| YTHDC2 Retards Cell Proliferation and Triggers Apoptosis in Papillary Thyroid Cancer by Regulating CYLD-Mediated Inactivation of Akt Signaling. | YTHDC2 Retards Cell Proliferation and Triggers Apoptosis in Papillary Thyroid Cancer by Regulating CYLD-Mediated Inactivation of Akt Signaling.
Zhou G, Wang S. | 01/26/2024 |
| Crosstalk between RNA m[6]A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells. | Crosstalk between RNA m(6)A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells.
Sun T, Xu Y, Xiang Y, Ou J, Soderblom EJ, Diao Y., Free PMC Article | 08/14/2023 |
| Overexpression of YTHDC2 contributes to the progression of prostate cancer and predicts poor outcomes in patients with prostate cancer. | Overexpression of YTHDC2 contributes to the progression of prostate cancer and predicts poor outcomes in patients with prostate cancer.
Song J, You G, Yin X, Zhu G, Wang W, Yu Y, Zhu J. | 04/14/2023 |
| lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m[6]A reader YTHDC2. | lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m(6)A reader YTHDC2.
Wang J, Tan L, Yu X, Cao X, Jia B, Chen R, Li J., Free PMC Article | 01/11/2023 |
| Construction and clinical evaluation of N6-methyladenosine risk signature of YTHDC2, IGF2BP2, and HNRNPC in head and neck squamous cell carcinoma. | Construction and clinical evaluation of N6-methyladenosine risk signature of YTHDC2, IGF2BP2, and HNRNPC in head and neck squamous cell carcinoma.
Yue Q, Xu L, Zhang D., Free PMC Article | 11/26/2022 |
| Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency. | Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency.
McGlacken-Byrne SM, Del Valle I, Quesne Stabej PL, Bellutti L, Garcia-Alonso L, Ocaka LA, Ishida M, Suntharalingham JP, Gagunashvili A, Ogunbiyi OK, Mistry T, Buonocore F, GOSgene, Crespo B, Moreno N, Niola P, Brooks T, Brain CE, Dattani MT, Kelberman D, Vento-Tormo R, Lagos CF, Livera G, Conway GS, Achermann JC., Free PMC Article | 04/30/2022 |
| The m(6)A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay. | The m(6)A reader YTHDC2 is essential for escape from KSHV SOX-induced RNA decay.
Macveigh-Fierro D, Cicerchia A, Cadorette A, Sharma V, Muller M., Free PMC Article | 03/19/2022 |
| Downregulation of m(6)A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-kappaB Pathway. | Downregulation of m(6)A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway.
Wang J, Tan L, Jia B, Yu X, Yao R, OUYang N, Yu X, Cao X, Tong J, Chen T, Chen R, Li J., Free PMC Article | 03/19/2022 |
| N6-methyladenosine reader YTHDC2 and eraser FTO may determine hepatocellular carcinoma prognoses after transarterial chemoembolization. | N6-methyladenosine reader YTHDC2 and eraser FTO may determine hepatocellular carcinoma prognoses after transarterial chemoembolization.
Liu J, Wang D, Zhou J, Wang L, Zhang N, Zhou L, Zeng J, Liu J, Yang M. | 11/22/2021 |
| Targeting SLC3A2 subunit of system XC(-) is essential for m(6)A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma. | Targeting SLC3A2 subunit of system X(C)(-) is essential for m(6)A reader YTHDC2 to be an endogenous ferroptosis inducer in lung adenocarcinoma.
Ma L, Zhang X, Yu K, Xu X, Chen T, Shi Y, Wang Y, Qiu S, Guo S, Cui J, Miao Y, Tian X, Du L, Yu Y, Xia J, Wang J. | 08/21/2021 |
| N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition. | N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition.
Kim GW, Siddiqui A., Free PMC Article | 08/21/2021 |
| N(6) -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes. | N(6) -Methyladenosine Reader Protein YT521-B Homology Domain-Containing 2 Suppresses Liver Steatosis by Regulation of mRNA Stability of Lipogenic Genes.
