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    Sv2b synaptic vesicle glycoprotein 2 b [ Mus musculus (house mouse) ]

    Gene ID: 64176, updated on 22-Aug-2021

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AbetaPP as a Novel Interaction Partner of BACE1.

    Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE1.
    Miyamoto M, Kuzuya A, Noda Y, Ueda S, Asada-Utsugi M, Ito S, Fukusumi Y, Kawachi H, Takahashi R, Kinoshita A.

    05/15/2021
    To study the role of SV2B in maintaining the podocyte function and to better understand the function of the neuron-like vesicle expressing SV2B in the podocyte, we analyzed them with SV2B knockout (KO) mice.

    SV2B is essential for the integrity of the glomerular filtration barrier.
    Fukusumi Y, Wakamatsu A, Takashima N, Hasegawa E, Miyauchi N, Tomita M, Kawachi H.

    08/8/2015
    Glutamatergic & GABAergic transmission are unaffected by deletion of the SV2B protein. Additional deletion of SV2B does not affect the electrophysiological phenotype of SV2A deletion.

    Altered balance between excitatory and inhibitory inputs onto CA1 pyramidal neurons from SV2A-deficient but not SV2B-deficient mice.
    Venkatesan K, Alix P, Marquet A, Doupagne M, Niespodziany I, Rogister B, Seutin V.

    04/13/2013
    Loss of synaptic vesicle glycoprotein 2b is associated with inhibition of tetanus neurotoxin into central neurons.

    SV2 mediates entry of tetanus neurotoxin into central neurons.
    Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER., Free PMC Article

    03/19/2011
    These results indicate that SV2 performs at least two actions at the synapse that contribute to neurotransmitter release.

    SV2 regulates neurotransmitter release via multiple mechanisms.
    Nowack A, Yao J, Custer KL, Bajjalieh SM., Free PMC Article

    11/27/2010
    SV2 controls key aspects of synaptic functionality via its ability to regulate presynaptic Ca(2+).

    SV2 acts via presynaptic calcium to regulate neurotransmitter release.
    Wan QF, Zhou ZY, Thakur P, Vila A, Sherry DM, Janz R, Heidelberger R., Free PMC Article

    08/9/2010
    SV2B contributes to the modulation of synaptic vesicle exocytosis and plays a significant role in regulating synaptic protein content

    Loss of the Synaptic Vesicle Protein SV2B results in reduced neurotransmission and altered synaptic vesicle protein expression in the retina.
    Morgans CW, Kensel-Hammes P, Hurley JB, Burton K, Idzerda R, McKnight GS, Bajjalieh SM., Free PMC Article

    01/21/2010
    Data demonstrate that glycosylated SV2A and SV2B act in conjunction with gangliosides to mediate the entry of BoNT/E into neurons.

    Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.
    Dong M, Liu H, Tepp WH, Johnson EA, Janz R, Chapman ER., Free PMC Article

    01/21/2010
    SV2B-synaptotagmin 1 complex is involved in the regulation of synaptotagmin 1 stability and/or trafficking

    SV2B regulates synaptotagmin 1 by direct interaction.
    Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R.

    01/21/2010
    findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A

    SV2 is the protein receptor for botulinum neurotoxin A.
    Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER.

    01/21/2010
    SV2 action modulates synaptic networks by ensuring that low-frequency neurotransmission is faithfully conveyed.

    Synaptic vesicle protein 2 enhances release probability at quiescent synapses.
    Custer KL, Austin NS, Sullivan JM, Bajjalieh SM., Free PMC Article

    01/21/2010
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