| zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma. | zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma.
Zhang X, Hou J, Zhou G, Wang H, Wu Z., Free PMC Article | 04/18/2024 |
| Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells. | Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells.
Zhou K, Amiri M, Salari A, Yu Y, Xu H, Seidler U, Nikolovska K. | 09/25/2021 |
| Differentiated Caco-2BBe cells display particularly high mRNA expression levels of NHE2, which can be functionally identified in the apical membrane. Although at low intracellular pH, NHE2 transport rate was far lower than that of NHE1. NHE2 activity was nevertheless essential for the maintenance of the steady-state pHi of these cells. | Expression, Localization and Functional Activity of the Major Na⁺/H⁺ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe.
Yu Y, Seidler A, Zhou K, Yuan Z, Yeruva S, Amiri M, Yun CC, Nikolovska K, Seidler U., Free PMC Article | 05/4/2019 |
| Studies show that phosphorylation of the NHE3 at a single amino acid in the distal part of the C-terminus affects multiple aspects of NHE3 complex formation and changes the NHE3 lipid raft distribution, which cause changes in specific aspects of basal as well as acutely stimulated and inhibited Na(+)/H(+) exchange activity. | Phosphorylation of NHE3-S(719) regulates NHE3 activity through the formation of multiple signaling complexes.
Sarker R, Cha B, Kovbasnjuk O, Cole R, Gabelli S, Tse CM, Donowitz M., Free PMC Article | 11/18/2017 |
| These data indicate that the acid-dependent NHE2 stimulation is implemented by transcriptional upregulation of NHE2 via acid-induced Egr-1 in the intestinal epithelial cells. | Extracellular acidosis stimulates NHE2 expression through activation of transcription factor Egr-1 in the intestinal epithelial cells.
Muthusamy S, Cheng M, Jeong JJ, Kumar A, Dudeja PK, Malakooti J., Free PMC Article | 03/7/2015 |
| Phosphorylation of nPKC-delta results in activation of ERK1/2 kinase and subsequent induction of Egr-1. Subsequently, Egr-1 directly targets NHE2 promoter and promotes NHE2 transcriptional upregulation by interaction with NHE2-PMA response element. | PKCδ-dependent activation of ERK1/2 leads to upregulation of the human NHE2 transcriptional activity in intestinal epithelial cell line C2BBe1.
Muthusamy S, Shukla S, Amin MR, Cheng M, Orenuga T, Dudeja PK, Malakooti J., Free PMC Article | 04/28/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The functional and molecular expression of NHEs in cultured human endolymphatic sac (ES) epithelial cells was determined and the effect of IFN-gamma on NHE function, was examined. | Interferon-gamma suppresses Na+ -H+ exchanger in cultured human endolymphatic sac epithelial cells.
Son EJ, Moon IS, Kim SH, Kim SJ, Choi JY. | 01/21/2010 |
| Report morphological adaptation with preserved proliferation/NHE2 content in the colon of patients with short bowel syndrome. | Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome.
Joly F, Mayeur C, Messing B, Lavergne-Slove A, Cazals-Hatem D, Noordine ML, Cherbuy C, Duée PH, Thomas M. | 01/21/2010 |
| Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cells. | Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.
Musch MW, Arvans DL, Wu GD, Chang EB., Free PMC Article | 01/21/2010 |
| T84 human colon cells contain three isoforms of the Na+/H+ exchanger, NHE1, NHE2, and NHE4, but not the Cl-dependent NHE | NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells.
Beltrán AR, Ramírez MA, Carraro-Lacroix LR, Hiraki Y, Rebouças NA, Malnic G. | 01/21/2010 |
| No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA. | Familial pure proximal renal tubular acidosis--a clinical and genetic study.
Katzir Z, Dinour D, Reznik-Wolf H, Nissenkorn A, Holtzman E. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Extensive genetic analysis of 10 candidate genes for hypertension in Japanese.
Iwai N, Kajimoto K, Kokubo Y, Tomoike H. | 03/13/2008 |
| expression of the human NHE2 promoter is controlled by Sp1 and Sp3 by interactions with the proximal promoter and the transcription initiation site of NHE2 | Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site.
Pearse I, Zhu YX, Murray EJ, Dudeja PK, Ramaswamy K, Malakooti J., Free PMC Article | 01/21/2010 |
| In humans, NHE2 transcripts appear to be gestationally regulated, which may contribute to changes in NHE activity. | Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR.
Lacey HA, Nolan T, Greenwood SL, Glazier JD, Sibley CP. | 01/21/2010 |