| Rare Variants in Genes Encoding Subunits of the Epithelial Na[+] Channel Are Associated With Blood Pressure and Kidney Function. | Rare Variants in Genes Encoding Subunits of the Epithelial Na(+) Channel Are Associated With Blood Pressure and Kidney Function.
Blobner BM, Kirabo A, Kashlan OB, Sheng S, Arnett DK, Becker LC, Boerwinkle E, Carlson JC, Gao Y, Gibbs RA, He J, Irvin MR, Kardia SLR, Kelly TN, Kooperberg C, McGarvey ST, Menon VK, Montasser ME, Naseri T, Redline S, Reiner AP, Reupena MS, Smith JA, Sun X, Vaidya D, Viaud-Martinez KA, Weeks DE, Yanek LR, Zhu X, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium*, Minster RL, Kleyman TR., Free PMC Article | 01/28/2023 |
| CRISPR/Cas9 Mediated Knock Down of delta-ENaC Blunted the TNF-Induced Activation of ENaC in A549 Cells. | CRISPR/Cas9 Mediated Knock Down of δ-ENaC Blunted the TNF-Induced Activation of ENaC in A549 Cells.
Shabbir W, Topcagic N, Aufy M, Oz M., Free PMC Article | 04/17/2021 |
| Proliferative regulation of alveolar epithelial type 2 progenitor cells by human Scnn1d gene. | Proliferative regulation of alveolar epithelial type 2 progenitor cells by human Scnn1d gene.
Zhao R, Ali G, Chang J, Komatsu S, Tsukasaki Y, Nie HG, Chang Y, Zhang M, Liu Y, Jain K, Jung BG, Samten B, Jiang D, Liang J, Ikebe M, Matthay MA, Ji HL., Free PMC Article | 08/29/2020 |
| The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations | The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations.
Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C., Free PMC Article | 12/9/2017 |
| deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP. | δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in Xenopus laevis oocytes.
Rauh R, Hoerner C, Korbmacher C. | 06/24/2017 |
| delta-ENaC expression is low in NCI-H441, Calu-3, and ATI cells and does not contribute to transepithelial sodium absorption | Expression and function of the epithelial sodium channel δ-subunit in human respiratory epithelial cells in vitro.
Schwagerus E, Sladek S, Buckley ST, Armas-Capote N, Alvarez de la Rosa D, Harvey BJ, Fischer H, Illek B, Huwer H, Schneider-Daum N, Lehr CM, Ehrhardt C. | 07/30/2016 |
| study characterized a new variant, delta2 ENaC, in lung epithelial cells; heterologous delta2betagamma ENaC exhibited a number of divergent features from the delta1betagamma counterpart in biophysics and pharmacology, regulation, and the lifespan of proteins | Characterization of a novel splice variant of δ ENaC subunit in human lungs.
Zhao RZ, Nie HG, Su XF, Han DY, Lee A, Huang Y, Chang Y, Matalon S, Ji HL., Free PMC Article | 11/24/2012 |
| delta-ENaC undergoes dynamin-independent endocytosis as opposed to alphabetagamma-channels. | Differential N termini in epithelial Na+ channel δ-subunit isoforms modulate channel trafficking to the membrane.
Wesch D, Althaus M, Miranda P, Cruz-Muros I, Fronius M, González-Hernández T, Clauss WG, Alvarez de la Rosa D, Giraldez T. | 05/19/2012 |
| These results suggest that COMMD1 downregulates deltaENaC activity by reducing deltaENaC surface expression through promoting internalization of surface deltaENaC to an intracellular recycling pool, possibly via enhanced ubiquitination. | COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination.
Chang T, Ke Y, Ly K, McDonald FJ. | 10/1/2011 |
| Identify the specific domains of epithelial sodium channels that are responsible for the differences in the response to flow of alphabetagamma and deltabetagamma channels. | Second transmembrane domain modulates epithelial sodium channel gating in response to shear stress.
