| Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos. | Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.
Bendahmane M, Morales A, Kreutzberger AJB, Schenk NA, Mohan R, Bakshi S, Philippe JM, Zhang S, Kiessling V, Tamm LK, Giovannucci DR, Jenkins PM, Anantharam A., Free PMC Article | 02/13/2021 |
| In somata of Purkinje neurons in the cerebellar cortex, both SYT7 (and SYNCRIP) were expressed and co-localized. | Synaptotagmin 7 and SYNCRIP proteins are ubiquitously expressed in the rat brain and co-localize in Purkinje neurons.
Tratnjek L, Živin M, Glavan G. | 02/10/2018 |
| The slowed endocytosis phenotype previously reported after syt1 loss of function can also be triggered by other manipulations that promote asynchronous release such as Sr(2+) substitution and complexin loss of function. The link between asynchronous release and slowed endocytosis was due to selective targeting of fused synaptic vesicles toward slow retrieval by the asynchronous release Ca(2+) sensor synaptotagmin-7. | Synaptotagmin-1- and Synaptotagmin-7-Dependent Fusion Mechanisms Target Synaptic Vesicles to Kinetically Distinct Endocytic Pathways.
Li YC, Chanaday NL, Xu W, Kavalali ET., Free PMC Article | 07/29/2017 |
| Syt7 modulates fusion pore expansion in large secretory organelles. | Synaptotagmin-7 links fusion-activated Ca²⁺ entry and fusion pore dilation.
Neuland K, Sharma N, Frick M., Free PMC Article | 11/21/2015 |
| Immunocytochemistry in rat chromaffin cells indicated that Syt1 was localized in large dense-core vesicles and synaptic-like microvesicles, whereas Syt7 was the predominant isoform present in large dense-core vesicles. | Differential distribution of synaptotagmin-1, -4, -7, and -9 in rat adrenal chromaffin cells.
Matsuoka H, Harada K, Nakamura J, Fukuda M, Inoue M. | 07/23/2011 |
| The Syt7 C2B domain structure is very similar to that of the Syt1 C2B domain and contains three Ca2+-binding sites. | Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J., Free PMC Article | 02/26/2011 |
| Data show that Syt I produced more rapid dilation of fusion pores than syt VII or syt IX, consistent with its role in synchronous synaptic release. | Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions.
Zhang Z, Hui E, Chapman ER, Jackson MB., Free PMC Article | 02/26/2011 |
| Results suggest that Syt VII is the Ca(2+) sensor of DCV fusion machinery and is an essential factor for the establishment and maintenance of the pool size of releasable DCVs. | Silence of Synaptotagmin VII inhibits release of dense core vesicles in PC12 cells.
Li J, Xiao Y, Zhou W, Wu Z, Zhang R, Xu T. | 05/3/2010 |
| SYTVII is expressed on insulin granules and only SYTVII alpha is implicated in exocytosis under physiological conditions | Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis.
Gauthier BR, Duhamel DL, Iezzi M, Theander S, Saltel F, Fukuda M, Wehrle-Haller B, Wollheim CB. | 01/21/2010 |
| Synaptotagmin VII functions as a high-affinity calcium sensor and is targeted to secretory organelles in rat tumor cells | Synaptotagmin VII is targeted to secretory organelles in PC12 cells, where it functions as a high-affinity calcium sensor.
Wang P, Chicka MC, Bhalla A, Richards DA, Chapman ER., Free PMC Article | 01/21/2010 |
| The cytoplasmic C2 domains in synaptotagmin VII contain unique internalization signals and regulators of these endocytotic signals. | Internalization signals in synaptotagmin VII utilizing two independent pathways are masked by intramolecular inhibitions.
Dasgupta S, Kelly RB. | 01/21/2010 |
| Alternative splicing of this protein acts as a molecular switch, which targets vesicles to fast and slow recycling pathways | Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling.
Virmani T, Han W, Liu X, Südhof TC, Kavalali ET., Free PMC Article | 01/21/2010 |
| Syt VII molecule on dense-core vesicles functions as a vesicular Ca2+ sensor for exocytosis in endocrine cells. | Synaptotagmin VII is targeted to dense-core vesicles and regulates their Ca2+ -dependent exocytosis in PC12 cells.
Fukuda M, Kanno E, Satoh M, Saegusa C, Yamamoto A. | 01/21/2010 |
| synaptotagmin VII-regulated lysosomal exocytosis involves the SNARE domains of syntaxin 4 and TI-VAMP/VAMP7 | Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis.
Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW. | 01/21/2010 |
| identified the conserved alternative splicing events in the spacer domain of Syt VII; also shown that Syt VIIa-GFP is mainly localized in the perinuclear region and tips of neurites (dense-core vesicles), and not in the plasma membrane | Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human.
Fukuda M, Ogata Y, Saegusa C, Kanno E, Mikoshiba K., Free PMC Article | 01/21/2010 |