| DNA hypomethylation of Syk induces oxidative stress and apoptosis via the PKCbeta/P66shc signaling pathway in diabetic kidney disease. | DNA hypomethylation of Syk induces oxidative stress and apoptosis via the PKCβ/P66shc signaling pathway in diabetic kidney disease.
Zhang R, Qin C, Zhang J, HonghongRen, Wang Y, Wu Y, Zhao L, Wang J, Zhang J, Liu F. | 04/17/2024 |
| Mast cells are upregulated in hidradenitis suppurativa tissue, associated with epithelialized tunnels and normalized by spleen tyrosine kinase antagonism. | Mast cells are upregulated in hidradenitis suppurativa tissue, associated with epithelialized tunnels and normalized by spleen tyrosine kinase antagonism.
Flora A, Jepsen R, Kozera EK, Woods JA, Cains GD, Radzieta M, Jensen SO, Malone M, Frew JW. | 02/7/2024 |
| Spleen tyrosine kinase facilitates the progression of papillary thyroid cancer regulated by the hsa_circ_0006417/miR-377-3p axis. | Spleen tyrosine kinase facilitates the progression of papillary thyroid cancer regulated by the hsa_circ_0006417/miR-377-3p axis.
Tan G, Zheng S, Zhou B, Mo Z, Zhang Q, Zhang D, Li A, Liu X. | 01/3/2024 |
| Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU. | Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
Chen B, Song Y, Yang X, Yang J, Hao F. | 10/26/2023 |
| Expanding Our Knowledge of Molecular Pathogenesis in Histiocytoses: Solitary Soft Tissue Histiocytomas in Children With a Novel CLTC::SYK Fusion. | Expanding Our Knowledge of Molecular Pathogenesis in Histiocytoses: Solitary Soft Tissue Histiocytomas in Children With a Novel CLTC::SYK Fusion.
Crowley HM, Georgantzoglou N, Tse JY, Williams EA, Mata DA, Martin SS, Guitart J, Bridge JA, Linos K. | 09/21/2023 |
| Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets. | Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets.
Zhang P, Solari FA, Heemskerk JWM, Kuijpers MJE, Sickmann A, Walter U, Jurk K., Free PMC Article | 05/19/2023 |
| Epigenetic upregulation of spleen tyrosine kinase in cancer cells through p53-dependent downregulation of DNA methyltransferase. | Epigenetic upregulation of spleen tyrosine kinase in cancer cells through p53-dependent downregulation of DNA methyltransferase.
Huang DY, Lu ST, Chen YS, Cheng CY, Lin WW. | 03/31/2023 |
| Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19. | Spleen tyrosine kinase inhibition restores myeloid homeostasis in COVID-19.
Wigerblad G, Warner SA, Ramos-Benitez MJ, Kardava L, Tian X, Miao R, Reger R, Chakraborty M, Wong S, Kanthi Y, Suffredini AF, Dell'Orso S, Brooks S, King C, Shlobin O, Nathan SD, Cohen J, Moir S, Childs RW, Kaplan MJ, Chertow DS, Strich JR., Free PMC Article | 01/14/2023 |
| Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. | Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Prendecki M, Gulati K, Pisacano N, Pinheiro D, Bhatt T, Mawhin MA, Toulza F, Masuda ES, Cowburn A, Lodge KM, Tam FWK, Roufosse C, Pusey CD, McAdoo SP., Free PMC Article | 12/31/2022 |
| The ubiquitous role of spleen tyrosine kinase (Syk) in gut diseases: From mucosal immunity to targeted therapy. | The ubiquitous role of spleen tyrosine kinase (Syk) in gut diseases: From mucosal immunity to targeted therapy.
Gong W, Liu P, Zheng T, Wu X, Zhao Y, Ren J. | 10/15/2022 |
| Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry. | Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry.
Cheung HYF, Moran LA, Sickmann A, Heemskerk JWM, Garcia Á, Watson SP. | 10/15/2022 |
| A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas. | A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas.
Munshi M, Liu X, Kofides A, Tsakmaklis N, Guerrera ML, Hunter ZR, Palomba ML, Argyropoulos KV, Patterson CJ, Canning AG, Meid K, Gustine J, Branagan AR, Flynn CA, Sarosiek S, Castillo JJ, Wang J, Buhrlage SJ, Gray NS, Munshi NC, Anderson KC, Treon SP, Yang G., Free PMC Article | 06/18/2022 |
| SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies. | SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies.