Abi-Antoun T, Shi S, Tolino LA, Kleyman TR, Carattino MD., Free PMC Article | 07/2/2011 |
| CPT-cGMP Stimulates Human Alveolar Fluid Clearance by Releasing External Na+ Self-Inhibition of ENaC. | 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channels.
Han DY, Nie HG, Su XF, Shi XM, Bhattarai D, Zhao M, Zhao RZ, Landers K, Tang H, Zhang L, Ji HL., Free PMC Article | 05/23/2011 |
| Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition. | Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition.
Molina R, Han DY, Su XF, Zhao RZ, Zhao M, Sharp GM, Chang Y, Ji HL., Free PMC Article | 05/23/2011 |
| Data support a physiological role for SGK1.1 in the regulation of delta-ENaC through a pathway that differs from the classical one and suggest that the kinase could serve as an integrator of different signaling pathways converging on the channel. | The neuronal-specific SGK1.1 kinase regulates {delta}-epithelial Na+ channel independently of PY motifs and couples it to phospholipase C signaling.
Wesch D, Miranda P, Afonso-Oramas D, Althaus M, Castro-Hernández J, Dominguez J, Morty RE, Clauss W, González-Hernández T, Alvarez de la Rosa D, Giraldez T. | 10/30/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| the delta-subunit of ENaC alters proteolytic channel activation and enhances base-line channel activity | The delta-subunit of the epithelial sodium channel (ENaC) enhances channel activity and alters proteolytic ENaC activation.
Haerteis S, Krueger B, Korbmacher C, Rauh R., Free PMC Article | 01/21/2010 |
| EIPA [5-(N-ethyl-N-isopropyl)-amiloride hydrochloride] inhibition of ENaCs, possibly ENaC-alpha and ENaC-delta, significantly improved the sperm motility in healthy donors and in asthenospermia patients. | Blockade of epithelial sodium channels improves sperm motility in asthenospermia patients.
Kong XB, Ma HG, Li HG, Xiong CL. | 01/21/2010 |
| Regulation of epithelial sodium channels by cGMP/PKGII. | Regulation of epithelial sodium channels by cGMP/PKGII.
Nie HG, Chen L, Han DY, Li J, Song WF, Wei SP, Fang XH, Gu X, Matalon S, Ji HL., Free PMC Article | 01/21/2010 |
| ENaCdelta is a candidate molecule for pH sensing in the gastrointestinal system in humans, providing a novel therapeutic target for gastro-oesophageal reflux disease | Epithelial Na+ channel delta subunit is an acid sensor in the human oesophagus.
Yamamura H, Ugawa S, Ueda T, Nagao M, Joh T, Shimada S. | 01/21/2010 |
| Expression analyses at the level of mRNA clearly revealed that ENaC delta transcript was strongly expressed in human melanoma cells using reverse transcription-polymerase chain reaction and cell-based in situ hybridization techniques. | Expression analysis of the epithelial Na+ channel delta subunit in human melanoma G-361 cells.
Yamamura H, Ugawa S, Ueda T, Shimada S. | 01/21/2010 |
| ENaC delta isoforms are widely expressed in pyramidal cells of the human and monkey cerebral cortex and in different neuronal populations of telencephalic subcortical nuclei. | Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon.
Giraldez T, Afonso-Oramas D, Cruz-Muros I, Garcia-Marin V, Pagel P, González-Hernández T, Alvarez de la Rosa D. | 01/21/2010 |
| ENaCdelta activity is regulated by protons, and may contribute to the pH sensation and/or pH regulation in the human brain | Protons activate the delta-subunit of the epithelial Na+ channel in humans.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. | 01/21/2010 |
| delta ENaC is regulated by Murr1 | Identification of Murr1 as a regulator of the human delta epithelial sodium channel.
Biasio W, Chang T, McIntosh CJ, McDonald FJ. | 01/21/2010 |
| ENaCdelta is chemically activated by capsazepine by a proton-dependent mechanism | Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. | 01/21/2010 |
| analysis of anovel spliced variant of the ENaC delta-subunit in the human brain | A novel spliced variant of the epithelial Na+ channel delta-subunit in the human brain.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. | 01/21/2010 |