| RPA3 promotes the proliferation, migration, and invasion of gliomas by activating the PI3K-AKT-mTOR pathway. | RPA3 promotes the proliferation, migration, and invasion of gliomas by activating the PI3K-AKT-mTOR pathway.
Liang L, Zhao Z, Jin Q, Zhang S, Zhao Z, Li X. | 08/14/2023 |
| Knockdown of replication protein A 3 induces protective autophagy and enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting AKT/mTOR signaling via binding to cyclin-dependent kinases regulatory subunit 2. | Knockdown of replication protein A 3 induces protective autophagy and enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting AKT/mTOR signaling via binding to cyclin-dependent kinases regulatory subunit 2.
Chen L, Hu K, Liu Y, Liu L, Tang J, Qin X. | 12/3/2022 |
| Overexpression of replication protein A3 is associated with unfavorable outcome in bladder urothelial carcinoma. | Overexpression of replication protein A3 is associated with unfavorable outcome in bladder urothelial carcinoma.
Sun D, Zhang K, Fu Q, Zhang H, Liu S, Wang H, Xu Z, Wang J. | 12/11/2021 |
| Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair. | Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair.
Caldwell CC, Spies M., Free PMC Article | 03/13/2021 |
| Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis. | Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis.
Pelsma ICM, Claessen KMJA, Slagboom PE, van Heemst D, Pereira AM, Kroon HM, Ramos YFM, Kloppenburg M, Biermasz NR, Meulenbelt IM. | 12/5/2020 |
| A four-gene signature in the tumor microenvironment that significantly associates with the prognosis of patients with breast cancer. | A four-gene signature in the tumor microenvironment that significantly associates with the prognosis of patients with breast cancer.
Wang J, Yang Z, Zhang C, Ouyang J, Zhang G, Wu C. | 10/10/2020 |
| MiR-146a-5p could lead to the restriction of proliferation and the promotion of radiosensitivity and apoptosis in HCC cells through activation of DNA repair pathway and inhibition of RPA3. | MicroRNA-146a-5p enhances radiosensitivity in hepatocellular carcinoma through replication protein A3-induced activation of the DNA repair pathway.
Luo J, Si ZZ, Li T, Li JQ, Zhang ZQ, Chen GS, Qi HZ, Yao HL. | 01/11/2020 |
| RPA3 is a potential marker of prognosis, radioresistance and survival in nasopharyngeal carcinoma. | RPA3 is a potential marker of prognosis and radioresistance for nasopharyngeal carcinoma.
Qu C, Zhao Y, Feng G, Chen C, Tao Y, Zhou S, Liu S, Chang H, Zeng M, Xia Y., Free PMC Article | 06/16/2018 |
| Up-regulation of RPA3 is involved in gastric cancer tumorigenesis and is associated with poorer patient survival. | Elevated Expression of RPA3 Is Involved in Gastric Cancer Tumorigenesis and Associated with Poor Patient Survival.
Dai Z, Wang S, Zhang W, Yang Y. | 12/9/2017 |
| RPA, best known for its role in DNA replication and repair, recruits HIRA to promoters and enhancers and regulates deposition of newly synthesized H3.3 to these regulatory elements for gene regulation. | RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.
Zhang H, Gan H, Wang Z, Lee JH, Zhou H, Ordog T, Wold MS, Ljungman M, Zhang Z., Free PMC Article | 10/7/2017 |
| The allele "T" of rs6947203 in the RPA3 gene acts as a protective allele in glioma. | TP53 and RPA3 gene variations were associated with risk of glioma in a Chinese Han population.
Jin T, Zhang J, Li G, Li S, Yang B, Chen C, Cai L. | 02/15/2014 |
| Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified. | Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3.
Ali G, Lee K, Andrade PB, Basit S, Santos-Cortez RL, Chen L, Jelani M, Ansar M, Ahmad W, Leal SM., Free PMC Article | 01/28/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | XPC genetic polymorphisms correlate with the response to imatinib treatment in patients with chronic phase chronic myeloid leukemia.
Guillem VM, Cervantes F, Martínez J, Alvarez-Larrán A, Collado M, Camós M, Sureda A, Maffioli M, Marugán I, Hernández-Boluda JC. | 09/15/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J., Free PMC Article | 06/30/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. | 04/7/2010 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S. | 03/25/2009 |
| RPA3 interacts directly with ssDNA on the 3'-side on a 31 nt ssDNA. | Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA.
Salas TR, Petruseva I, Lavrik O, Saintomé C., Free PMC Article | 01/21/2010 |
| Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | Comprehensive analysis of DNA repair gene variants and risk of meningioma.
Bethke L, Murray A, Webb E, Schoemaker M, Muir K, McKinney P, Hepworth S, Dimitropoulou P, Lophatananon A, Feychting M, Lönn S, Ahlbom A, Malmer B, Henriksson R, Auvinen A, Kiuru A, Salminen T, Johansen C, Christensen HC, Kosteljanetz M, Swerdlow A, Houlston R. | 04/3/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesVariation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium. Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.
Michiels S, Danoy P, Dessen P, Bera A, Boulet T, Bouchardy C, Lathrop M, Sarasin A, Benhamou S. | 03/13/2008 |