| Pit 1 transporter (SLC20A1) as a key factor in the NPP1-mediated inhibition of insulin signaling in human podocytes. | Pit 1 transporter (SLC20A1) as a key factor in the NPP1-mediated inhibition of insulin signaling in human podocytes.
Kulesza T, Typiak M, Rachubik P, Rogacka D, Audzeyenka I, Saleem MA, Piwkowska A. | 08/19/2023 |
| Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT. | Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT.
Zechner C, Henne WM, Sathe AA, Xing C, Hernandez G, Sun S, Cheong MC., Free PMC Article | 07/2/2022 |
| Long Noncoding RNA SLC20A1-1 Induces Nucleus Pulposus Apoptosis by Sponging miR-146a-5p. | Long Noncoding RNA SLC20A1-1 Induces Nucleus Pulposus Apoptosis by Sponging miR-146a-5p.
Chen Y, Hua Q, Wan H, Xi Y. | 04/9/2022 |
| Genome-wide methylation association with current suicidal ideation in schizophrenia. | Genome-wide methylation association with current suicidal ideation in schizophrenia.
Bani-Fatemi A, Adanty C, Dai N, Dada O, Strauss J, Zai C, Gerretsen P, Graff A, De Luca V. | 10/23/2021 |
| The present data suggested that SLC20A1 levels are positively associated with tumor size, invasive behavior and tumor recurrence in somatotroph adenomas. Furthermore, SLC20A1 may be associated with the activation of the Wnt/betacatenin signaling pathway. | Impact of SLC20A1 on the Wnt/β‑catenin signaling pathway in somatotroph adenomas.
Li J, Dong W, Li Z, Wang H, Gao H, Zhang Y., Free PMC Article | 02/8/2020 |
| Targeted sequencing of two candidate genes, SLC20A1 and SLC15A4, of the solute carrier membrane transport protein family in 200 additional patients demonstrated two further variants predicted as damaging for combined hormone deficiency. | Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency.
Simm F, Griesbeck A, Choukair D, Weiß B, Paramasivam N, Klammt J, Schlesner M, Wiemann S, Martinez C, Hoffmann GF, Pfäffle RW, Bettendorf M, Rappold GA. | 12/22/2018 |
| Overexpression of SLC20A1 is associated with Estrogen Receptor-positive Breast Cancer. | Expression Levels of KMT2C and SLC20A1 Identified by Information-theoretical Analysis Are Powerful Prognostic Biomarkers in Estrogen Receptor-positive Breast Cancer.
Sato K, Akimoto K. | 03/17/2018 |
| indoxyl sulfate promotes Pit-1 expression in part by activation of the JNK pathway in vascular smooth muscle cells | Indoxyl sulfate promotes vascular smooth muscle cell calcification via the JNK/Pit-1 pathway.
Wu Y, Han X, Wang L, Diao Z, Liu W. | 05/20/2017 |
| Ox-LDL induces an osteogenic change in human aortic valve interstitial cells marked by the induction of PiT-1. | ox-LDL induces PiT-1 expression in human aortic valve interstitial cells.
Nadlonek NA, Lee JH, Weyant MJ, Meng X, Fullerton DA., Free PMC Article | 11/16/2013 |
| Overexpression of SLC20A1 promotes apoptosis and mineralization by altering the level of Akt-1. | High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1.
El Husseini D, Boulanger MC, Fournier D, Mahmut A, Bossé Y, Pibarot P, Mathieu P., Free PMC Article | 07/6/2013 |
| Allelic variations in SLC20A1 were associated with the levels of Sodium-lithium countertransport. | Association between SLC20A1 and sodium-lithium countertransport.
Zheng X, Morrison AC, Turner ST, Ferrell RE. | 01/14/2012 |
| the human PiT2 histidine, H(502), and the human PiT1 glutamate, E(70),--both conserved in eukaryotic PiT family members--are critical for P(i) transport function | Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life.
Bøttger P, Pedersen L., Free PMC Article | 10/8/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadié M, Foretová L, Cocco P, González-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S., Free PMC Article | 12/5/2010 |
| Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis. | Identification of a novel transport-independent function of PiT1/SLC20A1 in the regulation of TNF-induced apoptosis.
Salaün C, Leroy C, Rousseau A, Boitez V, Beck L, Friedlander G., Free PMC Article | 12/4/2010 |
| PiT1 depletion markedly reduces cell proliferation, delays cell cycle, and impairs mitosis and cytokinesis. | Identification of a novel function of PiT1 critical for cell proliferation and independent of its phosphate transport activity.
Beck L, Leroy C, Salaün C, Margall-Ducos G, Desdouets C, Friedlander G., Free PMC Article | 01/21/2010 |
| An overexpression of Pit-1 seems to play a key role in the formation of soft tissue calcification in Werner syndrome. | Clinical outcome and mechanism of soft tissue calcification in Werner syndrome.
Honjo S, Yokote K, Fujimoto M, Takemoto M, Kobayashi K, Maezawa Y, Shimoyama T, Satoh S, Koshizaka M, Takada A, Irisuna H, Saito Y. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.
Walker LC, Waddell N, Ten Haaf A, kConFab Investigators, Grimmond S, Spurdle AB. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks.
Meyers KJ, Mosley TH, Fox E, Boerwinkle E, Arnett DK, Devereux RB, Kardia SL. | 03/13/2008 |
| Analysis of kinetics and substrate specificity of SLC20A1. | Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements.
Ravera S, Virkki LV, Murer H, Forster IC. | 01/21/2010 |
| Phosphate uptake through Pit-1 is essential for vascular smooth muscle cell calcification and phenotypic modulation in response to elevated phosphate. | Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification.
Li X, Yang HY, Giachelli CM. | 01/21/2010 |
| Two highly conserved glutamate residues critical for sodium-dependent phosphate transport are revealed by uncoupling transport function from retroviral receptor function. | Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function.
Bottger P, Pedersen L. | 01/21/2010 |
| propose that region A of Pit1 confers competence for viral entry by influencing the topology of the authentic binding site in the membrane and hence its accessibility to a viral envelope protein | Reassessing the role of region A in Pit1-mediated viral entry.
Farrell KB, Russ JL, Murthy RK, Eiden MV., Free PMC Article | 01/21/2010 |
| Our results link low-grade IL-8-mediated cartilaginous inflammation in OA to altered chondrocyte differentiation and disease progression through PiT-1 expression and sodium-dependent Pi uptake mediated by CXCR1 signaling. | Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.
Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R. | 01/21/2010 |
| Results describe the characterization of transport mechanisms and determinants critical for sodium-dependent phosphate symport of the PiT family paralogs human PiT1 and PiT2. | Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.
Bøttger P, Hede SE, Grunnet M, Høyer B, Klaerke DA, Pedersen L. | 01/21/2010 |