| Sodium-calcium exchanger-3 regulates pain ""wind-up"": From human psychophysics to spinal mechanisms. | Sodium-calcium exchanger-3 regulates pain "wind-up": From human psychophysics to spinal mechanisms.
Trendafilova T, Adhikari K, Schmid AB, Patel R, Polgár E, Chisholm KI, Middleton SJ, Boyle K, Dickie AC, Semizoglou E, Perez-Sanchez J, Bell AM, Ramirez-Aristeguieta LM, Khoury S, Ivanov A, Wildner H, Ferris E, Chacón-Duque JC, Sokolow S, Saad Boghdady MA, Herchuelz A, Faux P, Poletti G, Gallo C, Rothhammer F, Bedoya G, Zeilhofer HU, Diatchenko L, McMahon SB, Todd AJ, Dickenson AH, Ruiz-Linares A, Bennett DL., Free PMC Article | 08/27/2022 |
| The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer. | The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.
Xia Z, Wang C, Zhang H., Free PMC Article | 06/19/2021 |
| These results...suggest that cells can use a dynamic Ca(2+) signaling toolkit in which the NCX3 sub-cellular localization changes in synchrony with the cell cycle | Glycosylation controls sodium-calcium exchanger 3 sub-cellular localization during cell cycle.
Liu T, Zhao J, Ibarra C, Garcia MU, Uhlén P, Nistér M. | 09/1/2018 |
| Structure-Dynamic Coupling Through Ca(2+)-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants | Structure-Dynamic Coupling Through Ca(2+)-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.
Khananshvili D. | 08/18/2018 |
| stimulation of NCX3 by PKA occurred through residue S524. This effect may well participate in the fight-or-flight response in skeletal muscle and the long-term potentiation in hippocampus. | Differential regulation of the Na(+)-Ca(2+) exchanger 3 (NCX3) by protein kinase PKC and PKA.
Michel LYM, Verkaart S, Latta F, Hoenderop JGJ, Bindels RJM. | 03/10/2018 |
| In the discovery phase, 60 loci not previously associated with rheumatoid arthritis risk showed evidence for association and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level. When combining the discovery and validation cohorts, an intronic SNP in SLC8A3 was found to be associated with ACPA-positive rheumatoid arthritis at a genome-wide level of significance. | A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis.
Julià A, González I, Fernández-Nebro A, Blanco F, Rodriguez L, González A, Cañete JD, Maymó J, Alperi-López M, Olivé A, Corominas H, Martínez-Taboada V, Erra A, Sánchez-Fernández S, Alonso A, Lopez-Lasanta M, Tortosa R, Codó L, Gelpi JL, García-Montero AC, Bertranpetit J, Absher D, Bridges SL Jr, Myers RM, Tornero J, Marsal S. | 06/24/2017 |
| Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain. | Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.
Atherton J, Kurbatskaya K, Bondulich M, Croft CL, Garwood CJ, Chhabra R, Wray S, Jeromin A, Hanger DP, Noble W., Free PMC Article | 11/22/2014 |
| human macrophages and monocytes express NCX1 and NCX3 that operate in a bidirectional manner to restore [Ca(2+)](i) to generate Ca(2+) signals and to induce TNF-alpha production. | Human macrophages and monocytes express functional Na(+)/Ca (2+) exchangers 1 and 3.
Staiano RI, Granata F, Secondo A, Petraroli A, Loffredo S, Annunziato L, Triggiani M, Marone G. | 03/16/2013 |
| Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 and NCX3, but not NCX2, were divergently modulated during OPC differentiation into oligodendrocyte. | New roles of NCX in glial cells: activation of microglia in ischemia and differentiation of oligodendrocytes.
Boscia F, D'Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, Guida N, Scorziello A, Di Renzo G, Annunziato L. | 03/16/2013 |
| the large cytosolic loop of NCX1, NCX2, and NCX3 is involved in acquisition of immunosuppressive drug specificity | Immunosuppressive drugs, immunophilins, and functional expression of NCX isoforms.