Leveille E, Chan LN, Mirza AS, Kume K, Müschen M. | 05/7/2022 |
| SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis. | SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis.
Luci C, Vieira E, Bourinet M, Rousseau D, Bonnafous S, Patouraux S, Lefevre L, Larbret F, Prod'homme V, Iannelli A, Tran A, Anty R, Bailly-Maitre B, Deckert M, Gual P., Free PMC Article | 04/9/2022 |
| Regulatory interplay between Vav1, Syk and beta-catenin occurs in lung cancer cells. | Regulatory interplay between Vav1, Syk and β-catenin occurs in lung cancer cells.
Boudria R, Laurienté V, Oudar A, Harouna-Rachidi S, Dondi E, Le Roy C, Gardano L, Varin-Blank N, Guittat L. | 04/9/2022 |
| STING-Mediated Interferon Induction by Herpes Simplex Virus 1 Requires the Protein Tyrosine Kinase Syk. | STING-Mediated Interferon Induction by Herpes Simplex Virus 1 Requires the Protein Tyrosine Kinase Syk.
Wang C, Sharma N, Veleeparambil M, Kessler PM, Willard B, Sen GC., Free PMC Article | 02/26/2022 |
| Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases. | Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Hobbs HT, Shah NH, Badroos JM, Gee CL, Marqusee S, Kuriyan J., Free PMC Article | 02/12/2022 |
| Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear. | Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear.
Perrella G, Montague SJ, Brown HC, Garcia Quintanilla L, Slater A, Stegner D, Thomas M, Heemskerk JWM, Watson SP., Free PMC Article | 02/5/2022 |
| miR-96-5p is the tumor suppressor in osteosarcoma via targeting SYK. | miR-96-5p is the tumor suppressor in osteosarcoma via targeting SYK.
Wang T, Xu Y, Liu X, Zeng Y, Liu L. | 11/22/2021 |
| Comprehensive analysis of Syk gene methylation in colorectal cancer. | Comprehensive analysis of Syk gene methylation in colorectal cancer.
Bu F, Zhu X, Liu S, Lin K, Zhu J, Huang J., Free PMC Article | 10/23/2021 |
| Complement receptor 3 mediates both sinking phagocytosis and phagocytic cup formation via distinct mechanisms. | Complement receptor 3 mediates both sinking phagocytosis and phagocytic cup formation via distinct mechanisms.
Walbaum S, Ambrosy B, Schütz P, Bachg AC, Horsthemke M, Leusen JHW, Mócsai A, Hanley PJ., Free PMC Article | 08/21/2021 |
| TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia. | TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia.
Zhang YR, Yu Z, Xiong WJ, Liu XX, Liu HM, Cui R, Wang Q, Chen WM, Qiu LG, Yi SH., Free PMC Article | 07/10/2021 |
| Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer. | Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Sadras T, Martin M, Kume K, Robinson ME, Saravanakumar S, Lenz G, Chen Z, Song JY, Siddiqi T, Oksa L, Knapp AM, Cutler J, Cosgun KN, Klemm L, Ecker V, Winchester J, Ghergus D, Soulas-Sprauel P, Kiefer F, Heisterkamp N, Pandey A, Ngo V, Wang L, Jumaa H, Buchner M, Ruland J, Chan WC, Meffre E, Martin T, Müschen M., Free PMC Article | 06/19/2021 |
| IRF4 modulates the response to BCR activation in chronic lymphocytic leukemia regulating IKAROS and SYK. | IRF4 modulates the response to BCR activation in chronic lymphocytic leukemia regulating IKAROS and SYK.
Maffei R, Fiorcari S, Benatti S, Atene CG, Martinelli S, Zucchini P, Potenza L, Luppi M, Marasca R. | 06/19/2021 |
| Spleen tyrosine kinase regulates crosstalk of hypoxia-inducible factor-1alpha and nuclear factor (erythroid-derived2)-like 2 for B cell survival. | Spleen tyrosine kinase regulates crosstalk of hypoxia-inducible factor-1α and nuclear factor (erythroid-derived2)-like 2 for B cell survival.
Jang JW, Park S, Moon EY. | 06/12/2021 |