| Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function. | Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function.
da Silva Lima N, Fondevila MF, Nóvoa E, Buqué X, Mercado-Gómez M, Gallet S, González-Rellan MJ, Fernandez U, Loyens A, Garcia-Vence M, Chantada-Vazquez MDP, Bravo SB, Marañon P, Senra A, Escudero A, Leiva M, Guallar D, Fidalgo M, Gomes P, Claret M, Sabio G, Varela-Rey M, Delgado TC, Montero-Vallejo R, Ampuero J, López M, Diéguez C, Herrero L, Serra D, Schwaninger M, Prevot V, Gallego-Duran R, Romero-Gomez M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Garcia-Monzon C, Gonzalez-Rodriguez A, Aspichueta P, Nogueiras R. | 02/19/2022 |
| Overexpression of miR-431 attenuates hypoxia/reoxygenation-induced myocardial damage via autophagy-related 3. | Overexpression of miR-431 attenuates hypoxia/reoxygenation-induced myocardial damage via autophagy-related 3.
Zhou K, Xu Y, Wang Q, Dong L. | 06/12/2021 |
| An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy. | An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy.
Ye Y, Tyndall ER, Bui V, Tang Z, Shen Y, Jiang X, Flanagan JM, Wang HG, Tian F., Free PMC Article | 02/13/2021 |
| LncRNA NEAT1 promotes autophagy via regulating miR-204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma. | LncRNA NEAT1 promotes autophagy via regulating miR-204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma.
Li X, Zhou Y, Yang L, Ma Y, Peng X, Yang S, Li H, Liu J. | 02/6/2021 |
| Let-7c-3p Regulates Autophagy under Oxidative Stress by Targeting ATG3 in Lens Epithelial Cells. | Let-7c-3p Regulates Autophagy under Oxidative Stress by Targeting ATG3 in Lens Epithelial Cells.
Li T, Huang Y, Zhou W, Yan Q., Free PMC Article | 12/19/2020 |
| Study validated that miR-1 overexpression improved DDP sensitivity of NSCLC cells by inhibiting ATG3-mediated autophagy. | MicroRNA-1 overexpression increases chemosensitivity of non-small cell lung cancer cells by inhibiting autophagy related 3-mediated autophagy.
Hua L, Zhu G, Wei J. | 11/9/2019 |
| We have also observed membrane aggregation induced by ATG3 in vitro, which could point to a more complex function of this protein in AP biogenesis. Moreover, in vitro GABARAP lipidation assays suggest that ATG3-membrane interaction could facilitate the lipidation of ATG8 homologues. | Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge.
Hervás JH, Landajuela A, Antón Z, Shnyrova AV, Goñi FM, Alonso A., Free PMC Article | 07/6/2019 |
| Authors confirmed that the effect of PVT1 promoting autophagy was dependent on regulating ATG3 expression. Further investigations revealed that PVT1 could upregulate autophagy-related gene 3 (ATG3) expression by acting as an endogenous sponge of miR-365, which was an inhibitor gene on ATG3 protein by targeting 3'UTR of ATG3 mRNA. | Long non-coding RNA PVT1 promotes autophagy as ceRNA to target ATG3 by sponging microRNA-365 in hepatocellular carcinoma.
Yang L, Peng X, Jin H, Liu J. | 04/13/2019 |
| this study identified an amino acid motif in ATG3 causing eIF5A dependency for its efficient translation | eIF5A is required for autophagy by mediating ATG3 translation.
Lubas M, Harder LM, Kumsta C, Tiessen I, Hansen M, Andersen JS, Lund AH, Frankel LB., Free PMC Article | 04/6/2019 |
| Results revealed that miR-16 was significantly downregulated, and ATG3 was significantly upregulated in non-small cell lung carcinoma (NSCLC) patient tissue samples. ATG3 was found to be a direct target of miR-16. | miR-16 mimics inhibit TGF-β1-induced epithelial-to-mesenchymal transition via activation of autophagy in non-small cell lung carcinoma cells.
