| Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease. | Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.
Sparkenbaugh EM, Henderson MW, Miller-Awe M, Abrams C, Ilich A, Trebak F, Ramadas N, Vital S, Bohinc D, Bane KL, Chen C, Patel M, Wallisch M, Renné T, Gruber A, Cooley B, Gailani D, Kasztan M, Vercellotti GM, Belcher JD, Gavins FE, Stavrou EX, Key NS, Pawlinski R., Free PMC Article | 04/19/2023 |
| FXII regulates the formation of deep vein thrombosis via the PI3K/AKT signaling pathway in mice. | FXII regulates the formation of deep vein thrombosis via the PI3K/AKT signaling pathway in mice.
Meng Y, Yin Q, Ma Q, Qin H, Zhang J, Zhang B, Pang H, Tian H., Free PMC Article | 11/13/2021 |
| Factor XII protects neurons from apoptosis by epidermal and hepatocyte growth factor receptor-dependent mechanisms. | Factor XII protects neurons from apoptosis by epidermal and hepatocyte growth factor receptor-dependent mechanisms.
Garnier E, Levard D, Ali C, Buendia I, Hommet Y, Gauberti M, Crepaldi T, Comoglio P, Rubio M, Vivien D, Docagne F, Martinez de Lizarrondo S. | 10/30/2021 |
| Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice. | Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice.
Stetter C, Lopez-Caperuchipi S, Hopp-Krämer S, Bieber M, Kleinschnitz C, Sirén AL, Albert-Weißenberger C., Free PMC Article | 06/19/2021 |
| Coagulation factor XII contributes to hemostasis when activated by soil in wounds. | Coagulation factor XII contributes to hemostasis when activated by soil in wounds.
Juang LJ, Mazinani N, Novakowski SK, Prowse ENP, Haulena M, Gailani D, Lavkulich LM, Kastrup CJ., Free PMC Article | 06/19/2021 |
| Use of ""C9/11 Mismatch"" Control siRNA Reveals Sequence-Related Off-Target Effect on Coagulation of an siRNA Targeting Mouse Coagulation Factor XII. | Use of "C9/11 Mismatch" Control siRNA Reveals Sequence-Related Off-Target Effect on Coagulation of an siRNA Targeting Mouse Coagulation Factor XII.
Heestermans M, de Jong A, van Tilburg S, Reitsma PH, Versteeg HH, Spronk HM, van Vlijmen BJM. | 08/29/2020 |
| Bacterial-type long-chain polyP promotes platelet activation in a FXII-dependent manner in flowing blood, which may contribute to sepsis-associated thrombotic processes, consumptive coagulopathy, and thrombocytopenia. | Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo.
Zilberman-Rudenko J, Reitsma SE, Puy C, Rigg RA, Smith SA, Tucker EI, Silasi R, Merkulova A, McCrae KR, Maas C, Urbanus RT, Gailani D, Morrissey JH, Gruber A, Lupu F, Schmaier AH, McCarty OJT., Free PMC Article | 07/27/2019 |
| FXII and uPAR upregulate neutrophil functions to influence wound healing | Factor XII and uPAR upregulate neutrophil functions to influence wound healing.
Stavrou EX, Fang C, Bane KL, Long AT, Naudin C, Kucukal E, Gandhi A, Brett-Morris A, Mumaw MM, Izadmehr S, Merkulova A, Reynolds CC, Alhalabi O, Nayak L, Yu WM, Qu CK, Meyerson HJ, Dubyak GR, Gurkan UA, Nieman MT, Sen Gupta A, Renné T, Schmaier AH., Free PMC Article | 07/20/2019 |
| Deficiency or pharmacologic blockade of FXII renders mice less susceptible to experimental autoimmune encephalomyelitis (a model of multiple sclerosis) and is accompanied by reduced numbers of interleukin-17A-producing T cells. | Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.
Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG., Free PMC Article | 09/15/2018 |
| FXI protects against sepsis derived from Streptococcus pneumoniae or Klebsiella pneumoniae pneumonia at least in part by enhancing the phagocytic capacity of neutrophils by a mechanism that is independent of activation via FXIIa. | Coagulation factor XI improves host defence during murine pneumonia-derived sepsis independent of factor XII activation.
