| Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA. | Alternative splicing of BCL-x is controlled by RBM25 binding to a G-quadruplex in BCL-x pre-mRNA.
Le Sénéchal R, Keruzoré M, Quillévéré A, Loaëc N, Dinh VT, Reznichenko O, Guixens-Gallardo P, Corcos L, Teulade-Fichou MP, Granzhan A, Blondel M., Free PMC Article | 11/15/2023 |
| Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome. | Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome.
Zanoni P, Panteloglou G, Othman A, Haas JT, Meier R, Rimbert A, Futema M, Abou Khalil Y, Norrelykke SF, Rzepiela AJ, Stoma S, Stebler M, van Dijk F, Wijers M, Wolters JC, Dalila N, Huijkman NCA, Smit M, Gallo A, Carreau V, Philippi A, Rabès JP, Boileau C, Visentin M, Vonghia L, Weyler J, Francque S, Verrijken A, Verhaegen A, Van Gaal L, van der Graaf A, van Rosmalen BV, Robert J, Velagapudi S, Yalcinkaya M, Keel M, Radosavljevic S, Geier A, Tybjaerg-Hansen A, Varret M, Rohrer L, Humphries SE, Staels B, van de Sluis B, Kuivenhoven JA, von Eckardstein A. | 02/26/2022 |
| Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma. | Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma.
Zhang YF, Wang YX, Zhang N, Lin ZH, Wang LR, Feng Y, Pan Q, Wang L., Free PMC Article | 11/13/2021 |
| Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer. | Systematic profiling of alternative splicing events and splicing factors in left- and right-sided colon cancer.
Huang X, Liu J, Mo X, Liu H, Wei C, Huang L, Chen J, Tian C, Meng Y, Wu G, Xie W, P C FJ, Liu Z, Tang W., Free PMC Article | 10/24/2020 |
| RBM25 binds directly to circAMOTL1L and induces its biogenesis, whereas p53 regulates EMT via direct activation of RBM25 gene. | Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway.
Yang Z, Qu CB, Zhang Y, Zhang WF, Wang DD, Gao CC, Ma L, Chen JS, Liu KL, Zheng B, Zhang XH, Zhang ML, Wang XL, Wen JK, Li W., Free PMC Article | 05/4/2019 |
| controls the splicing of key genes, including those encoding the apoptotic regulator BCL-X and the MYC inhibitor BIN1 | The splicing factor RBM25 controls MYC activity in acute myeloid leukemia.
Ge Y, Schuster MB, Pundhir S, Rapin N, Bagger FO, Sidiropoulos N, Hashem N, Porse BT., Free PMC Article | 02/16/2019 |
| Data suggest that RBM25 is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 = RNA binding motif protein 25; SRSF2 = serine- and arginine-rich splicing factor 2) | RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation.
Carlson SM, Soulette CM, Yang Z, Elias JE, Brooks AN, Gozani O., Free PMC Article | 08/26/2017 |
| Structure-guided mutagenesis reveals a positively charged nucleic-acid-binding surface in the RBM25 PWI domain | Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region.
Gong D, Yang F, Li F, Qian D, Wu M, Shao Z, Wu M, Wu J, Shi Y., Free PMC Article | 03/30/2013 |
| RBM25/LUC7L3-mediated abnormal SCN5A mRNA splicing reduced Na+ channel current 91.1+/-9.3% to a range known to cause sudden death. | Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure.
Gao G, Xie A, Huang SC, Zhou A, Zhang J, Herman AM, Ghassemzadeh S, Jeong EM, Kasturirangan S, Raicu M, Sobieski MA 2nd, Bhat G, Tatooles A, Benz EJ Jr, Kamp TJ, Dudley SC Jr., Free PMC Article | 11/12/2011 |
| These data suggest a novel mode for Bcl-x(S) 5' ss activation in which binding of RBM25 with exonic element CGGGCA may stabilize the pre-mRNA-U1 snRNP through interactions with hLuc7A. | Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection.
Zhou A, Ou AC, Cho A, Benz EJ Jr, Huang SC., Free PMC Article | 01/21/2010 |
| RED120 may function to couple splicing with mRNA 3'-end formation. | Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation.
Fortes P, Longman D, McCracken S, Ip JY, Poot R, Mattaj IW, Cáceres JF, Blencowe BJ. | 01/21/2010 |