| Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells. | Agonist-induced extracellular vesicles contribute to the transfer of functional bombesin receptor-subtype 3 to recipient cells.
Wang Z, Wu L, Wang H, Zhang Y, Xiao H., Free PMC Article | 01/29/2022 |
| BRS-3 protein levels were decreased in diabetic rat and in obese and diabetic human fat pieces. | Activation of bombesin receptor Subtype-3 by [D-Tyr(6),β-Ala(11),Phe(13),Nle(14)]bombesin(6-14) increased glucose uptake and lipogenesis in human and rat adipocytes.
Moreno-Villegas Z, Martín-Duce A, Aparicio C, Portal-Núñez S, Sanz R, Mantey SA, Jensen RT, Lorenzo O, Egido J, González N. | 05/11/2019 |
| BRS-3 and EP3 interact to potentiate PGE2 signaling. This potentiating effect is receptor specific, and it occurs only when BRS-3 is paired to EP3. | Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.
Zhang Y, Liu Y, Wu L, Fan C, Wang Z, Zhang X, Alachkar A, Liang X, Civelli O., Free PMC Article | 01/19/2019 |
| These results suggest that human BRS-3, similar to GRPR/NMBR, is frequently ectopically-expressed by lung-cancer cells in which, it is functional, affecting cell signaling/growth. | A possible new target in lung-cancer cells: The orphan receptor, bombesin receptor subtype-3.
Moreno P, Mantey SA, Lee SH, Ramos-Álvarez I, Moody TW, Jensen RT., Free PMC Article | 12/29/2018 |
| mammalian homologue of CCHa2-R, Bombesin receptor subtype-3 (Brs3), is an orphan receptor that is expressed in the islet beta-cells | The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster.
Sano H, Nakamura A, Texada MJ, Truman JW, Ishimoto H, Kamikouchi A, Nibu Y, Kume K, Ida T, Kojima M., Free PMC Article | 04/9/2016 |
| High BRS3 expression is associated with liver metastases of pancreas neuroendocrine tumors. | Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors.
Sherman SK, Maxwell JE, Carr JC, Wang D, Bellizzi AM, Sue O'Dorisio M, O'Dorisio TM, Howe JR., Free PMC Article | 02/14/2015 |
| The role of the human BRS-3 receptor in glucose homeostasis. | Human BRS-3 receptor: functions/role in cell signaling pathways and glucose metabolism in obese or diabetic myocytes.
Ramos-Álvarez I, Moreno-Villegas Z, Martín-Duce A, Sanz R, Aparicio C, Portal-Núñez S, Mantey SA, Jensen RT, González N. | 09/6/2014 |
| Data show that gastrin-releasing peptide receptor/bombesin receptor subtype-3 positive cells and protein expression in tumors decreased by treatment with RC-3095 or gemcitabine alone or greater in combination. | RC-3095, a gastrin-releasing peptide receptor antagonist, synergizes with gemcitabine to inhibit the growth of human pancreatic cancer CFPAC-1 in vitro and in vivo.
Hong SK, Yang SY, Yin SH, Yang KX. | 08/16/2014 |
| BRS-3 plays an important role in glucose metabolism. | Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes.
Ramos-Álvarez I, Martín-Duce A, Moreno-Villegas Z, Sanz R, Aparicio C, Portal-Núñez S, Mantey SA, Jensen RT, González N. | 09/28/2013 |
| BRS-3 agonist-dependent signaling mediates CREB phosphorylation and transactivation through protein kinase (PK)A, (PK)C, and mitogen-activated protein/extracellular regulated kinase kinase (MEK)-1 pathways. | A selective human bombesin receptor subtype-3 peptide agonist mediates CREB phosphorylation and transactivation.
Qin X, Qu X, Coy D, Weber HC. | 01/26/2013 |
| These results identify a potential role for BRS-3 in islet physiology, with agonism directly promoting glucose-stimulated insulin secretion | Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.
Feng Y, Guan XM, Li J, Metzger JM, Zhu Y, Juhl K, Zhang BB, Thornberry NA, Reitman ML, Zhou YP. | 12/10/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| The secretion of TGF-beta1 increased and the synthesis of PGE2 decreased from BRS-3-activated BEC, which were correlated with the proliferation and collagen synthesis of HLF. | BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts.
Wang Y, Zhang M, Tan Y, Xiang Y, Liu H, Qu F, Qin L, Qin X. | 01/21/2010 |
| Study found that the BRS-3 agonist stimulated adhesion of NCI-N417 cells in laminin-coated culture wells suggesting that BRS-3 may be involved in invasion and metastasis of certain cancer cells | Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells.
Hou X, Wei L, Harada A, Tatamoto K. | 01/21/2010 |
| Data suggest that activator protein 2alpha and peroxisome-proliferator-activated receptor alpha may be especially involved in the ozone-inducible up-regulation mechanism of bombesin receptor subtype 3 expression. | PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells.
Tan YR, Qin XQ, Xiang Y, Yang T, Qu F, Wang Y, Liu HJ, Weber HC., Free PMC Article | 01/21/2010 |
| results indicate that the sequence variation in the E3 loop is responsible for the species difference between rat and human BRS-3, and multiple residues in the E3 loop are involved in interactions with the agonist dY-bombesin | Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).
Liu J, Lao ZJ, Zhang J, Schaeffer MT, Jiang MM, Guan XM, Van der Ploeg LH, Fong TM. | 01/21/2010 |