Stroo I, Zeerleder S, Ding C, Luken BM, Roelofs JJTH, de Boer OJ, Meijers JCM, Castellino FJ, van 't Veer C, van der Poll T. | 05/5/2018 |
| FXII plays an important role in atherosclerotic lesion formation by functioning as a strong inducer of pro-inflammatory cytokines in antigen-presenting cells. | Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice.
Vorlova S, Koch M, Manthey HD, Cochain C, Busch M, Chaudhari SM, Stegner D, Yepes M, Lorenz K, Nolte MW, Nieswandt B, Zernecke A. | 03/3/2018 |
| Genetic deficiency of factor XII diminished brain injury-induced bradykinin release and minimized brain lesion size. | Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa.
Hopp S, Nolte MW, Stetter C, Kleinschnitz C, Sirén AL, Albert-Weissenberger C., Free PMC Article | 01/13/2018 |
| FXI attenuates part of the allergic response to repeated administration of house dust mite in the airways by a mechanism that is independent of activation via FXII | Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII.
Stroo I, Yang J, de Boer JD, Roelofs JJ, van 't Veer C, Castellino FJ, Zeerleder S, van der Poll T. | 06/24/2017 |
| Wild type mice developed carotid artery occlusion when the vessel was exposed to a 3.5% solution of ferric chloride (FeCl3). FXII-deficient mice were resistant to occlusion at 5% FeCl3 and partially resistant at 10% FeCl3. | A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation.
Kokoye Y, Ivanov I, Cheng Q, Matafonov A, Dickeson SK, Mason S, Sexton DJ, Renné T, McCrae K, Feener EP, Gailani D., Free PMC Article | 12/24/2016 |
| the results of this study characterize the mechanism of HAEIII and establish FXII inhibition as a potential therapeutic strategy to interfere with excessive vascular leakage in HAEIII | Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III.
Björkqvist J, de Maat S, Lewandrowski U, Di Gennaro A, Oschatz C, Schönig K, Nöthen MM, Drouet C, Braley H, Nolte MW, Sickmann A, Panousis C, Maas C, Renné T., Free PMC Article | 10/24/2015 |
| FVIIa- and FXIIa-triggered coagulation pathways have distinct but complementary roles in atherothrombus formation. | Factor XII regulates the pathological process of thrombus formation on ruptured plaques.
Kuijpers MJ, van der Meijden PE, Feijge MA, Mattheij NJ, May F, Govers-Riemslag J, Meijers JC, Heemskerk JW, Renné T, Cosemans JM. | 09/13/2014 |
| Inhibiting factor XIIa with rHA-Infestin-4 may present a safe and effective treatment to decrease the morbidity of silent brain ischemia. | Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway.
Chen JW, Figueiredo JL, Wojtkiewicz GR, Siegel C, Iwamoto Y, Kim DE, Nolte MW, Dickneite G, Weissleder R, Nahrendorf M., Free PMC Article | 05/11/2013 |
| PKK or fXII deficiency reduced thrombus formation in both arterial and venous thrombosis models, without an apparent effect on hemostasis. | Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.
Revenko AS, Gao D, Crosby JR, Bhattacharjee G, Zhao C, May C, Gailani D, Monia BP, MacLeod AR., Free PMC Article | 01/7/2012 |
| fXI and fXII contribute to thrombus formation even when factor VIIa/tissue factor initiates thrombosis. | A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo.
Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun MF, White-Adams TC, Smith SA, Hanson SR, McCarty OJ, Renné T, Gruber A, Gailani D., Free PMC Article | 01/1/2011 |
| FXII-mediated fibrin formation is crucial for pathological arterial thrombosis but not for hemostasis | The intrinsic pathway of coagulation is essential for thrombus stability in mice.
Renné T, Nieswandt B, Gailani D. | 01/21/2010 |
| F12 KNOCKOUT MICE, generated to elucidate the biological role(s) of FXII, had a markedly prolonged APTT. Deficiency of murine FXII does not cause thrombophilia or impaired fibrinolysis or affect hemostasis. | Targeted deletion of murine coagulation factor XII gene-a model for contact phase activation in vivo.
Pauer HU, Renné T, Hemmerlein B, Legler T, Fritzlar S, Adham I, Müller-Esterl W, Emons G, Sancken U, Engel W, Burfeind P. | 01/21/2010 |