| Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice. | Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory, Spatial Working Memory, and Dendritic Structure in Mice.
Wang HL, Li JT, Wang H, Sun YX, Liu R, Wang XD, Su YA, Si TM., Free PMC Article | 07/24/2021 |
| Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex. | Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex.
Tomorsky J, Parker PRL, Doe CQ, Niell CM., Free PMC Article | 07/17/2021 |
| Chronic stress impairs male spermatogenesis function and Nectin-3 protein expression in the testis. | Chronic stress impairs male spermatogenesis function and Nectin-3 protein expression in the testis.
Li T, Yao J, Zhang Q, Li Q, Li J, Wang X, Li W, Chen A, Yan J., Free PMC Article | 02/20/2021 |
| Reduced hippocampal nectin-3 expression in newborn animals impairs the dendritic development of principal neurons in the hippocampus. | Postnatal nectin-3 knockdown induces structural abnormalities of hippocampal principal neurons and memory deficits in adult mice.
Liu R, Wang H, Wang HL, Sun YX, Su YA, Wang XD, Li JT, Si TM., Free PMC Article | 06/13/2020 |
| Nectin-3 expressed in dentate gyrus neurons may modulate adult neurogenesis, dendritic spine plasticity and the cognitive effects of early-life stress. | Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory.
Wang XX, Li JT, Xie XM, Gu Y, Si TM, Schmidt MV, Wang XD., Free PMC Article | 06/2/2018 |
| -afadin-specific C-terminal inserts may be involved in its preference of binding to nectin-3 and raise the possibility that there are proteins other than nectins that more preferentially bind s-afadin than l-afadin. | s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin.
Kobayashi R, Kurita S, Miyata M, Maruo T, Mandai K, Rikitake Y, Takai Y. | 05/30/2015 |
| owing to the loss of Nectin-3, hair cells contact each other inappropriately and form abnormal junctions, ultimately resulting in abnormal hair bundle orientation and morphology | Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities.
Fukuda T, Kominami K, Wang S, Togashi H, Hirata K, Mizoguchi A, Rikitake Y, Takai Y. | 03/1/2014 |
| Results indicate that PLEKHA7 plays a cooperative role with nectin and afadin in the proper formation of Adherens junction (AJ) in epithelial cell. | Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.
Kurita S, Yamada T, Rikitsu E, Ikeda W, Takai Y., Free PMC Article | 12/14/2013 |
| This study demonstrated that nectin1- and nectin3-mediated interactions between Cajal-Retzius cells cells and migrating neurons are critical for radial migration. | Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues.
Gil-Sanz C, Franco SJ, Martinez-Garay I, Espinosa A, Harkins-Perry S, Müller U., Free PMC Article | 11/16/2013 |
| Cell adhesion molecule nectin-3 is required for the effects of corticotropin releasing hormone receptor (CRHR)1 on cognition and structural remodeling after early-life stress exposure. | Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss.
Wang XD, Su YA, Wagner KV, Avrabos C, Scharf SH, Hartmann J, Wolf M, Liebl C, Kühne C, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV. | 08/3/2013 |
| Nectin-3, which forms hetero-trans-dimers with nectin-1, undergoes intramembrane cleavage mediated by PS1/gamma-secretase. | Characterization of nectin processing mediated by presenilin-dependent γ-secretase.
Kim J, Chang A, Dudak A, Federoff HJ, Lim ST., Free PMC Article | 01/14/2012 |
| hair cells and supporting cells express nectin-1 and -3, respectively; their interaction mediates the heterotypic adhesion between these 2 cell types; nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia | Nectins establish a checkerboard-like cellular pattern in the auditory epithelium.
Togashi H, Kominami K, Waseda M, Komura H, Miyoshi J, Takeichi M, Takai Y. | 09/10/2011 |
| Results suggest that heterophilic interaction between nectin-1 and nectin-3 recruits desmosomal junctions, and that these are required for proper enamel formation. | Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth.
Yoshida T, Miyoshi J, Takai Y, Thesleff I. | 03/19/2011 |
| expressed in early epithelial structures of the nephron generated from metanephric mesenchyme | Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE., Free PMC Article | 01/21/2010 |
| Nectin plays a novel role in the co-localization of JAM and claudin at the same cell-cell adhesion membrane domains. | Novel role of nectin: implication in the co-localization of JAM-A and claudin-1 at the same cell-cell adhesion membrane domain.
Kuramitsu K, Ikeda W, Inoue N, Tamaru Y, Takai Y. | 01/21/2010 |
| Inactivated nectin-2 and nectin-3 disrupted the nectin-afadin-actin system, and finally the actin filaments disappeared. As a result, the specialization lost the holding function and detachment of spermatids was observed. | Disruption of ectoplasmic specializations between Sertoli cells and maturing spermatids by anti-nectin-2 and anti-nectin-3 antibodies.
Toyama Y, Suzuki-Toyota F, Maekawa M, Ito C, Toshimori K. | 01/21/2010 |
| regulation of E-cadherin-based adhesion involving cellular nectin-1 trans-interacting with nectin-3 is qualitatively different from that involving cellular nectin-3 trans-interacting with nectin-1 and depends on the nectin levels expressed by cells | Separation force measurements reveal different types of modulation of E-cadherin-based adhesion by nectin-1 and -3.
Martinez-Rico C, Pincet F, Perez E, Thiery JP, Shimizu K, Takai Y, Dufour S. | 01/21/2010 |
| These results indicate that the heterophilic trans-interaction between nectin-2 and nectin-3 is essential for the formation and maintenance of Sertoli-spermatid junctions that plays a critical role in spermatid development. | Role of cell adhesion molecule nectin-3 in spermatid development.
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Takai Y. | 01/21/2010 |
| Nectin-3 does not have a role in Necl-5/Tage4- enhanced cell migration | Nectin-like molecule-5/Tage4 enhances cell migration in an integrin-dependent, Nectin-3-independent manner.
Ikeda W, Kakunaga S, Takekuni K, Shingai T, Satoh K, Morimoto K, Takeuchi M, Imai T, Takai Y. | 01/21/2010 |
| nectins and afadin are involved in dynamic epithelial remodeling during mouse development | Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo.
Okabe N, Ozaki-Kuroda K, Nakanishi H, Shimizu K, Takai Y. | 01/21/2010 |
| Overexpressed nectin recruited N-cadherin DN to the nectin-based cell-cell adhesion sites in an afadin-dependent manner. | Role of nectin in formation of E-cadherin-based adherens junctions in keratinocytes: analysis with the N-cadherin dominant negative mutant.
Tanaka Y, Nakanishi H, Kakunaga S, Okabe N, Kawakatsu T, Shimizu K, Takai Y., Free PMC Article | 01/21/2010 |
| nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis | Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions.
Ozaki-Kuroda K, Nakanishi H, Ohta H, Tanaka H, Kurihara H, Mueller S, Irie K, Ikeda W, Sakai T, Wimmer E, Nishimune Y, Takai Y. | 01/21/2010 |
| the possible trans-interaction between the bona fide cell-cell adherens type adhesion system (cadherin/nectin) and the cell-matrix adhesion system (integrin/CD155) by virtue of their nectin-3 and CD155 components, respectively. | Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains.
Mueller S, Wimmer E. | 01/21/2010 |
| The axon-biased localization of Nectin 1 and its trans-interaction with Nectin 3 in cooperation with the cadherin machinery is critical for the ordered association of axons and dendrites. | Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery.
Togashi H, Miyoshi J, Honda T, Sakisaka T, Takai Y, Takeichi M., Free PMC Article | 01/21/2010 |