| Histamine H1- and H4-receptor expression in human colon-derived cell lines. | Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines.
Schrammel JC, König M, Frommer M, Andersen KS, Kirsten M, Seifert R, Neumann D, Schirmer B., Free PMC Article | 03/21/2024 |
| Histamine-4 Receptor: Emerging Target for the Treatment of Neurological Diseases. | Histamine-4 Receptor: Emerging Target for the Treatment of Neurological Diseases.
Shan L, Martens GJM, Swaab DF. | 10/8/2022 |
| Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma. | Unraveling the venom chemistry with evidence for histamine as key regulator in the envenomation by caterpillar Automeris zaruma.
Seldeslachts A, Peigneur S, Mebs D, Tytgat J., Free PMC Article | 10/1/2022 |
| Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study. | Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study.
Speisky D, Táquez Delgado MA, Iotti A, Nicoud MB, Ospital IA, Vigovich F, Dezanzo P, Ernst G, Uriburu JL, Medina VA., Free PMC Article | 04/23/2022 |
| Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma. | Histamine H4 Receptor Agonism Induces Antitumor Effects in Human T-Cell Lymphoma.
Clauzure M, Táquez Delgado MA, Phillip JM, Revuelta MV, Cerchietti L, Medina VA., Free PMC Article | 03/12/2022 |
| Identification of TSPAN4 as Novel Histamine H4 Receptor Interactor. | Identification of TSPAN4 as Novel Histamine H(4) Receptor Interactor.
Ma X, Verweij EWE, Siderius M, Leurs R, Vischer HF., Free PMC Article | 09/25/2021 |
| Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. | Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
Nicoud MB, Sterle HA, Massari NA, Táquez Delgado MA, Formoso K, Herrero Ducloux MV, Martinel Lamas D, Cremaschi GA, Medina VA., Free PMC Article | 10/24/2020 |
| HRH4 rs77485247 polymorphism may be an important mediator in regulating proinflammatory cytokines | Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease.
Qin D, Zhang H, Wang J, Hong Z., Free PMC Article | 01/4/2020 |
| our present study confirmed the expression of H4R in ESCC, which was closely associated with clinicopathological features, including histological grades, primary tumor size, lymph node metastasis, and patient survival. | Activation of histamine H(4) receptor suppresses the proliferation and invasion of esophageal squamous cell carcinoma via both metabolism and non-metabolism signaling pathways.
He GH, Ding JQ, Zhang X, Xu WM, Lin XQ, Huang MJ, Feng J, Wang P, Cai WK. | 11/2/2019 |
| ur data indicate that the H4 peptide tail promotes the formation of active strand transfer complexes (STCs) and support an activation step of the incoming intasome at the contact of the histone tail. | Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase.
Mauro E, Lesbats P, Lapaillerie D, Chaignepain S, Maillot B, Oladosu O, Robert X, Fiorini F, Kieffer B, Bouaziz S, Gouet P, Ruff M, Parissi V., Free PMC Article | 10/12/2019 |
| these findings reveal that rs11662595 is a loss-of-function polymorphism that results in dysfunction of HRH4 and attenuates the anti-epithelial-to-mesenchymal transition function of HRH4 in non-small cell lung cancer (NSCLC), which provides a promising biomarker for prognosis and therapy of NSCLC. | The HRH4 rs11662595 mutation is associated with histamine H(4) receptor dysfunction and with increased epithelial-to-mesenchymal transition progress in non-small cell lung cancer.
Cai WK, Zhang JB, Chen JH, Meng JR, Ma X, Zhang J, Zhou YL, Xu GL, He GH. | 12/1/2018 |
| Taken together, the silencing of H4R inhibited the H4R mediated Mast cell functions and SAPK/JNK phosphorylation. Furthermore, the H4R activation utilized SAPK/JNK signaling pathway for IL-1beta release in HMC-1 cells | Silencing of H4R inhibits the production of IL-1β through SAPK/JNK signaling in human mast cells.
Ebenezer AJ, Prasad K, Rajan S, Thangam EB. | 10/27/2018 |
| Our novel scientific data provide further indication that histamine, in particular via the H4R, plays a potent role in the pathophysiology of allergic diseases through tight control of Th1-Th2 mediator production favoring Th2 lymphocyte accumulation in inflamed tissues. Our results add to a growing evidence of data suggesting that the H4R may serve as a therapeutic target in allergic diseases. | The histamine H4 receptor modulates the differentiation process of human monocyte-derived M1 macrophages and the release of CCL4/MIP-1β from fully differentiated M1 macrophages.
Mommert S, Ratz L, Stark H, Gutzmer R, Werfel T. | 09/29/2018 |
| The expression of H4R was increased in peripheral blood monocytes in rheumatoid arthritis patients. Histamine and Th17 cytokines induced the osteoclast differentiation from monocytes and JNJ7777120 decreased the osteoclastogenesis. | Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis.