Wang H, Zhang Y, Wu Q, Wang YB, Wang W. | 07/21/2018 |
| miR-155 silencing rescued autophagosome number in Mycobacterium tuberculosis infected dendritic cells and enhanced autolysosome fusion, thereby supporting a previously unidentified role of the miR-155 as inhibitor of ATG3 expression. | Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells.
Etna MP, Sinigaglia A, Grassi A, Giacomini E, Romagnoli A, Pardini M, Severa M, Cruciani M, Rizzo F, Anastasiadou E, Di Camillo B, Barzon L, Fimia GM, Manganelli R, Coccia EM., Free PMC Article | 07/7/2018 |
| PTK2 inhibition-induced sustained levels of ATG3 were able to sensitize cancer cells to DNA-damaging agents. | PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.
Ma K, Fu W, Tang M, Zhang C, Hou T, Li R, Lu X, Wang Y, Zhou J, Li X, Zhang L, Wang L, Zhao Y, Zhu WG., Free PMC Article | 11/26/2017 |
| Our data demonstrate that HOTAIR promotes the activation of autophagy in HCC cells by upregulating the expression of the autophagy-related genes ATG3 and ATG7. | The long noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and ATG7 in hepatocellular carcinoma.
Yang L, Zhang X, Li H, Liu J. | 07/29/2017 |
| ATG3 upregulation contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells | Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells.
Yoo BH, Zagryazhskaya A, Li Y, Koomson A, Khan IA, Sasazuki T, Shirasawa S, Rosen KV., Free PMC Article | 06/28/2016 |
| Hidden Markov models were used to detect protein homology among the flexible regions of Atg3 homologs and importance of conserved regions evaluated by performing affinity capture experiments with human Atg3 deletion constructs; binding studies and competition experiments demonstrate that overlapping sites in the Atg3FR are important for E3 binding and E1 binding. | Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.
Qiu Y, Hofmann K, Coats JE, Schulman BA, Kaiser SE., Free PMC Article | 10/24/2015 |
| The region of human ATG3 that interacts with ATG7 is precisely identified using nuclear magnetic resonance. | Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes.
Ohashi K, Otomo T., Free PMC Article | 09/12/2015 |
| ATG3 gene and its gene family may play an important role in transformation of myelodysplastic syndrome. | Lentiviral vector-mediate ATG3 overexpression inhibits growth and promotes apoptosis of human SKM-1 cells.
Wang L, Song J, Zhang J, Zhu C, Ma Y, Xu X. | 12/6/2014 |
| Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. | Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.
Nath S, Dancourt J, Shteyn V, Puente G, Fong WM, Nag S, Bewersdorf J, Yamamoto A, Antonny B, Melia TJ., Free PMC Article | 08/9/2014 |
| 13 residues of the ATG3 fragment form a short beta-strand followed by an alpha-helix on a surface area that is an exclusive binding site for ATG12. | Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12.
Metlagel Z, Otomo C, Takaesu G, Otomo T., Free PMC Article | 01/25/2014 |
| caspase-8 overexpression led to Atg3 degradation and this event depended on caspase-8 enzymatic activity | Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death.
Oral O, Oz-Arslan D, Itah Z, Naghavi A, Deveci R, Karacali S, Gozuacik D. | 10/20/2012 |
| These results unveil a role for ATG12-ATG3 in mitochondrial homeostasis and implicate the ATG12 conjugation system in cellular functions distinct from the early steps of autophagosome formation. | ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.
Radoshevich L, Murrow L, Chen N, Fernandez E, Roy S, Fung C, Debnath J., Free PMC Article | 09/20/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Age at onset in Huntington's disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7.
Metzger S, Saukko M, Van Che H, Tong L, Puder Y, Riess O, Nguyen HP. | 09/15/2010 |
| Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p | Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
Tanida I, Tanida-Miyake E, Komatsu M, Ueno T, Kominami E. | 01/21/2010 |
| Murine Atg8L/Apg8L modification is mediated by human Atg3. | Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3.
Tanida I, Sou YS, Minematsu-Ikeguchi N, Ueno T, Kominami E. | 01/21/2010 |