| Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis in diabetic nephropathy. | Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis in diabetic nephropathy.
Zhao C, Gao J, Li S, Liu Q, Hou X, Xing X, Wang D, Sun M, Wang S, Luo Y., Free PMC Article | 04/24/2021 |
| High DACT1 expression is associated with type 2 diabetes mellitus. | MicroRNA-125b-5p improves pancreatic β-cell function through inhibiting JNK signaling pathway by targeting DACT1 in mice with type 2 diabetes mellitus.
Yu CY, Yang CY, Rui ZL. | 05/25/2019 |
| miR-124 promoted proliferation and induced NSC differentiation to neurons by activation of Wnt/beta-catenin pathway via targeting DACT1, providing a potential target and aiding the development of cell-based therapies for neurological disorders. | miR-124 promotes proliferation and neural differentiation of neural stem cells through targeting DACT1 and activating Wnt/β-catenin pathways.
Jiao S, Liu Y, Yao Y, Teng J. | 12/22/2018 |
| Dapper1 attenuates hepatic gluconeogenesis and lipogenesis in Ttype 2 diabetes. | Dapper1 attenuates hepatic gluconeogenesis and lipogenesis by activating PI3K/Akt signaling.
Kuang JR, Zhang ZH, Leng WL, Lei XT, Liang ZW. | 11/25/2017 |
| Dpr1 promotes the ubiquitination of Dvl2 by pVHL and mediates the protein aggregate-elicited autophagy initiation | The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.
Ma B, Liu B, Cao W, Gao C, Qi Z, Ning Y, Chen YG., Free PMC Article | 08/8/2015 |
| Expression analysis of Dact1-LacZ show high expression levels in multiple mesoderm- and neuroectoderm-derived tissues during embryonic development, but restricted to a small number of postnatal tissues. | Expression analysis of Dact1 in mice using a LacZ reporter.
Suzuki D, Leu NA, Brice AK, Senoo M., Free PMC Article | 02/7/2015 |
| These results support a novel cell-autonomous postsynaptic role for Dact1, in cooperation with Dishevelled-1 and possibly Disrupted in Schizophrenia-1, in the formation of synapses on cortical interneuron dendrites. | Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons.
Arguello A, Yang X, Vogt D, Stanco A, Rubenstein JL, Cheyette BN., Free PMC Article | 02/8/2014 |
| Depletion of Dapper-1 and dishevelled-2 in cardiomyocytes demonstrated that Dapper-1 functions upstream of dishevelled-2 and that activity of both Dapper-1 and dishevelled-2 is essential for activating canonical Wnt signaling. | Dapper-1 induces myocardial remodeling through activation of canonical Wnt signaling in cardiomyocytes.
Hagenmueller M, Riffel JH, Bernhold E, Fan J, Zhang M, Ochs M, Steinbeisser H, Katus HA, Hardt SE. | 07/13/2013 |
| conserved role for Dact1 protein in kinase-regulated biochemistry involving Vangl and Dvl. | All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.
Kivimäe S, Yang XY, Cheyette BN., Free PMC Article | 12/10/2011 |
| Dact1 was upregulated in the dental follicle mesenchyme at the cap stage and subsequently also in the dental papilla at the bell stage, where the expression persisted to the postnatal stages. | Dact1-3 mRNAs exhibit distinct expression domains during tooth development.
Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K., Free PMC Article | 07/12/2010 |
| Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. | Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice.
Wen J, Chiang YJ, Gao C, Xue H, Xu J, Ning Y, Hodes RJ, Gao X, Chen YG., Free PMC Article | 05/31/2010 |
| This study shown that Dact1 plays an important role during dendrite and spine formation in neurons of the mammalian forebrain by promoting activation of Rac | Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain.
Okerlund ND, Kivimäe S, Tong CK, Peng IF, Ullian EM, Cheyette BN., Free PMC Article | 05/3/2010 |
| Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. | Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.
Suriben R, Kivimäe S, Fisher DA, Moon RT, Cheyette BN., Free PMC Article | 01/21/2010 |
| Dact1 regulates adipogenesis through coordinated effects on gene expression that selectively alter intracellular and paracrine/autocrine components of the Wnt/beta-catenin signaling pathway. | Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network.
Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK., Free PMC Article | 01/21/2010 |
| expression of the Dishevelled antagonist Dapper-1 do not suppress the p38 response to Wnt5a stimulation. | Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway.
Ma L, Wang HY. | 01/21/2010 |
| Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis | Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements.
Hunter NL, Hikasa H, Dymecki SM, Sokol SY. | 01/21/2010 |
| The oscillation of Dact1 occurs in phase with the Wnt signaling component Axin2, and out of phase with the Notch signaling component Lfng. | Dact1 presomitic mesoderm expression oscillates in phase with Axin2 in the somitogenesis clock of mice.
Suriben R, Fisher DA, Cheyette BN. | 01/21/2010 |
| Dact1 is detected in the presomitic mesoderm and somites during segmentation, in the limb bud mesenchyme and other mesoderm-derived tissues, and in the central nervous system | Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.
Fisher DA, Kivimäe S, Hoshino J, Suriben R, Martin PM, Baxter N, Cheyette BN. | 01/21/2010 |