Rahamimoff H, Elbaz B, Valitsky M, Khatib M, Eskin-Schwartz M, Elmaz D. | 03/16/2013 |
| NCX isoforms (NCX2, NCX3) contribute to mitochondrial Na(+)/Ca(2+) exchange in human DAergic neurons and may act downstream of PINK1 in the prevention of neurodegeneration by m[Ca(2+)] accumulation. | The role of the mitochondrial NCX in the mechanism of neurodegeneration in Parkinson's disease.
Wood-Kaczmar A, Deas E, Wood NW, Abramov AY. | 03/16/2013 |
| NCX1 and NCX3 -represent two promising druggable targets for setting on new strategies in stroke therapy. | NCX as a key player in the neuroprotection exerted by ischemic preconditioning and postconditioning.
Pignataro G, Cuomo O, Vinciguerra A, Sirabella R, Esposito E, Boscia F, Di Renzo G, Annunziato L. | 03/16/2013 |
| calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation. | Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation.
Boscia F, D'Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, Guida N, Sokolow S, Herchuelz A, Annunziato L., Free PMC Article | 07/7/2012 |
| Human platelets express K(+) -independent Na(+) /Ca(2+) exchangers NCX1.3, NCX3.2 and NCX3.4. | Molecular and functional characterization of the human platelet Na(+) /Ca(2+) exchangers.
Roberts DE, Matsuda T, Bose R., Free PMC Article | 05/19/2012 |
| Data suggest that NCX-mediated Ca(2+) fluxes normally exist in human ASM (potentially contributing to rapid Ca(2+) fluxes), and contribute to enhanced [Ca(2+)](i) regulation in airway inflammation. | Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.
Sathish V, Delmotte PF, Thompson MA, Pabelick CM, Sieck GC, Prakash YS., Free PMC Article | 02/18/2012 |
| Results demonstrate a selective regulation of NCX1, NCX2 and NCX3 isoforms in Alzheimer's disease cortex, specifically in terminals containing amyloid-beta. | High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.
Sokolow S, Luu SH, Headley AJ, Hanson AY, Kim T, Miller CA, Vinters HV, Gylys KH., Free PMC Article | 08/27/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| plasma membrane Na+/Ca2+ exchangers have inhibitory interactions with the 14-3-3 proteins | Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.
Pulina MV, Rizzuto R, Brini M, Carafoli E. | 01/21/2010 |
| The downregulation of the regulator of Ca2+ homeostasis NCX3 by Ca2+-regulated DREAM is a striking example of the autoregulatory property of the Ca2+ signal in neurons. | Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.
Gomez-Villafuertes R, Torres B, Barrio J, Savignac M, Gabellini N, Rizzato F, Pintado B, Gutierrez-Adan A, Mellström B, Carafoli E, Naranjo JR., Free PMC Article | 01/21/2010 |
| Studies show that both alternatively spliced variants can be translated into protein. | Molecular cloning and characterization of two novel truncated isoforms of human Na+/Ca2+ exchanger 3, expressed in fetal brain.
Lindgren RM, Zhao J, Heller S, Berglind H, Nistér M. | 01/21/2010 |
| The gene promoter of the human isoform of this protein is controlled by cAMP and calcium. | The gene promoter of human Na+/Ca2+ exchanger isoform 3 (SLC8A3) is controlled by cAMP and calcium.
Gabellini N, Bortoluzzi S, Danieli GA, Carafoli E. | 01/21/2010 |
| This review examines the regulatory features and expression pattern of the SLC8A3 gene which suggest that NCX3 activity could be crucial in neuronal functions such as memory formation and sensory processing. | Transcriptional regulation by cAMP and Ca2+ links the Na+/Ca2+ exchanger 3 to memory and sensory pathways.
Gabellini N. | 01/21/2010 |