| Contribution of Nischarin/IRAS in CNS development, injury and diseases. | Contribution of Nischarin/IRAS in CNS development, injury and diseases.
Zheng P, Pan C, Zhou C, Liu B, Wang L, Duan S, Ding Y., Free PMC Article | 12/5/2023 |
| Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function. | Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.
Yang ZH, Cai X, Ding ZL, Li W, Zhang CY, Huo JH, Zhang Y, Wang L, Zhang LM, Li SW, Li M, Zhang C, Chang H, Xiao X., Free PMC Article | 09/11/2023 |
| Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH(Delta5-6) Knockout Mouse Model. | Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH(Δ5-6) Knockout Mouse Model.
Nguyen TH, Yousefi H, Okpechi SC, Lauterboeck L, Dong S, Yang Q, Alahari SK., Free PMC Article | 03/5/2022 |
| Expression of nischarin, an imidazoline 1 receptor candidate protein, in the ventrolateral medulla of newborn rats. | Expression of nischarin, an imidazoline 1 receptor candidate protein, in the ventrolateral medulla of newborn rats.
Nagakura Y, Ide R, Saiki C, Sato Hashizume N, Imai T. | 01/15/2022 |
| These data suggest that IRAS/Nischarin may play an important role in the development of morphine tolerance and physical dependence in vivo through modulating MOR expression, as well as AMPA GluR1-S845 phosphorylation, which might be one of the mechanisms underlying the development of opiate addiction. | The role of IRAS/Nischarin involved in the development of morphine tolerance and physical dependence.
Li S, Wu N, Zhao TY, Lu GY, Wang ZY, Li F, Li J. | 04/11/2020 |
| results indicate that Nisch is an important AMPK inhibitor and a critical regulator of energy homeostasis, including lipid and glucose metabolism. | Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.
Dong S, Baranwal S, Garcia A, Serrano-Gomez SJ, Eastlack S, Iwakuma T, Mercante D, Mauvais-Jarvis F, Alahari SK., Free PMC Article | 10/21/2017 |
| We identified a significant genetic interaction between Nisch and Itga5; mice heterozygous for Itga5-null and homozygous for edison mutations display a significantly increased penetrance and severity of chronic otitis media. | A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
Crompton M, Purnell T, Tyrer HE, Parker A, Ball G, Hardisty-Hughes RE, Gale R, Williams D, Dean CH, Simon MM, Mallon AM, Wells S, Bhutta MF, Burton MJ, Tateossian H, Brown SDM., Free PMC Article | 09/16/2017 |
| Nischarin inhibits neurite outgrowth by blocking PAK1 activation in neurons. | Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity.
Ding Y, Li Y, Lu L, Zhang R, Zeng L, Wang L, Zhang X., Free PMC Article | 07/2/2016 |
| Data from studies using various receptor antagonists/agonists suggest that imidazoline receptors (Nisch I-1), alpha2-adrenoceptors, and endothelin-A receptors are involved in body temperature regulation in mice. | Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.
Bhalla S, Andurkar SV, Gulati A. | 03/15/2014 |
| Activation of I1-imidazoline receptor ameliorated energy intake and epididymal white adipose tissue accumulation. | Improvement of obesity by activation of I1-imidazoline receptors in high fat diet-fed mice.
Chung HH, Cheng J. | 03/8/2014 |
| Data suggest that both IR1 and IR2 (imidazoline receptor 2) play roles in acquisition of behavioral responses in alcoholism; activation of IR1 and IR2 may serve as molecular targets in prevention (and possibly treatment) of alcoholism. | Agmatine attenuates acquisition but not the expression of ethanol conditioned place preference in mice: a role for imidazoline receptors.
Sameer SM, Chakraborty SS, Ugale RR. | 08/31/2013 |
| Activation of cerebral I(1)-imidazoline receptor decreased hyperphagia in streptozotocin-induced diabetic mice. | Improvement of hyperphagia by activation of cerebral I(1)-imidazoline receptors in streptozotocin-induced diabetic mice.
Chung HH, Yang TT, Chen MF, Chou MT, Cheng JT. | 01/12/2013 |
| Activation of I-1 R may activate FXR to lower plasma lipids, suggesting I-1 R as a new target for the treatment of hyperlipidemia. | A novel mechanism for decreasing plasma lipid level from imidazoline I-1 receptor activation in high fat diet-fed mice.
Niu CS, Wu HT, Cheng KC, Lin KC, Chen CT, Cheng JT. | 10/1/2011 |
| Report imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. | Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Tanabe M, Hashimoto M, Ono H. | 03/11/2011 |
| guanidine increases glucose uptake via an activation of imidazoline I2 receptor through AMPK activation in skeletal muscle cell. | Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells.
Lui TN, Tsao CW, Huang SY, Chang CH, Cheng JT. | 07/12/2010 |
| Nisch regulates cell movement by inhibiting PAK. | The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK.
Alahari SK, Reddig PJ, Juliano RL., Free PMC Article | 01/21/2010 |
| Data suggest that nischarin, in addition to regulating the p21-activated kinase (PAK) strand of Rac1 signaling, can also regulate other links in the web of Rac1 signaling pathways. | Regulation of p21-activated kinase-independent Rac1 signal transduction by nischarin.
Reddig PJ, Xu D, Juliano RL. | 01/21/2010 |
| Nischarin may serve as the functional I1-receptor | Nischarin as a functional imidazoline (I1) receptor.
Zhang J, Abdel-Rahman AA. | 01/21/2010 |