| PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. | PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing.
Cikes D, Elsayad K, Sezgin E, Koitai E, Torma F, Orthofer M, Yarwood R, Heinz LX, Sedlyarov V, Miranda ND, Taylor A, Grapentine S, Al-Murshedi F, Abot A, Weidinger A, Kutchukian C, Sanchez C, Cronin SJF, Novatchkova M, Kavirayani A, Schuetz T, Haubner B, Haas L, Hagelkruys A, Jackowski S, Kozlov AV, Jacquemond V, Knauf C, Superti-Furga G, Rullman E, Gustafsson T, McDermot J, Lowe M, Radak Z, Chamberlain JS, Bakovic M, Banka S, Penninger JM. | 03/30/2023 |
| p75NTR enhances cognitive dysfunction in a mouse Alzheimer's disease model by inhibiting microRNA-210-3p-mediated PCYT2 through activation of NF-kappaB. | p75NTR enhances cognitive dysfunction in a mouse Alzheimer's disease model by inhibiting microRNA-210-3p-mediated PCYT2 through activation of NF-κB.
Wei Z, Yang C, Feng K, Guo S, Huang Z, Wang Y, Jian C. | 03/8/2023 |
| Pcyt2 deficiency causes age-dependant development of nonalcoholic steatohepatitis and insulin resistance that could be attenuated with phosphoethanolamine. | Pcyt2 deficiency causes age-dependant development of nonalcoholic steatohepatitis and insulin resistance that could be attenuated with phosphoethanolamine.
Grapentine S, Singh RK, Basu P, Sivanesan S, Mattos G, Oresajo O, Cheema J, Demeke W, Dolinsky VW, Bakovic M., Free PMC Article | 03/12/2022 |
| we conclude that NF-Y and YY1 are important for the basal transcription of Pcyt2 and that NF-Y is involved in the inhibitory effects of 25-HC on Pcyt2 transcription. | Transcriptional suppression of CTP:phosphoethanolamine cytidylyltransferase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang 1.
Ando H, Aoyama C, Horibata Y, Satou M, Mitsuhashi S, Itoh M, Hosaka K, Sugimoto H. | 01/30/2016 |
| The data identify Pcyt2 and membrane Phosphatidylethanolamine biogenesis as important determinants of gender-specific differences in cardiac lipids and heart function. | Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice.
Basu P, Alibhai FJ, Tsimakouridze EV, Singh RK, Paglialunga S, Holloway GP, Martino TA, Bakovic M., Free PMC Article | 10/3/2015 |
| The naturally occurring splice variant Pcyt2gamma has a function to restrain the enzyme activity through the formation of unproductive enzyme complexes. | A novel murine CTP:phosphoethanolamine cytidylyltransferase splice variant is a post-translational repressor and an indicator that both cytidylyltransferase domains are required for activity.
Pavlovic Z, Singh RK, Bakovic M. | 07/5/2014 |
| differences in phosphorylation between Pcyt2 isoforms | Isoform-specific and protein kinase C-mediated regulation of CTP:phosphoethanolamine cytidylyltransferase phosphorylation.
Pavlovic Z, Zhu L, Pereira L, Singh RK, Cornell RB, Bakovic M., Free PMC Article | 05/24/2014 |
| hypertriglyceridemia that accompanies Pcyt2 deficiency is the result of multiple metabolic adaptations | Mechanism of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase-deficient mice.
Singh RK, Fullerton MD, Vine D, Bakovic M., Free PMC Article | 12/8/2012 |
| data unambiguously establish that the TAG accumulation present in Pcyt2-deficient hepatocytes is a direct consequence of Pcyt2 gene deficiency and reduced functioning of the de novo Kennedy pathway | Complementation of the metabolic defect in CTP:phosphoethanolamine cytidylyltransferase (Pcyt2)-deficient primary hepatocytes.
Fullerton MD, Bakovic M. | 01/1/2011 |
| PE phospholipids, Pcyt2 deficiency generates compensatory changes in triglyceride and energy substrate metabolism, resulting in a progressive development of liver steatosis, hypertriglyceridemia, obesity, and insulin resistance | The development of a metabolic disease phenotype in CTP:phosphoethanolamine cytidylyltransferase-deficient mice.
Fullerton MD, Hakimuddin F, Bonen A, Bakovic M., Free PMC Article | 01/21/2010 |
| study of the importance of the CDP-ethanolamine pathway in controlling the molecular species composition of phosphatidylethanolamine via Phosphoethanolamine cytidylyltransferase knock-out | Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.
Leonardi R, Frank MW, Jackson PD, Rock CO, Jackowski S., Free PMC Article | 01/21/2010 |
| Regulation of the mouse CTP: phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis | Regulation of the mouse CTP: phosphoethanolamine cytidylyltransferase gene Pcyt2 during myogenesis.
Zhu L, Michel V, Bakovic M. | 01/21/2010 |
| alternative splicing of the mPcyt2 transcript is ubiquitous but could also be regulated in a tissue-specific manner, producing a variable ratio of mPcyt2alpha/mPcyt2beta mRNAs | Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties.
Tie A, Bakovic M. | 01/21/2010 |
| single Pcyt2 allele in heterozygotes can maintain phospholipid homeostasis | Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2).
Fullerton MD, Hakimuddin F, Bakovic M., Free PMC Article | 01/21/2010 |