Zhou B, Liu C, Xu L, Yuan Y, Zhao J, Zhao W, Chen Y, Qiu J, Meng M, Zheng Y, Wang D, Gao X, Li X, Zhao Q, Wei X, Wu D, Zhang H, Hu C, Zhuo X, Zheng M, Wang H, Lu Y, Ma X. | 06/19/2021 |
| [Role of m (6)A Reader YTHDC2 in Differentiation of Human Bone Marrow Mesenchymal Stem Cells]. | [Role of m (6)A Reader YTHDC2 in Differentiation of Human Bone Marrow Mesenchymal Stem Cells].
Wen JR, Tan Z, Lin WM, Li QW, Yuan Q., Free PMC Article | 06/12/2021 |
| [LIM-domain binding protein 2 regulated by m(6)A modification inhibits lung adenocarcinoma cell proliferation in vitro]. | [LIM-domain binding protein 2 regulated by m(6)A modification inhibits lung adenocarcinoma cell proliferation in vitro].
Zhai D, Wang G, Li L, Jia X, Zheng G, Yin J., Free PMC Article | 04/17/2021 |
| m(6) A RNA methylation regulators contribute to malignant progression in rectal cancer. | m(6) A RNA methylation regulators contribute to malignant progression in rectal cancer.
Zhuang J, Lin C, Ye J. | 03/13/2021 |
| Genetic variants in m6A modification genes are associated with esophageal squamous-cell carcinoma in the Chinese population. | Genetic variants in m6A modification genes are associated with esophageal squamous-cell carcinoma in the Chinese population.
Yang N, Ying P, Tian J, Wang X, Mei S, Zou D, Peng X, Gong Y, Yang Y, Zhu Y, Ke J, Zhong R, Chang J, Miao X. | 10/31/2020 |
| The (6)-methyladenosine (m(6)A) binding pocket is conserved in YTH domain of ATP-dependent RNA helicase YTHDC2 (YTHDC2). | Crystal structure of human YTHDC2 YTH domain.
Ma C, Liao S, Zhu Z. | 06/6/2020 |
| YTHDC2 was recently found to promote a "fast-track" expression program for specific mRNAs, and our data suggest that YTHDC2 accomplishes this by recruitment of the RNA degradation machinery to regulate the stability of m(6)A-containing mRNAs and by utilizing its distinct RNA-binding domains to bridge interactions between m(6)A-containing mRNAs and the ribosomes to facilitate their efficient translation. | The m(6)A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5'-3' exoribonuclease XRN1.
Kretschmer J, Rao H, Hackert P, Sloan KE, Höbartner C, Bohnsack MT., Free PMC Article | 09/29/2018 |
| Suggest that RNA helicase YTHDC2 contributes to colon adenocarcinoma metastasis by promoting translation of HIF-1alpha. | RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.
Tanabe A, Tanikawa K, Tsunetomi M, Takai K, Ikeda H, Konno J, Torigoe T, Maeda H, Kutomi G, Okita K, Mori M, Sahara H. | 02/18/2017 |
| binding affinities of the YTH domains of three human proteins and yeast YTH domain protein Pho92 | Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.
Xu C, Liu K, Ahmed H, Loppnau P, Schapira M, Min J., Free PMC Article | 01/16/2016 |
| Our results suggest that the YTHDC2 gene could be a potential candidate for pancreatic cancer susceptibility and a useful marker for early detection | Germline copy number variation in the YTHDC2 gene: does it have a role in finding a novel potential molecular target involved in pancreatic adenocarcinoma susceptibility?
Fanale D, Iovanna JL, Calvo EL, Berthezene P, Belleau P, Dagorn JC, Bronte G, Cicero G, Bazan V, Rolfo C, Santini D, Russo A. | 03/7/2015 |
| data show that YTHDC2 plays an important role in tumor cells growth and activation/recruitment of c-Jun and ATF-2 to the YTHDC2 promoter is necessary for the transcription of YTHDC2 | Transcriptional machinery of TNF-α-inducible YTH domain containing 2 (YTHDC2) gene.
Tanabe A, Konno J, Tanikawa K, Sahara H. | 03/1/2014 |
| CAHL is a CsA associated helicase-like protein, which would form trimer complex with cyclophilin B and NS5B of HCV. | Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B.
Morohashi K, Sahara H, Watashi K, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F., Free PMC Article | 09/14/2012 |