| Targeting ZIP8 mediated ferroptosis as a novel strategy to protect against the retinal pigment epithelial degeneration. | Targeting ZIP8 mediated ferroptosis as a novel strategy to protect against the retinal pigment epithelial degeneration.
Liu Z, Huang J, Li D, Zhang C, Wan H, Zeng B, Tan Y, Zhong F, Liao H, Liu M, Chen ZS, Zou C, Liu D, Qin B. | 03/6/2024 |
| Metal-ion transporter SLC39A8 is required for brain manganese uptake and accumulation. | Metal-ion transporter SLC39A8 is required for brain manganese uptake and accumulation.
Liu Q, Jenkitkasemwong S, Prami TA, McCabe SM, Zhao N, Hojyo S, Fukada T, Knutson MD., Free PMC Article | 09/1/2023 |
| Loss of hepatic manganese transporter ZIP8 disrupts serum transferrin glycosylation and the glutamate-glutamine cycle. | Loss of hepatic manganese transporter ZIP8 disrupts serum transferrin glycosylation and the glutamate-glutamine cycle.
Powers M, Minchella D, Gonzalez-Acevedo M, Escutia-Plaza D, Wu J, Heger C, Milne G, Aschner M, Liu Z. | 06/2/2023 |
| A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection. | A mouse model characterizes the roles of ZIP8 in systemic iron recycling and lung inflammation and infection.
Zhang V, Jenkitkasemwong S, Liu Q, Ganz T, Nemeth E, Knutson MD, Kim A., Free PMC Article | 04/5/2023 |
| The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density. | The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density.
Li S, Ma C, Li Y, Chen R, Liu Y, Wan LP, Xiong Q, Wang C, Huo Y, Dang X, Yang Y, Lv L, Chen X, Sheng N, Li W, Luo XJ., Free PMC Article | 09/24/2022 |
| Protective effects of ZIP8 on Toxoplasma gondii-induced acute hepatocyte injury in mice. | Protective effects of ZIP8 on Toxoplasma gondii-induced acute hepatocyte injury in mice.
Wang Y, Wang C, Chen H, Zhang Y, Gao N, Yu Y, Xing Y, Xie L, Wang Z, Cai Y. | 08/27/2022 |
| The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain. | The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain.
Mealer RG, Williams SE, Noel M, Yang B, D'Souza AK, Nakata T, Graham DB, Creasey EA, Cetinbas M, Sadreyev RI, Scolnick EM, Woo CM, Smoller JW, Xavier RJ, Cummings RD., Free PMC Article | 05/21/2022 |
| ZIP8 exacerbates collagen-induced arthritis by increasing pathogenic T cell responses. | ZIP8 exacerbates collagen-induced arthritis by increasing pathogenic T cell responses.
Kang JA, Kwak JS, Park SH, Sim KY, Kim SK, Shin Y, Jung IJ, Yang JI, Chun JS, Park SG., Free PMC Article | 04/2/2022 |
| ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia. | ZIP8-Mediated Intestinal Dysbiosis Impairs Pulmonary Host Defense against Bacterial Pneumonia.
Samuelson DR, Smith DR, Cunningham KC, Wyatt TA, Hall SC, Murry DJ, Chhonker YS, Knoell DL., Free PMC Article | 03/12/2022 |
| Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia. | Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia.
Hall SC, Smith DR, Dyavar SR, Wyatt TA, Samuelson DR, Bailey KL, Knoell DL., Free PMC Article | 09/11/2021 |
| Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease. | Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease.
Sunuwar L, Frkatović A, Sharapov S, Wang Q, Neu HM, Wu X, Haritunians T, Wan F, Michel S, Wu S, Donowitz M, McGovern D, Lauc G, Sears C, Melia J., Free PMC Article | 05/22/2021 |
| The knockdown of Zip8 impaired activity of the Mn-dependent SOD2. | Manganese influx and expression of ZIP8 is essential in primary myoblasts and contributes to activation of SOD2.
Gordon SJV, Fenker DE, Vest KE, Padilla-Benavides T., Free PMC Article | 06/6/2020 |
| Study in Slc39a8(neo/neo) knockdown mice conclude that deficient ZIP8-mediated divalent cation transport affects zinc-finger (e.g. GATA proteins) and other transcription factors interacting with GATA proteins (e.g. TAL1), predominantly in yolk sac. These data strongly support the phenotype of dysmorphogenesis and anemia seen in Slc39a8(neo/neo) mice in utero. | In utero gene expression in the Slc39a8(neo/neo) knockdown mouse.
