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    RPS15A ribosomal protein S15a [ Homo sapiens (human) ]

    Gene ID: 6210, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A.

    MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A.
    Natani S, Ramakrishna M, Nallavolu T, Ummanni R.

    05/28/2023
    FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.

    FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.
    Yang H, Li M, Qi Y.

    05/5/2023
    Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1.

    Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1.
    Wan BS, Wang XY, Tiang J, Zhou C, Lin J, Wang Z.

    03/12/2022
    MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/beta-catenin signalling via targeting of RPS15A.

    MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/β-catenin signalling via targeting of RPS15A.
    Ning Q, Pang Y, Shao S, Luo M, Zhao L, Hu T, Zhao X.

    05/8/2021
    Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1.

    Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1.
    Kong L, Wei Q, Hu X, Chen L, Li J.

    03/20/2021
    Ribosomal protein S15a (RPS15A) is up-regulated in gastric cancer (GC) patients and associated with poor prognosis.

    RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway.
    Liu C, He X, Liu X, Yu J, Zhang M, Yu F, Wang Y., Free PMC Article

    07/11/2020
    miR-29a-3p inhibits CRC cell function possibly by targeting RPS15A

    Downregulation of RPS15A by miR-29a-3p attenuates cell proliferation in colorectal carcinoma.
    Zheng Z, Cui H, Wang Y, Yao W.

    01/11/2020
    A preliminary experimental basis for RPS15A as a novel oncogene and potential therapeutic target in RCC.

    Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo.
    Liang J, Liu Z, Zou Z, Wang X, Tang Y, Zhou C, Wu K, Zhang F, Lu Y., Free PMC Article

    06/1/2019
    The present study found RPS15a expression to be higher in gastric tumors and its silencing in gastric cancer cells to inhibit the proliferation, growth, and migration thereof. Accordingly, RPS15a may be considered as a potential therapeutic target in gastric cancer.

    RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer.
    Shi D, Liu J., Free PMC Article

    03/23/2019
    High RPS15A expression is associated with angiogenesis in hepatocellular carcinoma.

    Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma.
    Guo P, Wang Y, Dai C, Tao C, Wu F, Xie X, Yu H, Zhu Q, Li J, Ye L, Yu F, Shan Y, Yu Z, Dhanasekaran R, Zheng R, Chen G.

    03/9/2019
    RPS15A is a novel causative gene for Diamond-Blackfan anemia.

    Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia.
    Ikeda F, Yoshida K, Toki T, Uechi T, Ishida S, Nakajima Y, Sasahara Y, Okuno Y, Kanezaki R, Terui K, Kamio T, Kobayashi A, Fujita T, Sato-Otsubo A, Shiraishi Y, Tanaka H, Chiba K, Muramatsu H, Kanno H, Ohga S, Ohara A, Kojima S, Kenmochi N, Miyano S, Ogawa S, Ito E., Free PMC Article

    08/11/2018
    Our findings indicate that RPS15A promotes cell proliferation and migration in glioblastoma for the first time. RPS15A might play a distinct role in glioblastoma and serve as a potential target for therapy

    Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway.
    Yao Y, Liu Y, Lv X, Dong B, Wang F, Li J, Zhang Q, Xu R, Xu Y.

    02/18/2017
    the present study provides novel evidence indicating that RPS15A modulates AML cell growth in vitro, and may be considered a novel therapeutic target for the treatment of AML.

    shRNA-mediated RPS15A silencing inhibits U937 acute myeloid leukemia cell proliferation and enhances apoptosis.
    Li G, Zhang L, Liu J, Xiao T, Liu G, Wang J, Hou M.

    02/18/2017
    High RPS15A expression is associated with glioblastoma.

    Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis.
    Zhang C, Fu J, Xue F, Ryu B, Zhang T, Zhang S, Sun J, Xu X, Shen Z, Zheng L, Chen X., Free PMC Article

    01/14/2017
    Results show that RPS15A is overexpressed in colorectal cancer (CRC) tissue and predicts a worse prognosis and outcome of CRC patients through misregulation of cell cycle progression and promotion of metastasis.

    Ribosomal protein S15A promotes malignant transformation and predicts poor outcome in colorectal cancer through misregulation of p53 signaling pathway.
    Chen J, Wei Y, Feng Q, Ren L, He G, Chang W, Zhu D, Yi T, Lin Q, Tang W, Xu J, Qin X.

    12/31/2016
    we identify RPS15A as a novel potential oncogenic gene involved in lung carcinogenesis.

    Decreased expression of RPS15A suppresses proliferation of lung cancer cells.
    Zhao X, Shen L, Feng Y, Yu H, Wu X, Chang J, Shen X, Qiao J, Wang J.

    03/5/2016
    RPS15A may play a prominent role in heptocarcinogenesis and serve as a potential therapeutic target in hepatocellular carcinoma.

    Down-regulation of ribosomal protein S15A mRNA with a short hairpin RNA inhibits human hepatic cancer cell growth in vitro.
    Xu M, Wang Y, Chen L, Pan B, Chen F, Fang Y, Yu Z, Chen G.

    03/8/2014
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