieu C, Duval R, Cocaign A, Petit E, Bui LC, Haddad I, Vinh J, Etchebest C, Dupret JM, Rodrigues-Lima F., Free PMC Article | 05/27/2017 |
| the bGP structures reveal molecular features unique to the brain isozyme that provide a deeper understanding of the differences in the activation properties of these allosteric enzymes by the allosteric effector AMP. | Insights into Brain Glycogen Metabolism: THE STRUCTURE OF HUMAN BRAIN GLYCOGEN PHOSPHORYLASE.
Mathieu C, Li de la Sierra-Gallay I, Duval R, Xu X, Cocaign A, Léger T, Woffendin G, Camadro JM, Etchebest C, Haouz A, Dupret JM, Rodrigues-Lima F., Free PMC Article | 05/13/2017 |
| GPBB is a valuable biological marker to predict the prognosis in patient with acute coronary syndrome. | Prognostic information of glycogen phosphorylase isoenzyme BB in patients with suspected acute coronary syndrome.
Lillpopp L, Tzikas S, Ojeda F, Zeller T, Baldus S, Bickel C, Sinning CR, Wild PS, Genth-Zotz S, Warnholtz A, Lackner KJ, Münzel T, Blankenberg S, Keller T. | 04/20/2013 |
| H-FABP and GPBB can contribute to early acute myocardial infarction diagnosis and can distinguish acute myocardial infarction from acute coronary syndrome | Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome.
Cubranic Z, Madzar Z, Matijevic S, Dvornik S, Fisic E, Tomulic V, Kunisek J, Laskarin G, Kardum I, Zaputovic L., Free PMC Article | 09/1/2012 |
| Significant increase in plasma glycoprotein BB in patients with hypertrophic cardiomyopathy. | Plasma glycogen phosphorylase BB is associated with pulmonary artery wedge pressure and left ventricle mass index in patients with hypertrophic cardiomyopathy.
Pudil R, Vasatová M, Lenco J, Tichý M, Rehácek V, Fucíková A, Horácek JM, Vojácek J, Pleskot M, Stulík J, Palicka V. | 11/27/2010 |
| This protein has been found differentially expressed in thalami from patients with schizophrenia. | Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, Falkai P, Schmitt A, Turck CW. | 07/13/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesInvestigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC. | 03/25/2009 |
| Brain-type glycogen phosphorylase is expressed in non-small-cell lung carcinoma, particularly adenocarcinomas, and is an independent poor prognostic factor. | Clinicopathological significance of BGP expression in non-small-cell lung carcinoma: relationship with histological type, microvessel density and patients' survival.
Lee MK, Kim JH, Lee CH, Kim JM, Kang CD, Kim YD, Choi KU, Kim HW, Kim JY, Park DY, Sol MY. | 01/21/2010 |