Chen J, Gálvez-Peralta M, Zhang X, Deng J, Liu Z, Nebert DW., Free PMC Article | 11/2/2019 |
| Hepatic ZIP8 knockdown leads to selenium deficit, liver pathology, oxidative stress and tumor formation. | Hepatic ZIP8 deficiency is associated with disrupted selenium homeostasis, liver pathology, and tumor formation.
Liu L, Geng X, Cai Y, Copple B, Yoshinaga M, Shen J, Nebert DW, Wang H, Liu Z., Free PMC Article | 08/17/2019 |
| Slc39a8 is expressed in the developing heart and regulates Zn levels. Slc39a8 deletion results in hypertrabeculation and noncompaction. | Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.
Lin W, Li D, Cheng L, Li L, Liu F, Hand NJ, Epstein JA, Rader DJ., Free PMC Article | 07/20/2019 |
| Data suggest that most if not all tissues use ZIP8 and ZIP14A/ZIP14B (alternative splicing products) for Zn(2+) uptake, some tissues under basal conditions and others more so when inflammatory stressors are present (as in endotoxemia); collectively, this might lead to substantial alterations in plasma Zn(2+) levels due to Zn(2+) redistribution not just in liver but across many vital organs. | Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals.
Gálvez-Peralta M, Wang Z, Bao S, Knoell DL, Nebert DW., Free PMC Article | 01/20/2018 |
| ZIP8 reclaims Mn from bile and regulates whole-body Mn homeostasis. | Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity.
Lin W, Vann DR, Doulias PT, Wang T, Landesberg G, Li X, Ricciotti E, Scalia R, He M, Hand NJ, Rader DJ., Free PMC Article | 09/30/2017 |
| Intravitreal holo-transferrin injection decreased Zip 14 protein levels. These data indicate that Zip8 and Zip14 may take up increasing amounts of non-transferrin bound iron in these two mouse models of retinal iron accumulation. | Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels.
Sterling J, Guttha S, Song Y, Song D, Hadziahmetovic M, Dunaief JL., Free PMC Article | 06/24/2017 |
| In the inhibition study, iron and cadmium competitively, and cobalt, nickel and copper non-competitively inhibited the mZIP8-mediated zinc uptake, the inhibition constants being calculated to be 3.37, 55.5, 80.6, 198 and 48.3muM, respectively. | Inhibitory effect of divalent metal cations on zinc uptake via mouse Zrt-/Irt-like protein 8 (ZIP8).
Koike A, Sou J, Ohishi A, Nishida K, Nagasawa K. | 03/18/2017 |
| Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8-MTF1 axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction. | Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis.
Lee M, Won Y, Shin Y, Kim JH, Chun JS. | 10/1/2016 |
| Data, including data from transgenic mice with high Slc39a8 gene copy number, suggest that early signs of cadmium poisoning (via oral exposure to cadmium chloride) are not exacerbated by increased expression of Slc39a8. | Oral cadmium in mice carrying 5 versus 2 copies of the Slc39a8 gene: comparison of uptake, distribution, metal content, and toxicity.
Schneider SN, Liu Z, Wang B, Miller ML, Afton SE, Soleimani M, Nebert DW. | 11/8/2014 |
| We ligated mouse ZIP14A, ZIP14B and ZIP8 cDNA coding regions into the Xenopus-specific vector pXFRM, transcribed these in vitro, and microinjected the capped RNAs into Xenopus oocytes. K(m) and V(max) values for Cd, Zn and Fe uptake were determined. | ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition.
Nebert DW, Gálvez-Peralta M, Hay EB, Li H, Johansson E, Yin C, Wang B, He L, Soleimani M. | 07/6/2013 |
| The knockdown of ZIP8, ZIP14 or DMT1 by siRNA transfection significantly reduced the uptake of Cd(2+) and Mn(2+) from the apical membrane. | Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells.
Fujishiro H, Yano Y, Takada Y, Tanihara M, Himeno S. | 11/3/2012 |
| Observations indicate that ZIP14 and ZIP8 are both broad-scope metal-ion transporters that can mediate the cellular uptake of nutritionally important metals as well as the toxic heavy metal cadmium. | Physiologic implications of metal-ion transport by ZIP14 and ZIP8.
Jenkitkasemwong S, Wang CY, Mackenzie B, Knutson MD., Free PMC Article | 10/27/2012 |
| Results show that ZIP8-mediated zinc transport plays an unappreciated critical role during in utero and neonatal growth, organ morphogenesis, and hematopoiesis. | ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero.
Gálvez-Peralta M, He L, Jorge-Nebert LF, Wang B, Miller ML, Eppert BL, Afton S, Nebert DW., Free PMC Article | 09/22/2012 |