| The Prognostic Role of Serine Racemase in Patients With Pancreatic Cancer: A New Marker in Cancer Metabolism. | The Prognostic Role of Serine Racemase in Patients With Pancreatic Cancer: A New Marker in Cancer Metabolism.
Lan C, Yamashita YI, Tsukamoto M, Hayashi H, Nakagawa S, Liu Z, Wu X, Imai K, Mima K, Kaida T, Baba H. | 08/3/2023 |
| qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus. | qPCR Analysis Reveals Association of Differential Expression of SRR, NFKB1, and PDE4B Genes With Type 2 Diabetes Mellitus.
Raza W, Guo J, Qadir MI, Bai B, Muhammad SA., Free PMC Article | 03/5/2022 |
| The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase. | The allosteric interplay between S-nitrosylation and glycine binding controls the activity of human serine racemase.
Marchesani F, Gianquinto E, Autiero I, Michielon A, Campanini B, Faggiano S, Bettati S, Mozzarelli A, Spyrakis F, Bruno S. | 07/24/2021 |
| Human serine racemase is inhibited by glyceraldehyde 3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase. | Human serine racemase is inhibited by glyceraldehyde 3-phosphate, but not by glyceraldehyde 3-phosphate dehydrogenase.
Michielon A, Marchesani F, Faggiano S, Giaccari R, Campanini B, Bettati S, Mozzarelli A, Bruno S. | 04/17/2021 |
| Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients. | Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients.
Nickels SL, Walter J, Bolognin S, Gérard D, Jaeger C, Qing X, Tisserand J, Jarazo J, Hemmer K, Harms A, Halder R, Lucarelli P, Berger E, Antony PMA, Glaab E, Hankemeier T, Klein C, Sauter T, Sinkkonen L, Schwamborn JC. | 08/29/2020 |
| these findings suggest that d-serine expressed particularly strongly in atopic dermatitis lesional skin and that the Serine racemase (SR) expression in the keratinocytes is linked to inflammatory cytokines. | Inflammatory cytokine-mediated induction of serine racemase in atopic dermatitis.
Yoshihisa Y, Rehman MU, Nakagawa M, Matsukuma S, Makino T, Mori H, Shimizu T., Free PMC Article | 11/30/2019 |
| Results indicate glutamine 89 (Q89) as a key residue for the allosteric communication, since its mutation is linked to the loss of control of activity by nucleotides. | Glutamine 89 is a key residue in the allosteric modulation of human serine racemase activity by ATP.
Canosa AV, Faggiano S, Marchetti M, Armao S, Bettati S, Bruno S, Percudani R, Campanini B, Mozzarelli A., Free PMC Article | 10/26/2019 |
| SRR intronic variation inhibits expression of its neighboring SMG6 gene and protects against temporal lobe epilepsy. | SRR intronic variation inhibits expression of its neighbouring SMG6 gene and protects against temporal lobe epilepsy.
Tao H, Zhou X, Xie Q, Ma Z, Sun F, Cui L, Cai Y, Ma G, Fu J, Liu Z, Li Y, Zhou H, Zhao J, Chen Y, Mai H, Chen Y, Chen J, Qi W, Sun C, Zhao B, Li K., Free PMC Article | 10/19/2019 |
| SRR single nucleotide polymorphism, rs4523957, is associated with posttraumatic stress disorder. | Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning.
Balu DT, Presti KT, Huang CCY, Muszynski K, Radzishevsky I, Wolosker H, Guffanti G, Ressler KJ, Coyle JT., Free PMC Article | 05/4/2019 |
| SRR was identified as a type 2 diabetes susceptibility gene. SRR plays a role in insulin secretion in vitro. | Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.
Ndiaye FK, Ortalli A, Canouil M, Huyvaert M, Salazar-Cardozo C, Lecoeur C, Verbanck M, Pawlowski V, Boutry R, Durand E, Rabearivelo I, Sand O, Marselli L, Kerr-Conte J, Chandra V, Scharfmann R, Poulain-Godefroy O, Marchetti P, Pattou F, Abderrahmani A, Froguel P, Bonnefond A., Free PMC Article | 12/22/2018 |
| rs391300 SNP, located on the serine racemase (SRR) gene and linked to increased susceptibility to type 2 diabetes, was associated with progression from mild cognitive impairment to probable Alzheimer's disease. | Faster progression from MCI to probable AD for carriers of a single-nucleotide polymorphism associated with type 2 diabetes.
Girard H, Potvin O, Nugent S, Dallaire-Théroux C, Cunnane S, Duchesne S, Alzheimer's Disease Neuroimaging Initiative. | 09/29/2018 |
| Study found an inverse association between the genetic risk off schizophrenia based on 108 genome-wide significantly associated SNPs and the prevalence for treated migraine in a general population sample. This association was primary linked to SNPs associated with genes encoding proteins involved in glutamatergic neurotransmission and could be attributed to the single intronic variant rs4523957 in SRR. | The inverse link between genetic risk for schizophrenia and migraine through NMDA (N-methyl-D-aspartate) receptor activation via D-serine.
