| Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy. | Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy.
Liu X, Li B, Wang S, Zhang E, Schultz M, Touma M, Monteiro Da Rocha A, Evans SM, Eichmann A, Herron T, Chen R, Xiong D, Jaworski A, Weiss S, Si MS., Free PMC Article | 04/3/2024 |
| Abnormal expression of SLIT3 induces intravillous vascularization dysplasia in ectopic pregnancy. | Abnormal expression of SLIT3 induces intravillous vascularization dysplasia in ectopic pregnancy.
Zhu Q, Zhao X, Zhang D, Xia W, Zhang J., Free PMC Article | 02/17/2023 |
| LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis. | LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis.
Duan X, Wang L, Wang Z, Wei W, Wang M, Ding D. | 09/3/2022 |
| LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis. | LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis.
Tang Y, Cai J, Lv B., Free PMC Article | 02/26/2022 |
| Single-nucleotide polymorphism rs10036727 in the SLIT3 gene is associated with osteoporosis at the femoral neck in older Mexican postmenopausal women. | Single-nucleotide polymorphism rs10036727 in the SLIT3 gene is associated with osteoporosis at the femoral neck in older Mexican postmenopausal women.
Hidalgo-Bravo A, Hernández-Medrano C, Sevilla-Montoya R, Rivera-Paredez B, Ramirez-Salazar EG, Flores-Morales J, Patiño N, Salmeron J, Valdés-Flores M, Velázquez-Cruz R. | 10/2/2021 |
| Isolated congenital diaphragm hernia associated with homozygous SLIT3 gene variant in dizygous twins. | Isolated congenital diaphragm hernia associated with homozygous SLIT3 gene variant in dizygous twins.
Kaya TB, Aydemir O, Ceylaner S, Ceylaner G, Tekin AN. | 08/14/2021 |
| Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. | Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour.
García-González J, Brock AJ, Parker MO, Riley RJ, Joliffe D, Sudwarts A, Teh MT, Busch-Nentwich EM, Stemple DL, Martineau AR, Kaprio J, Palviainen T, Kuan V, Walton RT, Brennan CH., Free PMC Article | 04/3/2021 |
| the level of gingival crevicular fluid SLIT3 was higher in patients with periodontitis than in healthy individuals and was closely associated with clinical attachment loss and radiographic bone loss | Gingival crevicular fluid levels of SLIT3 are increased in periodontal disease.
Zhong W, Peng Y, Yue E, Huang B, Zhang W, Zhao Z, Jiang J, Wang Q, Zhao H. | 01/25/2020 |
| SLIT3 and SPARCL1 can be regulated by DNA methylation and down-regulated in lung adenocarcinoma | [Expression and prognosis effect of methylation-regulated SLIT3 and SPARCL1 genes in smoking-related lung adenocarcinoma].
Wang J, Yu XF, Ouyang N, Zhao SY, Guan XF, Yao HP, Chen R, Chen T, Li JX. | 06/15/2019 |
| High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increase susceptibility to increased insulin resistance by 50% and its risk may be exacerbated by consuming more than 10 cups coffee/week or 220 mg caffeine/day. | High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increased insulin resistance and interacted with coffee and caffeine consumption in middle-aged adults.
Daily JW, Liu M, Park S. | 03/16/2019 |
| This study suggests that Slit3 acts as a tumor suppressor in hepatocellular carcinoma by repressing the tumor growth and thus tumor progression | Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway.
Ng L, Chow AKM, Man JHW, Yau TCC, Wan TMH, Iyer DN, Kwan VHT, Poon RTP, Pang RWC, Law WL., Free PMC Article | 02/16/2019 |
| Overexpression of Slit3 induces its tumor suppressive effects in Breast cancer. | Function of Slit/Robo signaling in breast cancer.
Gu F, Ma Y, Zhang J, Qin F, Fu L. | 09/24/2016 |
| Results show that silencing of Slit3 promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 functions as a tumor suppressor in lung carcinoma. | Effects of Slit3 silencing on the invasive ability of lung carcinoma A549 cells.
Zhang C, Guo H, Li B, Sui C, Zhang Y, Xia X, Qin Y, Ye L, Xie F, Wang H, Yuan M, Yuan L, Ye J. | 04/30/2016 |
| Estrogen-dependent expression of SLIT3 may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions. | Estrogen receptor (ER) agonists differentially regulate neuroangiogenesis in peritoneal endometriosis via the repellent factor SLIT3.
Greaves E, Collins F, Esnal-Zufiaurre A, Giakoumelou S, Horne AW, Saunders PT. | 01/10/2015 |
| SLIT3 is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 in these tissues. | SLIT3 is increased in supracervical human foetal membranes and in labouring myometrium and regulates pro-inflammatory mediators.
Lim R, Barker G, Lappas M. | 11/22/2014 |
| High SLIT3 expression is associated with high-grade gliomas. | Experimental validation of 5 in-silico predicted glioma biomarkers.
Towner RA, Jensen RL, Vaillant B, Colman H, Saunders D, Giles CB, Wren JD., Free PMC Article | 07/12/2014 |
| SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. | SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo.
Paul JD, Coulombe KLK, Toth PT, Zhang Y, Marsboom G, Bindokas VP, Smith DW, Murry CE, Rehman J., Free PMC Article | 06/14/2014 |
| results implicate the involvement of miR-218-2 and its host gene SLIT3 in thyroid cancer cell invasion, migration, and proliferation | Down-regulation of miR-218-2 and its host gene SLIT3 cooperate to promote invasion and progression of thyroid cancer.
Guan H, Wei G, Wu J, Fang D, Liao Z, Xiao H, Li M, Li Y. | 11/16/2013 |
| Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo. | Control of human hematopoietic stem/progenitor cell migration by the extracellular matrix protein Slit3.
Geutskens SB, Andrews WD, van Stalborch AM, Brussen K, Holtrop-de Haan SE, Parnavelas JG, Hordijk PL, van Hennik PB. | 11/17/2012 |
| three major members (Slit2/3 and Robo1) of Slit/Robo family are widely expressed in the human normal and malignant ovarian tissues; but Slit/Robo signaling may not play an important role in regulating human ovarian cancer cell proliferation and migration | Expression and roles of Slit/Robo in human ovarian cancer.
Dai CF, Jiang YZ, Li Y, Wang K, Liu PS, Patankar MS, Zheng J., Free PMC Article | 02/11/2012 |
| SLIT3 duplication on 5q35.1 predisposes to major depressive disorder | Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder.
Glessner JT, Wang K, Sleiman PM, Zhang H, Kim CE, Flory JH, Bradfield JP, Imielinski M, Frackelton EC, Qiu H, Mentch F, Grant SF, Hakonarson H., Free PMC Article | 07/9/2011 |
| The chemorepellent Slit3 promotes monocyte migration. | The chemorepellent Slit3 promotes monocyte migration.
Geutskens SB, Hordijk PL, van Hennik PB. | 01/8/2011 |
| Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. | Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis.
Denk AE, Kaufmann S, Stark K, Schedel J, Lowin T, Schubert T, Bosserhoff AK., Free PMC Article | 09/27/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| functions to promote angiogenesis in coordinating organogenesis during embryonic development | Repulsive axon guidance molecule Slit3 is a novel angiogenic factor.
Zhang B, Dietrich UM, Geng JG, Bicknell R, Esko JD, Wang L., Free PMC Article | 01/21/2010 |