Kim KW, Kim BM, Lee KA, Lee SH, Firestein GS, Kim HR., Free PMC Article | 09/8/2018 |
| H1R and H4R are useful biomarkers of allergic inflammation on the ocular surface. Most notably, H4R expressed on eosinophils is useful as a biomarker of eosinophilic inflammation of the ocular surface. | Histamine H(1) and H(4) receptor expression on the ocular surface of patients with chronic allergic conjunctival diseases.
Inada N, Shoji J, Shiraki Y, Aso H, Yamagami S. | 05/26/2018 |
| Histamine stimulation influences the IL-17 pathway in psoriasis via the fourth histamine receptor subtype, H4R, on CD4+ T cells. | Preliminary study of histamine H(4) receptor expressed on human CD4(+) T cells and its immunomodulatory potency in the IL-17 pathway of psoriasis.
Han SH, Hur MS, Kim MJ, Kim BM, Kim KW, Kim HR, Choe YB, Ahn KJ, Lee YW. | 05/26/2018 |
| This study suggests that genetic variations within the HRH4 gene might be associated with special clinical features of psoriasis. | Genetic variations within the promotor region of the human histamine H4 receptor gene in psoriasis patients.
Mommert S, Ratz L, Herwig K, Rost M, Gutzmer R, Werfel T. | 12/30/2017 |
| Our findings provide evidence that HRH4 rs77485247 and rs77041280 polymorphisms may be associated with the risk of allergic rhinitis (AR) and the efficacy of H1 antihistamines for the treatment of AR patients. | Histamine H4 receptor gene polymorphisms: a potential predictor of oral H1 antihistamine efficacy for allergic rhinitis.
Gu J, Mao XH, Yang XZ, Ao HF, Zhang Z, Li Y. | 12/9/2017 |
| These data imply that the H4R regulates IgE-dependent processes in human basophils and provides a novel function of the H4R preventing an overwhelming immune reaction by engagement of a negative feedback loop. | Human basophil chemotaxis and activation are regulated via the histamine H4 receptor.
Mommert S, Kleiner S, Gehring M, Eiz-Vesper B, Stark H, Gutzmer R, Werfel T, Raap U. | 11/25/2017 |
| Pharmacological or genetic modulations of H2 and H4 HRs (H2R and H4R) not only suppressed gefitinib-induced cytostasis and differentiation of AML cells but also blocked EGFR and ERK1/2 inhibition in MDA-MB-231 cells | Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors.
Yadav M, Singh AK, Kumar H, Rao G, Chakravarti B, Gurjar A, Dogra S, Kushwaha S, Vishwakarma AL, Yadav PN, Datta D, Tripathi AK, Chattopadhyay N, Trivedi AK, Sanyal S. | 11/4/2017 |
| Histamine H4 receptors could not be identified in five experimental models of the guinea-pig that are suited for the detection of presynaptic inhibitory receptors (hippocampus aorta, atrium, renal cortex and vas deferens) whereas H3 receptors could be shown in the peripheral tissues but not in the hippocampus | A search for presynaptic inhibitory histamine receptors in guinea-pig tissues: Further H3 receptors but no evidence for H4 receptors.
Petri D, Schlicker E. | 07/1/2017 |
| Taken together these data demonstrate that compound A and compound L may block H4R-mediated downstream signaling events. | Effect of H4R antagonist N-(2-aminoethyl)-5-chloro-1H-indol-2-carboxamides and 5-chloro-2-(piperazin-1-ylmethyl)-1H-benzimidazole on histamine and 4-methylhistamine-induced mast cell response.
Nagarajan G, Mariappanadar V, Tamizh M, Kaliappan I, Elden BT. | 06/10/2017 |
| We also found that the activation of H4R caused the release of IL-13 and RANTES on human mast cells.these data demonstrate that the H4R activates divergent signaling pathways to induce cytokine and chemokine production in human mast cells | H4R activation utilizes distinct signaling pathways for the production of RANTES and IL-13 in human mast cells.
Ebenezer AJ, Arunachalam P, Elden BT. | 05/20/2017 |
| H4R may be involved in the maintenance of healthy oral mucosa. In oral lichen planus, this maintenance might be impaired by mast cell degranulation and inflammatory cytokines. | Histamine H4 receptor in oral lichen planus.
Salem A, Al-Samadi A, Stegajev V, Stark H, Häyrinen-Immonen R, Ainola M, Hietanen J, Konttinen YT. | 12/17/2016 |
| Activation of the H4R could induce phosphorylation of ERK. | Histamine H4 Receptor mediates interleukin-8 and TNF-α release in human mast cells via multiple signaling pathways.
Chen XF, Zhang Z, Dou X, Li JJ, Zhang W, Yu YY, Yu B, Yu B. | 10/29/2016 |