Van der Auwera S, Teumer A, Hertel J, Homuth G, Völker U, Lucht MJ, Degenhardt F, Schulze T, Rietschel M, Nöthen MM, John U, Nauck M, Grabe HJ. | 01/20/2018 |
| Data suggest that Ser-84 and Arg-135 are important in catalysis and substrate specificity of SRR. | Human serine racemase structure/activity relationship studies provide mechanistic insight and point to position 84 as a hot spot for β-elimination function.
Nelson DL, Applegate GA, Beio ML, Graham DL, Berkowitz DB., Free PMC Article | 09/16/2017 |
| Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form | Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form.
Bruno S, Margiotta M, Marchesani F, Paredi G, Orlandi V, Faggiano S, Ronda L, Campanini B, Mozzarelli A. | 08/19/2017 |
| MiR-193a-3p and miR-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma | MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively.
Pu Y, Zhao F, Cai W, Meng X, Li Y, Cai S., Free PMC Article | 08/6/2016 |
| Loss-of-function mutation of the gene encoding serine racemase significantly attenuates excitotoxicity in retina. | Loss-of-function mutation of serine racemase attenuates excitotoxicity by intravitreal injection of N-methyl-D-aspartate.
Jiang H, Wang X, Zhang H, Chang Y, Feng M, Wu S. | 04/30/2016 |
| Serine racemase activity and dynamics are regulated by halides, ATP and malonate. | Regulation of human serine racemase activity and dynamics by halides, ATP and malonate.
Marchetti M, Bruno S, Campanini B, Bettati S, Peracchi A, Mozzarelli A. | 10/3/2015 |
| In serine racemase, similarly to the related enzyme alanine racemase, the unprotonated pyridoxal-5'-phosphate -substrate intermediate is stabilized mostly due to solvation effects contributed by water molecules and active-site residues. | Understanding the reaction mechanism and intermediate stabilization in mammalian serine racemase using multiscale quantum-classical simulations.
Nitoker N, Major DT. | 04/11/2015 |
| FBXO22 protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase, activating it, and preventing its targeting to membranes. | FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.
Dikopoltsev E, Foltyn VN, Zehl M, Jensen ON, Mori H, Radzishevsky I, Wolosker H., Free PMC Article | 03/7/2015 |
| cross-talk between allosteric and active sites, leading to the stabilization of two alternative protein conformations with ATP affinities of ~ 10 muM and 1.8 mm | ATP binding to human serine racemase is cooperative and modulated by glycine.
Marchetti M, Bruno S, Campanini B, Peracchi A, Mai N, Mozzarelli A. | 12/28/2013 |
| S84A serine racemase mutant behaved like serine dehydratase, whereas A65S serine dehydratase mutant acquired an additional function of using D-serine as a substrate. | Modulating the function of human serine racemase and human serine dehydratase by protein engineering.
Wang CY, Ku SC, Lee CC, Wang AH. | 04/6/2013 |
| Six SNP(rs7754840 in CDKAL1, rs391300 in SRR, rs2383208 in CDKN2A/2B, rs4402960 in IGF2BP2, rs10830963 in MTNR1B, rs4607517 in GCK)risk alleles of type 2 diabetes were associated with GDM in pregnant Chinese women. | Association of six single nucleotide polymorphisms with gestational diabetes mellitus in a Chinese population.
Wang Y, Nie M, Li W, Ping F, Hu Y, Ma L, Gao J, Liu J., Free PMC Article | 04/14/2012 |
| The structural characteristics of SR obtained from live cells suggest that SR is sensitive to oxidation in vivo, perhaps consistent with a scenario in which such modification plays a role in feedback or other forms of regulation. | Roles of quaternary structure and cysteine residues in the activity of human serine racemase.
Wang W, Barger SW., Free PMC Article | 03/17/2012 |
| Serine racemase and D-serine are involved in both pre-symptomatic and progressive phases of amyotrophic lateral sclerosis, demonstrating a link between mutant superoxide dismutase (SOD)1 and a glial-derived toxic mediator in transgenic mice. | Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.
Thompson M, Marecki JC, Marinesco S, Labrie V, Roder JC, Barger SW, Crow JP., Free PMC Article | 03/10/2012 |
| The SRR mRNA is elevated in people death with suicide. | Elevated PICK1 mRNA in schizophrenia increased SRR mRNA in suicide.
Sarras H, Semeralul MO, Fadel MP, Feldcamp LA, Labrie V, Wong AH. | 10/23/2010 |