| Treadmill exercise reduces alpha-synuclein spreading via PPARalpha. | Treadmill exercise reduces α-synuclein spreading via PPARα.
Dutta D, Paidi RK, Raha S, Roy A, Chandra S, Pahan K., Free PMC Article | 07/23/2022 |
| p21-activated kinase 4 controls the aggregation of alpha-synuclein by reducing the monomeric and aggregated forms of alpha-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1. | p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1.
Won SY, Park JJ, You ST, Hyeun JA, Kim HK, Jin BK, McLean C, Shin EY, Kim EG., Free PMC Article | 07/9/2022 |
| Accumulation of Prion and Abnormal Prion Protein Induces Hyperphosphorylation of alpha-Synuclein in the Brain Tissues from Prion Diseases and in the Cultured Cells. | Accumulation of Prion and Abnormal Prion Protein Induces Hyperphosphorylation of α-Synuclein in the Brain Tissues from Prion Diseases and in the Cultured Cells.
Chen DD, Gao LP, Wu YZ, Chen J, Hu C, Xiao K, Chen C, Shi Q, Dong XP. | 11/6/2021 |
| Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC. | Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC.
Han JY, Shin C, Choi YP., Free PMC Article | 08/21/2021 |
| Transglutaminase 2 Depletion Attenuates alpha-Synuclein Mediated Toxicity in Mice. | Transglutaminase 2 Depletion Attenuates α-Synuclein Mediated Toxicity in Mice.
Zhang J, Grosso Jasutkar H, Yan R, Woo JM, Lee KW, Im JY, Junn E, Iismaa SE, Mouradian MM., Free PMC Article | 06/26/2021 |
| alpha-Synuclein Promotes Maturation of Immature Juxtaglomerular Neurons in the Mouse Olfactory Bulb. | α-Synuclein Promotes Maturation of Immature Juxtaglomerular Neurons in the Mouse Olfactory Bulb.
Taguchi K, Watanabe Y, Tsujimura A, Tanaka M. | 12/5/2020 |
| Dopaminergic neuron injury in Parkinson's disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ alpha-synuclein pathway. | Dopaminergic neuron injury in Parkinson's disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway.
Zhang LM, Wang MH, Yang HC, Tian T, Sun GF, Ji YF, Hu WT, Liu X, Wang JP, Lu H., Free PMC Article | 10/3/2020 |
| Study suggests alpha-synucleinopathy induction, via retrograde and contralateral projections, within the olfactory system of transgenic animals. | Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson's disease A53T mouse model.
Flores-Cuadrado A, Saiz-Sanchez D, Mohedano-Moriano A, Martinez-Marcos A, Ubeda-Bañon I., Free PMC Article | 04/25/2020 |
| Intracytoplasmic Lewy bodies are primarily composed of the protein alpha-synuclein which increases in substantia nigra of Parkinson's disease. | Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model.
Yeo S, Lim S. | 10/19/2019 |
| This study showed that A53T-alpha-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. | A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.
Henrich MT, Geibl FF, Lee B, Chiu WH, Koprich JB, Brotchie JM, Timmermann L, Decher N, Matschke LA, Oertel WH., Free PMC Article | 06/1/2019 |
| The finding of increased spine pathology in Thy1-E57K is a new pathogenic function of oligomeric a-syn and precedes overt neurodegeneration. Thus, it may constitute a readout for therapeutic approache. | Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice.
Regensburger M, Schreglmann SR, Stoll S, Rockenstein E, Loskarn S, Xiang W, Masliah E, Winner B., Free PMC Article | 03/2/2019 |
| Mulberry fruit extract had inhibitory effects on the up-regulation of both alpha-synuclein and ubiquitin, the major components of lewy bodies, in substantia nigra and striatum in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of early Parkinson's disease . | Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing α-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model.
Gu PS, Moon M, Choi JG, Oh MS. | 01/20/2018 |
| Enhanced aggregation and phosphorylation of alphaSyn causes the loss of dopaminergic neurons leading to the decline of motor coordination. | Sigma-1 receptor knockout increases α-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra.
Hong J, Wang L, Zhang T, Zhang B, Chen L. | 01/13/2018 |
| 2,3,7,8-tetrachlorodibenzo-p-dioxin promoted synphilin-1 degradation in an aryl hydrocarbon receptor-dependent way. | TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain.
