| Disruption of DNA polymerase zeta engages an innate immune response. | Disruption of DNA polymerase ζ engages an innate immune response.
Martin SK, Tomida J, Wood RD., Free PMC Article | 01/29/2022 |
| The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. | The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
Adeyemi RO, Willis NA, Elia AEH, Clairmont C, Li S, Wu X, D'Andrea AD, Scully R, Elledge SJ., Free PMC Article | 01/8/2022 |
| REV1-Polzeta maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps. | REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.
Taglialatela A, Leuzzi G, Sannino V, Cuella-Martin R, Huang JW, Wu-Baer F, Baer R, Costanzo V, Ciccia A., Free PMC Article | 01/1/2022 |
| DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability. | DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability.
Ben Yamin B, Ahmed-Seghir S, Tomida J, Despras E, Pouvelle C, Yurchenko A, Goulas J, Corre R, Delacour Q, Droin N, Dessen P, Goidin D, Lange SS, Bhetawal S, Mitjavila-Garcia MT, Baldacci G, Nikolaev S, Cadoret JC, Wood RD, Kannouche PL., Free PMC Article | 12/18/2021 |
| REV3L single nucleotide variants lead to increased susceptibility towards non-small cell lung cancer in the population of Jammu and Kashmir. | REV3L single nucleotide variants lead to increased susceptibility towards non-small cell lung cancer in the population of Jammu and Kashmir.
Jamwal RS, Mahajan N, Bhat GR, Bhat A, Shah R, Verma S, Sharma M, Sharma B, Qadri RA, Kumar R, Bhat A. | 12/18/2021 |
| Developmental delay with hypotrophy associated with homozygous functionally relevant REV3L variant. | Developmental delay with hypotrophy associated with homozygous functionally relevant REV3L variant.
Halas A, Fijak-Moskal J, Kuberska R, Murcia Pienkowski V, Kaniak-Golik A, Pollak A, Poznanski J, Rydzanicz M, Bik-Multanowski M, Sledziewska-Gojska E, Płoski R. | 12/11/2021 |
| Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells. | Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells.
Suzuki T, Sassa A, Grúz P, Gupta RC, Johnson F, Adachi N, Nohmi T. | 08/14/2021 |
| Translesion synthesis of 6-nitrochrysene-derived 2'-deoxyadenosine adduct in human cells. | Translesion synthesis of 6-nitrochrysene-derived 2'-deoxyadenosine adduct in human cells.
Powell BV, Bacurio JHT, Basu AK., Free PMC Article | 04/3/2021 |
| Blood mRNA expression of REV3L and TYMS as potential predictive biomarkers from platinum-based chemotherapy plus pemetrexed in non-small cell lung cancer patients. | Blood mRNA expression of REV3L and TYMS as potential predictive biomarkers from platinum-based chemotherapy plus pemetrexed in non-small cell lung cancer patients.
Agulló-Ortuño MT, García-Ruiz I, Díaz-García CV, Enguita AB, Pardo-Marqués V, Prieto-García E, Ponce S, Iglesias L, Zugazagoitia J, López-Martín JA, Paz-Ares L, Nuñez JA. | 11/21/2020 |
| Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain. | Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain.
Huang F, Tanaka H, Knudsen BS, Rutgers JK., Free PMC Article | 11/21/2020 |
| A post-translational cleavage event plays a vital role in controlling REV3L stability by preventing ubiquitination and proteasome-mediated degradation of REV3L | Site-specific proteolytic cleavage prevents ubiquitination and degradation of human REV3L, the catalytic subunit of DNA polymerase ζ.
Wang F, Li P, Shao Y, Li Y, Zhang K, Li M, Wang R, Zheng S, Wang Y, Song S, Feng S, Liu F, Xiao W, Li X., Free PMC Article | 07/11/2020 |
| miR-145 was downregulated in esophageal squamous cell carcinoma (ESCC) tumor tissues and cells, while REV3L was upregulated in ESCC tumor tissues. Overexpression of miR-145 decreased REV3L mRNA and protein level in ESCC cell line KYSE150, while decreased miR-145 increased REV3L mRNA and protein level in esophageal epithelium cell line (HEEC). | miR-145 Regulates the sensitivity of esophageal squamous cell carcinoma cells to 5-FU via targeting REV3L.
Chen Q, Hou J, Wu Z, Zhao J, Ma D. | 01/18/2020 |
| The roles of POLZ in DNA replication and repair have been summarized. (Review) | DNA polymerase ζ in DNA replication and repair.
