| SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants as potential clinical biomarkers for personalized treatment strategy selection in patients with severe COVID-19 pneumonia. | SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants as potential clinical biomarkers for personalized treatment strategy selection in patients with severe COVID-19 pneumonia.
Fishchuk L, Rossokha Z, Pokhylko V, Cherniavska Y, Popova O, Vershyhora V, Kovtun S, Gorovenko N., Free PMC Article | 01/21/2023 |
| Silica nanoparticle exposure inhibits surfactant protein A and B in A549 cells through ROS-mediated JNK/c-Jun signaling pathway. | Silica nanoparticle exposure inhibits surfactant protein A and B in A549 cells through ROS-mediated JNK/c-Jun signaling pathway.
Yang X, Yang P, Zhang J, Yang Y, Xiong M, Shi F, Li N, Jin Y. | 08/13/2022 |
| Pulmonary surfactant protein B carried by HDL predicts incident CVD in patients with type 1 diabetes. | Pulmonary surfactant protein B carried by HDL predicts incident CVD in patients with type 1 diabetes.
Shao B, Snell-Bergeon JK, Pyle LL, Thomas KE, de Boer IH, Kothari V, Segrest J, Davidson WS, Bornfeldt KE, Heinecke JW., Free PMC Article | 05/7/2022 |
| Pulmonary surfactant-associated protein B regulates prostaglandin-endoperoxide synthase-2 and inflammation in chronic obstructive pulmonary disease. | Pulmonary surfactant-associated protein B regulates prostaglandin-endoperoxide synthase-2 and inflammation in chronic obstructive pulmonary disease.
Wang Y, Gao X, Li Y, Wang X, Li Y, Zhang S, Liu H, Guo H, Lu W, Sun D. | 04/9/2022 |
| A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C. | A dominant negative variant of RAB5B disrupts maturation of surfactant protein B and surfactant protein C.
Huang H, Pan J, Spielberg DR, Hanchard NA, Scott DA, Burrage LC, Dai H, Murdock D, Rosenfeld JA, Mohammad A, Huang T, Lindsey AG, Kim H, Chen J, Ramu A, Morrison SA, Dawson ZD, Hu AZ, Tycksen E, Silverman GA, Baldridge D, Wambach JA, Undiagnosed Diseases Network, Pak SC, Brody SL, Schedl T., Free PMC Article | 02/26/2022 |
| Regulatory Roles of Human Surfactant Protein B Variants on Genetic Susceptibility to Pseudomonas Aeruginosa Pneumonia-Induced Sepsis. | Regulatory Roles of Human Surfactant Protein B Variants on Genetic Susceptibility to Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.
Yang F, Zhang J, Yang Y, Ruan F, Chen X, Guo J, Abdel-Razek O, Zuo YY, Wang G., Free PMC Article | 10/23/2021 |
| Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer. | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer.
Moreno-Rubio J, Ponce S, Álvarez R, Olmedo ME, Falagan S, Mielgo X, Navarro F, Cruz P, Cabezón-Gutiérrez L, Aguado C, Colmenarejo G, Muñoz-Fernández de Leglaria M, Enguita AB, Cebollero M, Benito A, Alemany I, Del Castillo C, Ramos R, Ramírez de Molina A, Casado E, Sereno M., Free PMC Article | 10/9/2021 |
| Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation. | Immunohistochemical findings in the lungs of COVID-19 subjects: evidence of surfactant dysregulation.
Gerosa C, Fanni D, Cau F, Ravarino A, Senes G, Demontis R, Coni P, Piras M, Orrù G, Coghe F, Congiu T, La Nasa G, D'Aloja E, Saba L, Faa G. | 07/31/2021 |
| A primate-specific RNA-binding protein (RBMXL3) is involved in glucocorticoid regulation of human pulmonary surfactant protein B (SP-B) mRNA stability. | A primate-specific RNA-binding protein (RBMXL3) is involved in glucocorticoid regulation of human pulmonary surfactant protein B (SP-B) mRNA stability.
Liu L, Liu X, Bi W, Alcorn JL., Free PMC Article | 07/31/2021 |
| Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival. | Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival.
Pocha K, Mock A, Rapp C, Dettling S, Warta R, Geisenberger C, Jungk C, Martins LR, Grabe N, Reuss D, Debus J, von Deimling A, Abdollahi A, Unterberg A, Herold-Mende CC. | 02/6/2021 |
| Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients. | Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese Han non-small-cell lung cancer patients.
Wang K, Huang Q, Zhao G, Yang J, Yang K, Huang Y. | 08/29/2020 |
| Pulmonary surfactant protein SP-B nanorings induce the multilamellar organization of surfactant complexes. | Pulmonary surfactant protein SP-B nanorings induce the multilamellar organization of surfactant complexes.
Martinez-Calle M, Prieto M, Olmeda B, Fedorov A, Loura LMS, Pérez-Gil J. | 08/22/2020 |
| NKX2-1 mutations result in decreased expression of SFTPB and SFTPC | Mutations in the thyroid transcription factor gene NKX2-1 result in decreased expression of SFTPB and SFTPC.
Attarian SJ, Leibel SL, Yang P, Alfano DN, Hackett BP, Cole FS, Hamvas A., Free PMC Article | 10/26/2019 |
| Heterozygous previously described rare or novel variants in surfactant proteins genes ABCA3, SFTPB and SFTPC were identified in 24 newborn infants with particularly severe respiratory distress syndrome. Interaction of developmental immaturity of surfactant production in association with abnormalities of surfactant metabolism of genetic origin may have a synergic worsening phenotypic effect. | Surfactant proteins gene variants in premature newborn infants with severe respiratory distress syndrome.