González-Barbosa E, Mejía-García A, Bautista E, Gonzalez FJ, Segovia J, Elizondo G., Free PMC Article | 01/6/2018 |
| These results suggest that alpha-syn might participate in mechanisms of vulnerability of selected neuronal populations in AD and that reducing alpha-syn might be a potential approach to protecting these populations from the toxic effects of amyloid beta. | Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.
Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E., Free PMC Article | 07/15/2017 |
| Neurons of A53T-alpha-Syn transgenic mice are more fragile to DNA damages. | DNA damage preceding dopamine neuron degeneration in A53T human α-synuclein transgenic mice.
Wang D, Yu T, Liu Y, Yan J, Guo Y, Jing Y, Yang X, Song Y, Tian Y. | 05/27/2017 |
| This study shows that alpha-synuclein is present in cerebellar glutamatergic terminals. | α-Synuclein expression in the mouse cerebellum is restricted to VGluT1 excitatory terminals and is enriched in unipolar brush cells.
Lee SK, Sillitoe RV, Silva C, Martina M, Sekerkova G., Free PMC Article | 07/30/2016 |
| These results suggest that increased levels of NUB1 play a potential role in degradation of detergent-insoluble alpha-synuclein in vivo, although it is insufficient to degrade abnormal alpha-synuclein in Lewy body disease model mice. | The role of NUB1 in α-synuclein degradation in Lewy body disease model mice.
Tanji K, Miki Y, Maruyama A, Mori F, Mimura J, Itoh K, Kamitani T, Wakabayashi K. | 06/28/2016 |
| SP1 results in a CCK response deficiency that may contribute to the increased meal size and overall hyperphagia in synphillin-1 transgenic mice | CCK Response Deficiency in Synphilin-1 Transgenic Mice.
Smith WW, Smith M, Yang D, Choi PP, Moghadam A, Li T, Moran TH., Free PMC Article | 06/28/2016 |
| TEM analysis of protein:inhibitor assays demonstrated that scyllo-inositol inhibits the aggregation of alpha-synuclein, suggesting the therapeutic potential of the small molecule in PD. | α-Synuclein aggregation, seeding and inhibition by scyllo-inositol.
Ibrahim T, McLaurin J. | 05/28/2016 |
| We exploited atomic force microscopy (AFM) for the selective, nanoscale confinement of alpha-Synuclein on gold to study the early stages of alpha-Synuclein aggregation and the effect of small molecules, like dopamine, on the aggregation process. | Atomic force microscopy based nanoassay: a new method to study α-Synuclein-dopamine bioaffinity interactions.
Corvaglia S, Sanavio B, Hong Enriquez RP, Sorce B, Bosco A, Scaini D, Sabella S, Pompa PP, Scoles G, Casalis L., Free PMC Article | 03/12/2016 |
| an important role of aSyn H50 in the pathogenesis of both sporadic and monogenic Parkinson's disease | Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity.
Xiang W, Menges S, Schlachetzki JC, Meixner H, Hoffmann AC, Schlötzer-Schrehardt U, Becker CM, Winkler J, Klucken J., Free PMC Article | 09/26/2015 |
| Sncaip physically interacts with PPP1 and affects PPP1 sorting to subcellular compartments. | Synphilin-1A is a phosphoprotein phosphatase 1-interacting protein and affects PPP1 sorting to subcellular compartments.
Ferreira-Fernandes E, Esteves SL, Korrodi-Gregório L, Luers G, Afreixo V, Fardilha M, da Cruz e Silva OA. | 09/12/2015 |
| Studies identify a novel function of synphilin-1 in controlling food intake and body weight, and may provide a unique obesity model for future studies of obesity pathogenesis and therapeutics. | A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice.
Li X, Tamashiro KL, Liu Z, Bello NT, Wang X, Aja S, Bi S, Ladenheim EE, Ross CA, Moran TH, Smith WW., Free PMC Article | 01/26/2013 |
| Synphilin-1 can diminish the severity of alpha-synucleinopathy and play a neuroprotective role against A53T alpha-synuclein toxicity in vivo. | Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.
Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA., Free PMC Article | 09/27/2010 |