Martin SK, Wood RD., Free PMC Article | 12/14/2019 |
| These data provide a model whereby interbase H-bonding interactions at the DNA terminus promote lesion bypass and extension by human DNA polymerase zeta. | Hydrogen-Bonding Interactions at the DNA Terminus Promote Extension from Methylguanine Lesions by Human Extender DNA Polymerase ζ.
Räz MH, Sturla SJ, Gahlon HL. | 07/20/2019 |
| Results suggest a pivotal role of miR29a in mediating NSCLC cell sensitivity towards cisplatin through the regulation of REV3L. | MicroRNA‑29a enhances cisplatin sensitivity in non‑small cell lung cancer through the regulation of REV3L.
Chen X, Zhu H, Ye W, Cui Y, Chen M., Free PMC Article | 06/1/2019 |
| We have identified and characterised a novel DNA damage response mechanism in melanoma. Instead of increasing levels of RAD51 on encountering cisplatin-induced interstrand crosslinks during replication, melanoma cells shut down RAD51 synthesis and instead boost levels of translesion synthesis DNA polymerase zeta to allow replication to proceed | Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ζ.
Song L, McNeil EM, Ritchie AM, Astell KR, Gourley C, Melton DW., Free PMC Article | 07/28/2018 |
| Following challenge with AFB1, survival of mouse cells deficient in pol zeta (Rev3L(-/-)) was significantly reduced relative to Rev3L(+/-) cells or Rev3L(-/-) cells complemented through expression of the wild-type human REV3L | DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.
Lin YC, Owen N, Minko IG, Lange SS, Tomida J, Li L, Stone MP, Wood RD, McCullough AK, Lloyd RS., Free PMC Article | 03/31/2018 |
| These results demonstrate a previously unrecognized relationship between p53 and REV3L in cancer cell metabolism and may lead to improvements in chemotherapy treatment plans that reduce cisplatin resistance in lung cancer. | Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells.
Kong L, Murata MM, Digman MA., Free PMC Article | 02/17/2018 |
| REV3/ATR knockdown enhances the cytotoxicity of cisplatin in non-small cell lung cells. | Knockdown of REV3 synergizes with ATR inhibition to promote apoptosis induced by cisplatin in lung cancer cells.
Jiang HG, Chen P, Su JY, Wu M, Qian H, Wang Y, Li J. | 10/7/2017 |
| The data directly show that, in the human genome, DNA Pol-eta and Rev1 bypass cyclobutane pyrimidine dimers and 6-4PP at replication forks, while only 6-4PP are also tolerated by a Rev3L-dependent gap-filling mechanism, independent of S phase. | Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.
Quinet A, Martins DJ, Vessoni AT, Biard D, Sarasin A, Stary A, Menck CF., Free PMC Article | 06/10/2017 |
| The results indicate that human DNA polymerase zeta plays important roles in induction of mutations, clastogenicity and in cellular survival of the damaged human cells. | Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase ζ to genotoxic stresses.
Suzuki T, Grúz P, Honma M, Adachi N, Nohmi T. | 05/20/2017 |
| loss-of-function of REV3L dramatically enhanced the sensitivity of SCCHN cells to dacomitinib by the loss of both translesion synthesis and homologous recombination pathways. | Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck.
Huang KK, Jang KW, Kim S, Kim HS, Kim SM, Kwon HJ, Kim HR, Yun HJ, Ahn MJ, Park KU, Ramnarayanan K, McPherson JR, Zhang S, Rhee JK, Vettore AL, Das K, Ishimoto T, Kim JH, Koh YW, Kim SH, Choi EC, Teh BT, Rozen SG, Kim TM, Tan P, Cho BC., Free PMC Article | 01/14/2017 |
| REV3L plays an important role in esophageal squamous cell carcinoma (ESCC) progression and chemoresistance, and is a potential diagnostic marker and therapeutic target for ESCC | REV3L, the catalytic subunit of DNA polymerase ζ, is involved in the progression and chemoresistance of esophageal squamous cell carcinoma.
Zhu X, Zou S, Zhou J, Zhu H, Zhang S, Shang Z, Ding WQ, Wu J, Chen Y. | 10/29/2016 |
| REV3 functions in mammalian mitochondria and that mitochondrial REV3 is associated with the tumorigenic potential of cells. | Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome.
Singh B, Li X, Owens KM, Vanniarajan A, Liang P, Singh KK., Free PMC Article | 06/11/2016 |
| Taken together, we demonstrated that inhibition of REV3L sensitized lung cancer H1299 cells to cisplatin treatment | REV3L modulates cisplatin sensitivity of non-small cell lung cancer H1299 cells.
Wang W, Sheng W, Yu C, Cao J, Zhou J, Wu J, Zhang H, Zhang S. | 05/14/2016 |