Somaschini M, Presi S, Ferrari M, Vergani B, Carrera P., Free PMC Article | 09/14/2019 |
| For the first time, this study could show that infantile labial glands show expression of the surfactant proteins (SP) SP-A, SP-B, SP-C, and SP-D in acinar cells and the duct system in different intensities. | Immunolocalization of Surfactant Proteins SP-A, SP-B, SP-C, and SP-D in Infantile Labial Glands and Mucosa.
Stoeckelhuber M, Feuerhake F, Schmitz C, Wolff KD, Kesting MR., Free PMC Article | 08/3/2019 |
| Pro-SFTPB levels were significantly higher among people with HIV (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. | HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D.
Shiels MS, Kirk GD, Drummond MB, Dhillon D, Hanash SM, Taguchi A, Engels EA., Free PMC Article | 04/13/2019 |
| Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis. | Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis.
Hartjen N, Bräuer L, Reiß B, Claassen H, Beileke S, Garreis F, Hoogeboom S, Tsokos M, Etzold S, Müller-Hilke B, Gelse K, Müller T, Goldring MB, Paulsen F, Schicht M., Free PMC Article | 02/23/2019 |
| rs7316 polymorphism associated with respiratory distress syndrome in Iranian premature newborns | Association of SP-B gene 9306 A/G polymorphism (rs7316) and risk of RDS.
Fatahi N, Niknafs N, Kalani M, Dalili H, Shariat M, Amini E, Esmaeilnia Shirvani T, Hardani AK, Taheritafti R, Ghasemi-Fakhr N, Ghadami M, Tavakkoly-Bazzaz J, Rashidi-Nezhad R, Nayeri F, Rashidi-Nezhad A. | 12/22/2018 |
| TGF beta markedly decreased expression of SP-A, SP-B, SP-C, fatty acid synthase, and the phospholipid transporter ABCA3. However, TGF beta increased protein levels of SP-D with little change in mRNA levels. | TGF beta inhibits expression of SP-A, SP-B, SP-C, but not SP-D in human alveolar type II cells.
Correll KA, Edeen KE, Zemans RL, Redente EF, Mikels-Vigdal A, Mason RJ., Free PMC Article | 10/13/2018 |
| Surfactant protein B suppresses lung cancer progression by inhibiting secretory phospholipase A2 activity and arachidonic acid production. | Surfactant Protein B Suppresses Lung Cancer Progression by Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid Production.
Lee S, Kim D, Kang J, Kim E, Kim W, Youn H, Youn B. | 10/28/2017 |
| Data show that the thermal transitions observed in N-terminal propeptide of proSP-B (SP-BN) may correspond to the unfolding of certain protein domains or subdomains and/or to oligomers dissociation whereas the overall protein shows resistance to temperature-induced unfolding up to ~ 86 degrees C. | Conformational Stability of the NH2-Terminal Propeptide of the Precursor of Pulmonary Surfactant Protein SP-B.
Bañares-Hidalgo Á, Pérez-Gil J, Estrada P., Free PMC Article | 08/5/2017 |
| SP-A (+186A/G) and SP-B (1580C/T) polymorphisms are strongly associated with the risk of respiratory distress syndrome (RDS) in preterm infants. Notably, reduced serum SP-A levels were correlated with a high risk of RDS and may serve as novel biomarkers for RDS detection and monitoring. | Genetic Polymorphisms of SP-A, SP-B, and SP-D and Risk of Respiratory Distress Syndrome in Preterm Neonates.
Chang HY, Li F, Li FS, Zheng CZ, Lei YZ, Wang J., Free PMC Article | 04/29/2017 |
| Differences were found regarding SPA and pro-SPB expression in the vast majority of subjects: in some lungs, SPA was more expressed whereas in others pro-SPB showed an higher degree of immunoreactivity. The expression of both surfactant proteins was not strictly correlated with gestational age. | Interindividual variability in the expression of surfactant protein A and B in the human lung during development.
Cau F, Pisu E, Gerosa C, Senes G, Ronchi F, Botta C, Di Felice E, Uda F, Marinelli V, Faa G, Fanos V, Moretti C, Fanni D., Free PMC Article | 02/18/2017 |
| There is no significant association between the gene polymorphism of the R236C site in exon 7 of SP-B gene and the incidence ofneonatal respiratory distress syndrome (NRDS) in Han populations in that region. | [Relationship between R236C site in exon 7 of SP-B gene and respiratory distress syndrome in Han newborns in western Inner Mongolia].
Wang J, Mei H, Liu CZ, Zhang YY, Liu CL, Song D, Zhang YH., Free PMC Article | 02/4/2017 |
| Rare mutations in surfactant-associated genes contribute to neonatal respiratory distress syndrome. The frequency of mutations in these genes in the Chinese population is unknown. We resequenced all exons of the surfactant protein-B (SFTPB) and we did not find any rare mutations in SFTPB | Population-based frequency of surfactant dysfunction mutations in a native Chinese cohort.
Chen YJ, Wambach JA, DePass K, Wegner DJ, Chen SK, Zhang QY, Heins H, Cole FS, Hamvas A. | 01/14/2017 |