| An Epilepsy-Associated SV2A Mutation Disrupts Synaptotagmin-1 Expression and Activity-Dependent Trafficking. | An Epilepsy-Associated SV2A Mutation Disrupts Synaptotagmin-1 Expression and Activity-Dependent Trafficking.
Harper CB, Small C, Davenport EC, Low DW, Smillie KJ, Martínez-Mármol R, Meunier FA, Cousin MA., Free PMC Article | 10/24/2020 |
| This study reveals fundamental details of how phosphorylation of Thr84 on SV2A controls its interaction with synaptotagmin-1 and implicates SV2A as a phospho-dependent chaperone | Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.
Zhang N, Gordon SL, Fritsch MJ, Esoof N, Campbell DG, Gourlay R, Velupillai S, Macartney T, Peggie M, van Aalten DM, Cousin MA, Alessi DR., Free PMC Article | 04/18/2015 |
| observed alterations of SV2A expression in hippocampus are consistent with the hypothesis that SV2A absence favors epileptic seizures around postnatal day 7 | Expression of SV2 isoforms during rodent brain development.
Crèvecœur J, Foerch P, Doupagne M, Thielen C, Vandenplas C, Moonen G, Deprez M, Rogister B., Free PMC Article | 04/12/2014 |
| Action potential- and Ca(2+) -dependent glutamatergic & GABAergic synaptic transmission are differentially altered in the hippocampus of SV2A-deficient mice, but the mechanism of exocytosis itself is not changed. | Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice.
Venkatesan K, Alix P, Marquet A, Doupagne M, Niespodziany I, Rogister B, Seutin V. | 04/13/2013 |
| Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles. | Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles.
Kwon SE, Chapman ER., Free PMC Article | 01/5/2013 |
| study suggests that SV2A specifically regulates hilar GABAergic neurotransmission in the kindled hippocampus probably as a compensatory or prophylactic mechanism against kindling epileptogenesis | Kindling-associated SV2A expression in hilar GABAergic interneurons of the mouse dentate gyrus.
Ohno Y, Okumura T, Terada R, Ishihara S, Serikawa T, Sasa M. | 06/30/2012 |
| Loss of synaptic vesicle glycoprotein 2a is associated with inhibition of tetanus neurotoxin into central neurons. | SV2 mediates entry of tetanus neurotoxin into central neurons.
Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER., Free PMC Article | 03/19/2011 |
| These results indicate that SV2 performs at least two actions at the synapse that contribute to neurotransmitter release. | SV2 regulates neurotransmitter release via multiple mechanisms.
Nowack A, Yao J, Custer KL, Bajjalieh SM., Free PMC Article | 11/27/2010 |
| SV2A is selectively localized in motor nerve terminals on slow (type I and small type IIA) muscle fibers. | Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.
Chakkalakal JV, Nishimune H, Ruas JL, Spiegelman BM, Sanes JR., Free PMC Article | 10/23/2010 |
| SV2A (+/-) mice display significant increased avoidance of open elevated arms, and increased avoidance of the lit area during the first sessions of passive avoidance procedure without foot shock. | Behavioural phenotyping reveals anxiety-like features of SV2A deficient mice.
Lamberty Y, Detrait E, Leclercq K, Michel A, De Ryck M. | 01/21/2010 |
| Data demonstrate that glycosylated SV2A and SV2B act in conjunction with gangliosides to mediate the entry of BoNT/E into neurons. | Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.
Dong M, Liu H, Tepp WH, Johnson EA, Janz R, Chapman ER., Free PMC Article | 01/21/2010 |
| This study provides the first direct structural data on SV2A, and supports a transporter function suggested by sequence homology to MFS class of transporter proteins. | Visualization of SV2A conformations in situ by the use of Protein Tomography.
Lynch BA, Matagne A, Brännström A, von Euler A, Jansson M, Hauzenberger E, Söderhäll JA. | 01/21/2010 |
| findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A | SV2 is the protein receptor for botulinum neurotoxin A.
Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER. | 01/21/2010 |
| SV2 action modulates synaptic networks by ensuring that low-frequency neurotransmission is faithfully conveyed. | Synaptic vesicle protein 2 enhances release probability at quiescent synapses.
Custer KL, Austin NS, Sullivan JM, Bajjalieh SM., Free PMC Article | 01/21/2010 |